Ruthenium complexes with diazadienes. 4. Arene diazadiene ruthenium(II) complexes [(.eta.6-arene)(RN:CR':CR':NR)Ru(L)]n+ (n = 1, L = Cl, I, alkyl; n = 2, L = MeCN, .eta.2-C2H4) and arene diazadiene ruthenium(0)

Dieck, Heindirk tom; Kollvitz, Wolfgang; Kleinwaechter, I. +

doi:10.1021/om00138a026

Cited by 23 publications

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“…This is indicative of the involvement of the ligand p* orbital in the reduction. 14 The redox potentials of the chloride-dissociated complexes [(Z 6 -mes)Ru(L)] (E 2 ) show almost the same trend as E 1 .…”

Section: Electrochemical Studiesmentioning

confidence: 87%

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Synthesis and photochromic studies of η6-mesitylene ruthenium(ii) complexes bearing N-heterocyclic carbene ligands with the dithienylethene moiety

2011

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Section: Electrochemical Studiesmentioning

confidence: 87%

“…13 The relatively intense band at 265 nm is assigned as IL(NHC-py) transition, with some mixing of a dp(Ru)p*(mesitylene) MLCT character. 14 Compared to its counterpart without the dithienylethene moiety, the electronic absorption spectrum of complex 8 shows much higher extinction coefficient at around 240 nm (Fig. 2).…”

Section: Electronic Absorption Studiesmentioning

confidence: 93%

Synthesis and photochromic studies of η6-mesitylene ruthenium(ii) complexes bearing N-heterocyclic carbene ligands with the dithienylethene moiety

2011

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“…α-Diimines (also called 1,4-diaza-1,3-dienes) are among the most robust and versatile ligands available in synthetic coordination chemistry and possess finely tunable steric and electronic properties . Although some ruthenium η 6 -arene complexes with α-diimine ligands, i.e., (R)NC(R′)C(R′)N(R) (R = alkyl or aryl; R′ = H and Me) were reported, they did not undergo biological evaluation …”

Section: Introductionmentioning

confidence: 99%

α-Diimines as Versatile, Derivatizable Ligands in Ruthenium(II) p-Cymene Anticancer Complexes

et al. 2018

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α-Diimines are among the most robust and versatile ligands available in synthetic coordination chemistry, possessing finely tunable steric and electronic properties. A series of novel cationic ruthenium(II) p-cymene complexes bearing simple α-diimine ligands, [(η- p-cymene)RuCl{κ N-(HCNR)}]NO (R = Cy, [1]NO; R = 4-CHOH, [2]NO; R = 4-CHOH, [3]NO), were prepared in near-quantitative yields as their nitrate salts. [2]NO displays high water solubility. The potential of the α-diimine ligand in [3]NO as a carrier of bioactive molecules was investigated via esterification reactions with the hydroxyl groups. Thus, the double-functionalized derivatives [(η- p-cymene)RuCl{κ N-(HCN(4-CHOCO-R))}]NO (R = aspirinate, [5]NO; valproate, [6]NO) and also [4]Cl (R = Me) were obtained in good-to-high yields. UV-vis and multinuclear NMR spectroscopy and cyclic voltammetric studies in aqueous solution revealed only minor ruthenium chloride hydrolytic cleavage, biologically accessible reduction potentials, and pH-dependent behavior of [3]NO. Density functional theory analysis was performed in order to compare the Ru-Cl bond strength in [1] with the analogous ethylenediamine complex, showing that the higher stability observed in the former is related to the electron-withdrawing properties of the α-diimine ligand. In vitro cytotoxicity studies were performed against tumorigenic (A2780 and A2780cisR) and nontumorigenic (HEK-293) cell lines, with the complexes bearing simple α-diimine ligands ranging from inactive to IC values in the low micromolar range. The complexes functionalized with bioactive components, i.e., [5]NO and [6]NO, exhibited a marked increase in the cytotoxicity with respect to the precursor [3]NO.

