Russell &amp; Rubinstein's Pathology of Tumors of the Nervous System 7Ed

McLendon, Roger E.; Rosenblum, Marc K.; Bigner, Darell

doi:10.1201/b13439

Cited by 101 publications

(99 citation statements)

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“…We therefore assessed whether ATF5 might be expressed in highly proliferative glial tumors. A series of 29 surgically resected human GBM tumors (WHO Grade IV) were immunostained with ATF5 antiserum (Kleihues et al, 1993;McLendon et al, 1998). All stained materials were examined by a neuropathologist (PDC) to verify the GBM diagnosis and to identify the stained cells.…”

Section: Human Glioblastomas Express Nuclear Atf5mentioning

confidence: 99%

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Selective destruction of glioblastoma cells by interference with the activity or expression of ATF5

et al. 2005

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Glioblastoma multifome is the most common and most aggressive primary brain tumor with no current curative therapy. We found expression of the bZip transcription factor ATF5 in all 29 human glioblastomas and eight human and rat glioma cell lines assessed. ATF5 is not detectably expressed by mature brain neurons and astrocytes, but is expressed by reactive astrocytes. Interference with ATF5 function or expression in all glioma cell lines tested causes marked apoptotic cell death. In contrast, such manipulations do not affect survival of ATF5-expressing cultured astrocytes or of several other cell types that express this protein. In a proof-of-principle experiment, retroviral delivery of a function-blocking mutant form of ATF5 into a rat glioma model evokes death of the infected tumor cells, but not of infected brain cells outside the tumors. The widespread expression of ATF5 in glioblastomas and the selective effect of interference with ATF5 function/expression on their survival suggest that ATF5 may be an attractive target for therapeutic intervention in such tumors.

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Section: Human Glioblastomas Express Nuclear Atf5mentioning

confidence: 99%

“…There is currently no effective curative therapy for patients with WHO classification Grade IV glioblastomas (also designated as glioblastoma multiforme (GBM)) and the average survival time from diagnosis is approximately 9-11 months (Kleihues et al, 1993;McLendon et al, 1998).…”

Section: Introductionmentioning

confidence: 99%

Selective destruction of glioblastoma cells by interference with the activity or expression of ATF5

et al. 2005

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“…Four grades of gliomas are recognized by the WHO ranging from grade I tumors, the biologically least aggressive, to grade IV, the biologically most aggressive tumors. The histological criteria for malignancy grading are not uniform for all tumor types and thus all tumors must be classified before the malignancy grade can be determined [1][2][3] . p53 protein is a tumor suppressor gene that plays a key role in cellular response pathways for cell-cycle control apoptosis, genomic stability, senescence, differentiation and angiogenesis.…”

Section: Introductionmentioning

confidence: 99%

Immunohistochemical expression of p53 and p21 in gliomas: a clinicopathological study

Saeed

Jalal

2013

ZJMS

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Background and objective:To evaluate p53 and p21 proteins over expression in gliomas and their relation to some clinico-pathological parameters. Methods: From September 2009 to July 2010, a formalin fixed, paraffin embedded blocks of 60 gliomas cases were collected in addition to 44 astrocytomas, 5 oligodendrogliomas, 2 oligoastrocytomas, and 9 ependymomas. These cases were evaluated by immunohistochemistry using streptavidin-biotin method. Results: Overall, 53% of gliomas were positive for p53; these cases formed 66% of astrocytomas, 20% of oligodendrogliomas and 100% of oligoastrocytomas. In contrast to astrocytomas, all ependymoma cases were negative for p53 protein. There was a significant association of p53 expression with patient's age and tumor site. On the other hand, p21 expression was positive in 25% of gliomas; they comprised 23% of astrocytomas, 40% of oligodendrogliomas, 50% of oligoastrocytomas and 22% of ependymomas. Both p53 and p21 expressions seemed to be raising from low to high grades astrocytoma but they did not reach level of significance. Conclusion:The results of the present study suggest that p53 overexpression is common in gliomas and p21 expression is less common. There was a trend of both marker expressions increasing with higher grades.

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“…Epidermoid cysts have concentric lamellated internal architecture due to continuous accretion of keratin debris produced by the epithelium (12). These cysts are lined by thin squamous epithelium and are filled with debris formed from the desquamation of the epithelial lining.…”

Section: Discussionmentioning

confidence: 99%

Diffusion tensor and tensor metrics imaging in intracranial epidermoid cysts

Kannath

Radhakrishnan

Saini

et al. 2009

Magnetic Resonance Imaging

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Purpose:To explore the utility of diffusion tensor imaging (DTI) and diffusion tensor metrics (DTM) in characterizing the structural pathology of epidermoid cysts. DTI gives information about the tissue structure; a high fractional anisotropy (FA) indicates a highly structured orientation of the tissue, fibers, or white matter tracts. Based on the tensor rank, a set of three metrics has been described that can be used to measure the directional dependence of diffusion: linear anisotropy (CL), planar anisotropy (CP), and spherical anisotropy (CS). DTM takes into account the shape of diffusion anisotropy and hence may provide better insight into the orientation of structures than FA.Materials and Methods: DTI was performed in three patients with epidermoid cysts. FA, directionally-averaged mean diffusivity (Dav), exponential apparent diffusion coefficient (eADC), and DTM, such as CL, CP, and CS, were measured from the tumor core as well as from the normalappearing white matter. Histopathological correlation was obtained. Results:Epidermoid cysts showed high FA with Dav values similar to that of normal white matter. eADC maps did not show any restriction of diffusion. FA values were high, but not as high as that for the white matter. CP values were higher and CL values were lower than those obtained for the white matter in various regions. Conclusion:High CP values suggest preferential diffusion of water molecules along a two-dimensional geometry, which could be attributed to the well-structured orientation of keratin filaments and flakes within the tumor as demonstrated by histopathology. Advanced imaging modalities like DTI with DTM can provide information regarding the microstructural anatomy of the epidermoid cysts.

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Russell & Rubinstein's Pathology of Tumors of the Nervous System 7Ed

Cited by 101 publications

References 0 publications

Selective destruction of glioblastoma cells by interference with the activity or expression of ATF5

Selective destruction of glioblastoma cells by interference with the activity or expression of ATF5

Immunohistochemical expression of p53 and p21 in gliomas: a clinicopathological study

Diffusion tensor and tensor metrics imaging in intracranial epidermoid cysts

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