Abstract:ObjectiveLipid metabolic disorders pose a serious threat to human health, and currently no good treatments exist. In earlier studies by the authors, HepG2 cells with diacylglycerol kinase theta (DGKθ) knockout were found to cause significant lipid accumulation, suggesting that DGKθ may be a potential target for treating lipid metabolic disorders.MethodsA high‐throughput screening of natural products targeting the potential signaling pathway of lipid metabolism was carried out in the DGKθ‐T2A‐luciferase knock‐i… Show more
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