Rush oral immunotherapy in children with persistent cow's milk allergy

Oral immunotherapy for the treatment of food allergy

“…In 2008, Staden and colleagues published their experience of hospitalizing 9 children in Germany, aged 3-14 y, with IgE mediated cow's milk allergy confirmed by DBPCFC. 48 The first dose was 1/100th of the eliciting dose for objective symptoms during the DBPCFC. Doses were then doubled every 2 h, with 3-5 doses during one day, with escalations up to 7 d to reach 120 mL (4g) of cow's milk or highest individual dose tolerated.…”

Current opinion and review on peanut oral immunotherapy

“…18 Reports of the efficacy of oral immunotherapy (OIT) to numerous foods received some attention in the 1980s and 1990s. [19][20][21] Over the last decade investigators in the US and Europe have expanded research protocols specifically investigating OIT for the treatment of milk, [22][23][24][25] egg [26][27][28][29][30] and peanut allergy. [31][32][33][34][35][36][37][38][39] In 2009, results from a multicenter US open label study demonstrating successful desensitization to peanut protein in 27 out of 29 subjects was published.…”

Food Allergy in Atopic Dermatitis

“…They used IFN- as the adjuvant for oral immunotherapy for food allergy and named this therapy "specific oral tolerance induction (SOTI)" in 2003. SOTI was attempted for IgE-mediated food allergy in humans by several investigators [5,34,[39][40][41][42][43]. The complete SOTI protocol for IgE-mediated food allergy was accomplished by also using IFN- in 2009 by Noh & Lee [6].…”