Russian study of morphological prognostic factors characterization in BRAF-mutant cutaneous melanoma

Aksenenko, M. B.; Кириченко, А. К.; Рукша, Т. Г.

doi:10.1016/j.prp.2015.03.005

Cited by 13 publications

(10 citation statements)

References 43 publications

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“…In our study, the frequency of BRAF mutation falls within this range. Over 90% of the Previous studies showed the different value of BRAF mutational status in association with clinicopathological characteristics and PFS of melanoma (27)(28)(29)(30)(31)(32)(33). Our study did not find any association between the BRAF mutational status and PFS of melanoma.…”

Section: Discussioncontrasting

confidence: 66%

“…The associations of BRAF V600 mutational status and Breslow thickness, patient gender, Breslow thickness and peritumoral lymphocytes infiltration was revealed, supporting our previous evidence ( 14 ). Previous studies showed the different value of BRAF mutational status in association with clinicopathological characteristics and PFS of melanoma ( 27 – 33 ). Our study did not find any association between the BRAF mutational status and PFS of melanoma.…”

Section: Discussionmentioning

confidence: 99%

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Effects of BRAF V600E and NRAS mutational status on the progression‑free survival and clinicopathological characteristics of patients with melanoma

et al. 2022

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Hotspot mutations of the BRAF and NRAS genes are the most common genetic alterations in invasive cutaneous melanoma; however, the prognostic significance of BRAF and NRAS co-mutations remains controversial. The present study aimed to determine the association between NRAS and BRAF mutation status and the clinicopathological characteristics of patients with stage IA-IIC melanoma. A total of 118 patients who underwent surgical treatment for stage IA-IIC melanoma at the Riga East University Hospital between 2012 and 2018 were retrospectively enrolled in the present study. BRAF and NRAS mutation status was assessed by digital droplet PCR using the BRAFV600, NRAS Q61 and NRAS G12/G13 Screening Assays. The association between mutation status and clinicopathological features and progression-free survival (PFS) was then analyzed. The BRAF V600 mutation was detected in 67 out of 118 patients (56.8%). The PFS did not differ between patients with BRAF wild-type and BRAF-mutant melanoma. NRAS mutations were detected in 35 out of 118 patients (29.6%). The NRAS mutational status was associated with Breslow thickness (P=0.035), tumor type (P=0.020; χ 2 =0.20), mitotic rate (P=0.025) and lymphovascular invasion (P=0.02; χ 2 =0.20). Patients with NRAS-mutant melanoma had significantly worse PFS compared with NRAS wild-type melanoma (HR=12.30; 95% CI=5.78-26.21, P<0.0001). Furthermore, BRAF and NRAS co-mutant melanoma was associated with a significantly worse PFS compared with BRAF-mutant melanoma (HR=6.30; 95% CI=3.10-12.70, P<0.0001). In conclusion, NRAS-mutant and NRAS/BRAF co-mutant stage IA-IIC melanoma was associated with worse PFS compared with NRAS wild-type and BRAF-mutant melanoma. The assessment of NRAS mutation status in melanoma in routine clinical practice may be beneficial for the risk stratification of disease progression for primary non-metastatic malignant melanoma.

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Section: Discussioncontrasting

confidence: 66%

Section: Discussionmentioning

confidence: 99%

Effects of BRAF V600E and NRAS mutational status on the progression‑free survival and clinicopathological characteristics of patients with melanoma

et al. 2022

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“…Our study showed that TIL was upregulated in BRAF mutant melanoma compared to BRAF wild-type. However, some recent studies did not found associations between TIL and BRAF mutational status (35,38,39).…”

Section: Discussionmentioning

confidence: 99%

Addressing the importance of melanoma tumor‑infiltrating lymphocytes in disease progression and clinicopathological characteristics

et al. 2021

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Tumor-infiltrating lymphocytes (TILs) in primary cutaneous melanoma are considered to represent the host's antitumor immunological response; however, whether there are associations between TIL grade and histopathological characteristics and disease survival remains controversial. BRAF mutational status has been established as a routine screening method in advanced malignant melanoma, and worse prognosis rates have been demonstrated in patients harboring BRAF mutations. However, the general impact of BRAF mutational status on survival and histopathological characteristics is still debated. The aim of the present study was to compare the value of the assessment of TIL grade in stages I-II nodular and superficial spreading melanoma and BRAF mutational status, and its influence on clinicopathological characteristics. Altogether, 85 patients at stage IA-IIC who underwent melanoma surgical treatment at the Riga East University Hospital between 2012 and 2017 were retrospectively enrolled in the study. The histopathological characteristics were assessed according to the current World Health Organization and The American Joint Committee on Cancer 8th edition guidelines. The current study showed that patients with melanoma with high TIL grade had significantly better progression-free survival than patients with low TIL grade (hazard ratio, 4.9; 95% CI, 2.3-11.2; P<0.0001). BRAF mutations were observed in 52 patients (61.2%). BRAF mutational status in melanoma was associated with Clark invasion level (P= 0.045), patient age (P=0.02) and TIL (P=0.04). The assessment of TIL grade in stage I-II melanoma demonstrated prognostic significance value and may help improve risk assessment in the future.

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“…Previous studies have shown that the BRAF V600E mutation is associated with the superficial spreading melanoma subtype, solar elastosis, younger patients, and melanoma localization on the extremities and back. In contrast, BRAF V600K mutations are correlated with skin sites with high CSD, such as the head and neck, and with older patients [14- 19,[35][36][37][38][39][40].…”

Section: Assessment Of Braf Gene Mutation For Stratifying the Risk Of...mentioning

confidence: 99%

The Value of Histopathological Characteristics and BRAF and NRAS Mutations for the Diagnosis, Risk Stratification, and Prognosis of Malignant Invasive Melanoma

Zablocka¹,

Isajevs²

2023

Melanoma - Standard of Care, Challenges, and Updates in Clinical Research

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In recent years, the direction of personalized medicine, which is based on a disease-specific targeting therapy, as well as the early diagnosis of tumors and the identification of high-risk individuals, is rapidly developing in the world. Invasive melanoma is a tumor with high impact for its rapidly growing incidence, high mortality, increased complexity, and high care costs in advanced stages. Recent studies demonstrated the significant value of both conventional histopathological characteristics and genetic alterations in melanoma. This review focuses on the value of conventional histopathological characteristics including histological tumor subtype, Clark level, Breslow thickness, solar elastosis, ulceration, regression, lymphovascular invasion, mitotic counts, peritumoral lymphocyte infiltration, clinical characteristics such as age, gender, length of follow-up after surgery, recurrence, or metastasis, and progression-free survival, and tumor BRAF and NRAS mutations.

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Russian study of morphological prognostic factors characterization in BRAF-mutant cutaneous melanoma

Cited by 13 publications

References 43 publications

Effects of BRAF V600E and NRAS mutational status on the progression‑free survival and clinicopathological characteristics of patients with melanoma

Effects of BRAF V600E and NRAS mutational status on the progression‑free survival and clinicopathological characteristics of patients with melanoma

Addressing the importance of melanoma tumor‑infiltrating lymphocytes in disease progression and clinicopathological characteristics

The Value of Histopathological Characteristics and BRAF and NRAS Mutations for the Diagnosis, Risk Stratification, and Prognosis of Malignant Invasive Melanoma

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