A ganglion cyst is the cystic lesion originates from the joint capsule or tendon sheath. This lesion is the most common soft tissue tumors of hand, wrist, and foot, and frequently observed in women between 30-50 years. A peroneal ganglion cyst is an uncommon lesion and rarely composes peroneal neuropathic symptoms. We report a 37-year-old man with swelling at the lateral portion of knee below, foot pain, loss of sensation at the lateral portion of left inferior cruris. Ultrasound (US) and magnetic resonance imaging (MRI) findings demonstrated a large cystic lesion in the peroneal muscle, and preliminary diagnosis of peroneal ganglion cyst was proved by cytology. The patient was asymptomatic one month after surgery. There was no evidence of residue or recurrence on US imaging after 6 months.