Ruthenium-97 Labeled Compounds — a New Class of Radiopharmaceuticals

Measurement of yield of residues produced in 12C+natY reaction and subsequent separation of 97Ru from Y target using cation exchange resin

“…The rich chemical property of ruthenium has been exploited in medical science. Previously 103 Ru (39.25 d) was used in labelling ligands as it is obtained easily by neutron activation of naturally 97 Ru may serve as a very suitable radionuclide among other Ru radionuclides for delayed studies of diagnosis as well as therapy by attaching it to a suitable carrier or ligand [1,2]. It is even possible to use 97 Ru as a tracer to measure the backside wear rate on tibial inserts [3,4].…”

“…In order to separate NCA Ru from the target matrix, various chemical separation methodologies, namely distillation, solvent extraction, ion-exchange method, precipitation, liquid-liquid extraction (LLX), solid liquid extraction (SLX), etc., have been developed so far [1,5,6,[8][9][10][11][12][13][14][15][16] Comar and Crouzel [9] separated NCA 97 Ru by solvent extraction technique using CCl 4 from 95 Tc and bulk Mo. Purity of 97 Ru achieved was more than 99.9%.…”

Separation of 97Ru from niobium target using PEG based aqueous biphasic systems

“…Till date various production routs of 97 Ru were reported in literature usually by neutron activation, proton and alpha particle activation. Generally, NCA 97 Ru was produced by light charge particle activation of nat Rh, nat Ag, 99 Tc, 95 Mo, 94 Mo, nat Mo by nat Rh(p, 2p5n) 97 Ru [15,16], nat Ag(p, 2p5n) 97 Ru [17,18], 99 Tc(p, 3n) 97 Ru [19,20], 95 Mo(a, 2n) 97 Ru [21], 94 Mo(a, n) 97 Ru [22], nat Mo( 4 He, xn) 97 Ru [23][24][25], nat Mo( 3 He, xn) 97 Ru [22,23] respectively. Recently, Maiti and Lahiri [26] reported the production of 97 Ru by heavy ion activation on nat Nb by nat Nb( 7 Li, 3n) 97 Ru and on nat Y by 12 C-induced reaction [27].…”

“…In this process, ruthenium was separated from corresponding targets based on distillation of 97 RuO 4 in concentrated HNO 3 or H 2 SO 4 medium at 90°C. Total separation time for this process was 6-7 h [15,16,19]. Comar and Crouzel [22] employed simple and faster technique like solvent extraction compared to distillation process for the separation of NCA Ru and co-product Tc from Mo target.…”

Stoichiometric complexes tin‐methylenediphosphonate: Composition, biodistribution and elements of structure

“…There is, however, evidence that tin compounds have effects on the chemistry and metabolic fate of Tc-labelled agents, much more important than those of a simple reductant and its oxidation product (7) (8). Even the existence of mixed metal complexes (Tc-Sn) is still controversial ( 9 ) ( 1 0 ) ( 1 1 ) .…”