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“…Da sich aus dem dimeren Cycloheptatrien-dichlororuthenium (4) [5] mit l,4-Diaza-l,3-dienen (DAD) (1) keine einheitliche saubere Verbindung [(cyclo-C 7 H 8 )(DAD)RuCl]Cl erhalten ließ, wie dies analog für entsprechende Benzolkomplexe gelingt [4], wähl-ten wir für das Zielmolekül einen reduktiven Weg direkt aus 4. Mit weiteren Olefinliganden ist ein solcher Weg (Isopropylgrignard-Methode) erfolgreich beschritten worden [6], Eine Suspension von 4 wird mit überschüssigem Lithium und einer äquimolaren Menge 1 (R = i- …”

Section: Synthese Von Cycloheptatrien-diazadienruthenium(o) (5)unclassified

Rutheniumkomplexe mit Diazadienen, VI [1] η⁶-Cycloheptatrien-und η⁴ -Norbornadien-diazadien-ruthenium(0)-Komplexe / Ruthenium Complexes with Diazadienes, VI [1] η⁶-Cycloheptatriene-and η⁴-Norbornadiene-diazadiene-ruthenium(0) Complexes

Dieck

Kleinwächter

1987

Zeitschrift Für Naturforschung B

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Abstract Reduction of [(cyclo-C7H8)RuCl2]2 in the presence of a diazadiene RN=CH−CH=NR (DAD; R = i-C3H7) gives red, airsensitive, sublimable (η6-C7H8)Ru(DAD) (5). A rigid structure on the basis of the 1H NMR spectrum is excluded. On the other hand pentacoordinate complexes [η4-nor-C7H8)Ru(DAD)P(C6H5)3] (8) or [(η4-nor-C7H8)Ru(DAD)CO] (9) have rigid, Cs-symmetric, square-pyramidal structures. They are obtained by chemical or irreversible electro-chemical reduction of [(η4-nor-C7H8)Ru(DAD)Cl2] to [η4-nor-C7H8)Ru(DAD)(solv)] (7) (solv = tetrahydrofuran or acetonitrile) and addition of phosphine or carbon monoxide. 7, in non-coor-dinating solvents, is a stereospecific catalyst for the 1-alkene → trans-2,... -alkene isomerization.

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Ruthenium complexes with diazadienes. 4. Arene diazadiene ruthenium(II) complexes [(.eta.6-arene)(RN:CR':CR':NR)Ru(L)]n+ (n = 1, L = Cl, I, alkyl; n = 2, L = MeCN, .eta.2-C2H4) and arene diazadiene ruthenium(0)

Cited by 23 publications

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Synthesis and photochromic studies of η6-mesitylene ruthenium(ii) complexes bearing N-heterocyclic carbene ligands with the dithienylethene moiety

Synthesis and photochromic studies of η6-mesitylene ruthenium(ii) complexes bearing N-heterocyclic carbene ligands with the dithienylethene moiety

α-Diimines as Versatile, Derivatizable Ligands in Ruthenium(II) p-Cymene Anticancer Complexes

Rutheniumkomplexe mit Diazadienen, VI [1] η⁶-Cycloheptatrien-und η⁴ -Norbornadien-diazadien-ruthenium(0)-Komplexe / Ruthenium Complexes with Diazadienes, VI [1] η⁶-Cycloheptatriene-and η⁴-Norbornadiene-diazadiene-ruthenium(0) Complexes

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Ruthenium complexes with diazadienes. 4. Arene diazadiene ruthenium(II) complexes [(.eta.6-arene)(RN:CR':CR':NR)Ru(L)]n+ (n = 1, L = Cl, I, alkyl; n = 2, L = MeCN, .eta.2-C2H4) and arene diazadiene ruthenium(0)

Cited by 23 publications

References 0 publications

Synthesis and photochromic studies of η6-mesitylene ruthenium(ii) complexes bearing N-heterocyclic carbene ligands with the dithienylethene moiety

Synthesis and photochromic studies of η6-mesitylene ruthenium(ii) complexes bearing N-heterocyclic carbene ligands with the dithienylethene moiety

α-Diimines as Versatile, Derivatizable Ligands in Ruthenium(II) p-Cymene Anticancer Complexes

Rutheniumkomplexe mit Diazadienen, VI [1] η6-Cycloheptatrien-und η4 -Norbornadien-diazadien-ruthenium(0)-Komplexe / Ruthenium Complexes with Diazadienes, VI [1] η6-Cycloheptatriene-and η4-Norbornadiene-diazadiene-ruthenium(0) Complexes

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Rutheniumkomplexe mit Diazadienen, VI [1] η⁶-Cycloheptatrien-und η⁴ -Norbornadien-diazadien-ruthenium(0)-Komplexe / Ruthenium Complexes with Diazadienes, VI [1] η⁶-Cycloheptatriene-and η⁴-Norbornadiene-diazadiene-ruthenium(0) Complexes