This research has been an attempt to study the Quality of Life (QoL) in rural regions of Tehran, which is one of the metropolises of Iran. This survey study applied a non-experimental method in rural regions of Tehran, i.e., the causal-correlational approach, which has studied the status of QoL and its relationship with general health and life satisfaction. The statistical population of the study included 61402 households. A multi-stage random sampling method was used for sampling (n=382). The findings revealed that among the four aspects of QoL, physical health (with an average of 3.62) had the highest rank. Furthermore, the psychological health, social relations, and environmental situation were in the second to fourth ranks, respectively, with an average of 3.37, 3.17, and 3.15. The results revealed that the total score of QoL in the range of 4-20 was equal to 13.31, and in the range of 0-100, it was 58.18. Therefore, the QoL in rural areas of the metropolis of Tehran is not desirable and needs urgent care. The results of this research can be used to prioritize policy-making and planning for rural development and the achievement of millennial goals.