Rural environment reduces allergic inflammation by modulating the gut microbiota

Yang, Zujun; Chen, Zhong; Lin, Xinliu; Yao, Siyang; Xian, Ming; Ning, Xiaoping; Fu, Wanyi; Jiang, Mei; Li, Naijian; Xiao, Xiaojun; Feng, Mulin; Lian, Zexuan; Yang, Wenqing; Ren, Xiangxia; Zheng, Zhenyu; Zhao, Jiefeng; Wei, Nili; Lu, Wenju; Roponen, Marjut; Schaub, Bianca; Wong, Gary K. W.; Su, Zhendong; Wang, Charles; Li, Jing

doi:10.1080/19490976.2022.2125733

Cited by 17 publications

(13 citation statements)

References 61 publications

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“…Further mechanistic studies demonstrated that dust from urban households had lower microbial diversity but higher proportions of potentially pathogenic bacteria and the allergenic fungal genus Aspergillus compared with dust from rural households and poultry stables. 91 The asthma-protective effect of rural upbringing can be reproduced in urban settings by having similar indoor dust bacterial/archaeal microbiota. 92 These findings provide a direction for the development of novel approaches to prevent asthma in the urban setting.…”

Section: Environmental Exposure and Microbial Colonizationmentioning

confidence: 99%

“…The discrepancy between studies might be attributable to differences in the classification of disease phenotypes (5‐year asthma vs. early‐life wheeze). Further mechanistic studies demonstrated that dust from urban households had lower microbial diversity but higher proportions of potentially pathogenic bacteria and the allergenic fungal genus Aspergillus compared with dust from rural households and poultry stables 91 . The asthma‐protective effect of rural upbringing can be reproduced in urban settings by having similar indoor dust bacterial/archaeal microbiota 92 .…”

Section: Interactions Between Microbiome and Asthmamentioning

confidence: 99%

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From preschool wheezing to asthma: Environmental determinants

Xing,

Leung,

Wong

2023

Pediatric Allergy Immunology

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Wheezing is common among preschool children, representing a group of highly heterogeneous conditions with varying natural history. Several phenotypes of wheezing have been proposed to facilitate the identification of young children who are at risk of subsequent development of asthma. Epidemiological and immunological studies across different populations have revealed the key role of environmental factors in influencing the progression from preschool wheezing to childhood asthma. Significant risk factors include severe respiratory infections, allergic sensitization, and exposure to tobacco smoke. In contrast, a farming/rural environment has been linked to asthma protection in both human and animal studies. Early and intense exposures to microorganisms and microbial metabolites have been demonstrated to alter host immune responses to allergens and viruses, thereby driving the trajectory away from wheezing illness and asthma. Ongoing clinical trials of candidate microbes and microbial products have shown promise in shaping the immune function to reduce episodes of viral‐induced wheezing. Moreover, restoring immune training may be especially important for young children who had reduced microbial exposure due to pandemic restrictions. A comprehensive understanding of the role of modifiable environmental factors will pave the way for developing targeted prevention strategies for preschool wheezing and asthma.

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Section: Environmental Exposure and Microbial Colonizationmentioning

confidence: 99%

Section: Interactions Between Microbiome and Asthmamentioning

confidence: 99%

From preschool wheezing to asthma: Environmental determinants

Xing,

Leung,

Wong

2023

Pediatric Allergy Immunology

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“…Tenericutes, primarily 'NB1-n' (SILVA taxonomy) or 'RF3' (Greengenes taxonomy), indicated a decreased abundance in Pglyrp1−/− mice with a lower asthmatic response (Skennerton et al, 2016;Banskar et al, 2019). For Ruminiclostridium, a recent study found that intranasal delivery of rural dusts decreased eosinophils and plasma IgE levels in mice and contributed to a recovery of gut microbiota diversity and Ruminiclostridium in a mouse model, suggesting that exposure to Ruminiclostridium may promote allergy management (Yang et al, 2022).…”

Section: Discussionmentioning

confidence: 99%

The associations between gut microbiota and chronic respiratory diseases: a Mendelian randomization study

Shi¹,

Zhao²,

Geng³

et al. 2023

Front. Microbiol.

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IntroductionGrowing evidence indicates that variations in the composition of the gut microbiota are linked to the onset and progression of chronic respiratory diseases (CRDs), albeit the causal relationship between the two remains unclear.MethodsWe conducted a comprehensive two-sample Mendelian randomization (MR) analysis to investigate the relationship between gut microbiota and five main CRDs, including chronic obstructive pulmonary disease (COPD), asthma, idiopathic pulmonary fibrosis (IPF), sarcoidosis, and pneumoconiosis. For MR analysis, the inverse variance weighted (IVW) method was utilized as the primary method. The MR–Egger, weighted median, and MR-PRESSO statistical methods were used as a supplement. To detect heterogeneity and pleiotropy, the Cochrane and Rucker Q test, MR–Egger intercept test, and MR-PRESSO global test were then implemented. The leave-one-out strategy was also applied to assess the consistency of the MR results.ResultsBased on substantial genetic data obtained from genome-wide association studies (GWAS) comprising 3,504,473 European participants, our study offers evidence that several gut microbial taxa, including 14 probable microbial taxa (specifically, 5, 3, 2, 3 and 1 for COPD, asthma, IPF, sarcoidosis, and pneumoconiosis, respectively) and 33 possible microbial taxa (specifically, 6, 7, 8, 7 and 5 for COPD, asthma, IPF, sarcoidosis, and pneumoconiosis, respectively) play significant roles in the formation of CRDs.DiscussionThis work implies causal relationships between the gut microbiota and CRDs, thereby shedding new light on the gut microbiota-mediated prevention of CRDs.

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“…Urban living compared to rural living, in the USA, has been linked to a doubled risk of peanut and shellfish allergies ( 106 ). We assert that in addition to environmental factors and gut microbiome diversity contributing to reduced risk of allergy in rural settings ( 107 – 109 ), more fresh, whole foods and less dAGE burden are also important factors. “Food deserts” describe urban areas where fresh food is hard to obtain, more fast food is consumed, and there are greater rates of obesity.…”

Section: Epidemiological Associationsmentioning

confidence: 99%

Do advanced glycation end products contribute to food allergy?

et al. 2023

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Sugars can bind non-enzymatically to proteins, nucleic acids or lipids and form compounds called Advanced Glycation End Products (AGEs). Although AGEs can form in vivo, factors in the Western diet such as high amounts of added sugars, processing methods such as dehydration of proteins, high temperature sterilisation to extend shelf life, and cooking methods such as frying and microwaving (and reheating), can lead to inordinate levels of dietary AGEs. Dietary AGEs (dAGEs) have the capacity to bind to the Receptor for Advanced Glycation End Products (RAGE) which is part of the endogenous threat detection network. There are persuasive epidemiological and biochemical arguments that correlate the rise in food allergy in several Western countries with increases in dAGEs. The increased consumption of dAGEs is enmeshed in current theories of the aetiology of food allergy which will be discussed.

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Rural environment reduces allergic inflammation by modulating the gut microbiota

Cited by 17 publications

References 61 publications

From preschool wheezing to asthma: Environmental determinants

From preschool wheezing to asthma: Environmental determinants

The associations between gut microbiota and chronic respiratory diseases: a Mendelian randomization study

Do advanced glycation end products contribute to food allergy?

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