Russell body duodenitis with immunoglobulin kappa light chain restriction

Munday, William R.; Kapur, Lucy Harn; Xu, Mina L; Zhang, Xuchen

doi:10.4253/wjge.v7.i1.73

Cited by 10 publications

(4 citation statements)

References 9 publications

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“…Chen et al [20] 2013 1 59 F Duodenum Yes Polyclonal Diabetes, Hypertension COPD NS 5 zhang et al [9] 2014 1 76 M Duodenum Yes Monoclonal (λ) CP NS 6 Munday et al [21] 2015…”

Section: Discussionmentioning

confidence: 99%

Surveillance of Russell Body Inflammation of the Digestive Tract: A Case Report and Review of Literature

Luo

Huang

et al. 2022

Preprint

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Introduction: Russell body inflammation of the digestive tract (RBIDT) is a rare chronic inflammation of the digestive tract mucosa that commonly presents as Russell body gastritis (RBG). This disease is usually associated with Helicobacter pylori (HP) infection. However, it can also occur in individuals without HP infection and with specific immune profiles, as seen in HIV and hepatitis C infections. The aetiology and pathogenesis of this disease remain controversial. Given the rarity of the disease and the diversity of the immunophenotypes, there is a high probability of misdiagnosis.Case Presentation: A male patient with RBG and HP infection was included in this study. The case of RBG with an unusual morphology of Mott cells that mimics stamped ring cells.Endoscopy performed during the follow-up revealed regression of the lesion 1 week after anti-HP treatment.Conclusion: A case of RBG with a high likelihood of misdiagnosis of signet ring cell carcinoma (SRC) has been reported in this study along with a review of the relevant literature and an overview of RBIDT.

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“…Chen et al [20] 2013 1 59 F Duodenum Yes Polyclonal Diabetes, Hypertension COPD NS 5 zhang et al [9] 2014 1 76 M Duodenum Yes Monoclonal (λ) CP NS 6 Munday et al [21] 2015…”

Section: Discussionmentioning

confidence: 99%

Surveillance of Russell Body Inflammation of the Digestive Tract: A Case Report and Review of Literature

Luo

Huang

et al. 2022

Preprint

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“…Since then, approximately 20 cases of RBG have been reported. RBD is a rare disease, which Savage et al [ 4 ] first reported in a patient positive for HIV; only five cases have since been reported [ 5 - 8 ]. The differential diagnoses include plasmacytoma, mucosa-associated lymphoid tissue lymphoma, and signet ring cell carcinoma.…”

Section: Discussionmentioning

confidence: 99%

“…However, only one of the five previously reported cases of RBD was positive for H. pylori . The other background diseases were HIV infection in one [ 4 ], Crohn disease in one [ 5 ], retroperitoneal metastasis of ureteral cancer in one [ 6 ], and adenocarcinoma of the ascending colon in one case [ 8 ]. Although the development of Russell bodies is assumed to be associated with chronic inflammation, microorganisms, and immunodeficiency, the causes of their development remain unknown.…”

Section: Discussionmentioning

confidence: 99%

Chronological Endoscopic and Pathological Observations in Russell Body Duodenitis

Goto

Okamoto

Matsumoto³

et al. 2016

Clin Endosc

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A 64-year-old man was found to have a nodule in his right lung. He also complained of nausea and abdominal pain during the clinical course. Esophagogastroduodenoscopy revealed a duodenal ulcer associated with severe stenosis and a suspicion of malignancy. However, three subsequent biopsies revealed no evidence of malignancy. The fourth biopsy showed scattered large eosinophilic cells with an eccentric nucleus, leading to a diagnosis of Russell body duodenitis (RBD). RBD is an extremely rare disease, and little is known about its etiology and clinical course. The pathogenesis of RBD is discussed based on our experience with this case.

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“…1-3 ▸ It is generally considered a benign entity, but given its epidemiology and the fact that Mott cells are associated with certain haematological malignancies such as multiple myeloma, plasmacytoma and mucosaassociated lymphoid tissue (MALT) lymphoma, there is still some doubts concerning its true clinical significance, particularly regarding the risk for gastric cancer development and so, follow-up is mandatory. [1][2][3] …”

Section: Descriptionmentioning

confidence: 99%