Ruscodibenzoruran, a new dibenzofuran from Ruscus aculeatus l. (liliaceae)

New Benzofuran Oligomers from the Roots of Eupatorium heterophyllum Collected in China

“…The structures of 34 known compounds, including 24 benzofurans (6 [23], 7 [31], 8 [8], 9 [25], 10 [32], 11 [29], 12 [33], 13 [25], 15 [22,23], 16 [34], 18 [35], 19 [26], 20 [36], 22 [15,37], 23 [8], 24 [8], 27 [24], 28 [38], 29 [8], 30 [39], 33 [6], 35 [40], 37 [6], and 38 [6]), 4 thiophenes (40 [41], 41 [41], 42 [8], 43 [6]), 2 triterpenoids (44 [42] and 45 [43]), and 4 other aromatic compounds (46 [44], 47 [45], 48 [46], 49 [47]) were identified by comparing their NMR data with those reported in the literature (Figure 9).…”

Halogenation of phenols and phenyl ethers with potassium halides in the presence of 18-crown-6 on oxidation with m-chloroperbenzoic acid

“…Olivetol dimethyl ether (9) presented a similar picture. Our reagent produced 2-bromo-1,5-dimethoxy-3-pentylbenzene (10) in 82% yield with traces of the 2,4-dibromo compound (20).…”

“…(b) Bromination of olivetol dimethyl ether (9). 2-Bromo-1 3dimethoxy-3-pentylbenzene(10) was obtained in 20% yield; 2,4dibromo-1,5-dimethoxy-3-pentylbenzene (20) was obtained in 40% yield, as crystals, m.p. 73-74 "C; G(CDC1,) 3.89 (6 H, s, OMe) and 6.40 (1 H, s, 6-H) (lit.,8 m.p.…”

Syntheses of the natural dibenzofuran, ruscodibenzofuran

“…2 The natural occurrence of dibenzofurans, particularly within higher plants is comparatively rare.3 Although these workers demonstrated from spectroscopic data and X-ray diffraction analysis that ruscodibenzofuran had the composition 8-acetyl-7-hydroxy-l,4-dimethyldibenzofuran (l), an attempted synthesis employing a mixed Ullmann reaction was unsuccessful. 2 The natural occurrence of dibenzofurans, particularly within higher plants is comparatively rare.3 Although these workers demonstrated from spectroscopic data and X-ray diffraction analysis that ruscodibenzofuran had the composition 8-acetyl-7-hydroxy-l,4-dimethyldibenzofuran (l), an attempted synthesis employing a mixed Ullmann reaction was unsuccessful.…”

“…From the roots of Ruscus aculeatus L. (Liliaceae), an evergreen shrub yielding extracts for which a variety of medicinal effects have been claimed, ElSohly and co-workers isolated a dibenzofuran which they subsequently named ruscodibenzofuran. 2 The natural occurrence of dibenzofurans, particularly within higher plants is comparatively rare.3 Although these workers demonstrated from spectroscopic data and X-ray diffraction analysis that ruscodibenzofuran had the composition 8-acetyl-7-hydroxy-l,4-dimethyldibenzofuran (l), an attempted synthesis employing a mixed Ullmann reaction was unsuccessful. Within a short period, however, three distinct syntheses were successfully completed.…”