Ruptured Internal Carotid Pseudoaneurysm in a Nasopharyngeal Carcinoma Patient with Skull Base Osteoradionecrosis

Chen, Hsin-Chien; Lin, Chao-Jung; Jen, Yee‐Min; Juan, Chun-Jung; Hsueh, Chun-Jen; Lee, Jin-Chin; Su, Wan‐Fu

doi:10.1016/j.otohns.2003.08.010

Cited by 32 publications

(21 citation statements)

References 5 publications

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“…Radiation obliterates the vasa vasorum and causes premature atherosclerosis, adventitial fibrosis, and weakening and necrosis of the arterial wall. The results of many studies about osteoradionecrosis show that the dosage was highly related with the occurrence of skull base osteoradionecrosis[11],[14]–[16]. Of the 67 patients studied here, 27 underwent two courses of radiotherapy and 12 underwent IMRT.…”

Section: Discussionmentioning

confidence: 98%

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Clinical findings and imaging features of 67 nasopharyngeal carcinoma patients with postradiation nasopharyngeal necrosis

Chen¹,

Qiang²,

Sun³

et al. 2013

Chin J Cancer

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Postradiation nasopharyngeal necrosis is an important late effect of radiotherapy that affects prognosis in patients with nasopharyngeal carcinoma. In the present study, we reviewed the clinical and imaging features of 67 patients with pathologically diagnosed postradiation nasopharyngeal necrosis who were treated at Sun Yat-sen University Cancer Center between June 2006 and January 2010. Their clinical manifestations, endoscopic findings, and imaging features were analyzed. Early nasopharyngeal necrosis was limited to a local site in the nasopharyngeal region, and the tissue defect was not obvious, whereas deep parapharyngeal ulcer or signs of osteoradionecrosis in the basilar region was observed in serious cases. Those with osteoradionecrosis and/or exposed carotid artery had a high mortality. In conclusion, Postradiation nasopharyngeal necrosis has characteristic magnetic resonance imaging appearances, which associate well with clinical findings, but pathologic examination is essential to make the diagnosis.

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Section: Discussionmentioning

confidence: 98%

“…Hemorrhage, a fatal event, is closely associated with radiation-induced nasopharyngeal necrosis. Weakening of the wall of postirradiated vessels may result in dissection or rupture and produce a pseudoaneurysm[11],[12]. Without immediate treatment in a hospital, rupture can be fatal because of the anatomy of the nasopharynx.…”

Section: Discussionmentioning

confidence: 99%

Clinical findings and imaging features of 67 nasopharyngeal carcinoma patients with postradiation nasopharyngeal necrosis

Chen¹,

Qiang²,

Sun³

et al. 2013

Chin J Cancer

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show abstract

“…The results of a series study about osteoradionecrosis show that the dosage is highly related with the occurrence of skull base osteoradionecrosis. [7][8][9][10] Of 28 patients studied here, 14 patients received 2 courses of radiotherapy and the accumulating prescribed dose for the nasopharynx was more than 120 Gy. In the patients treated with IMRT, the dose for the nasopharynx was more than 80 Gy.…”

Section: Discussionmentioning

confidence: 99%

Postradiation nasopharyngeal necrosis in the patients with nasopharyngeal carcinoma

et al. 2009

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“…Ruptured internal carotid pseudoaneurysm with an osteoradionecrotized bone has also been reported by Chen et Al 2 . Radiotherapy likely played a major part in this erosion by weakening the arterial wall, as is often described in literature 2,3,4,5 . The intermittence of bleeding episodes resulted in a twomonth delay in the diagnosis.…”

Section: Discussionmentioning

confidence: 75%

Pseudoaneurysm of Internal Carotid Artery following Mandibular Reconstruction Treated by Covered Stent

Mejdoubi

Dekeister

Irsutti³

et al. 2006

Interv Neuroradiol

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We describe the case of a 68-year-old woman who had a mandibular titanium plate reconstruction following surgery for a parotid carcinoma. Fifteen months later she presented bleeding episodes related to a pseudoaneurysm of the internal carotid artery located just above the bulb. This was probably related to the weakening of the arterial wall following friction with the mandibular plate and radiotherapy. We successfully obliterated this pseudoaneurysm using a covered stent. This rare diagnosis should be evoked in case of bleeding following a mandibular reconstruction. Stenting is an effective treatment strategy obviating the need for open surgery.

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Ruptured Internal Carotid Pseudoaneurysm in a Nasopharyngeal Carcinoma Patient with Skull Base Osteoradionecrosis

Cited by 32 publications

References 5 publications

Clinical findings and imaging features of 67 nasopharyngeal carcinoma patients with postradiation nasopharyngeal necrosis

Clinical findings and imaging features of 67 nasopharyngeal carcinoma patients with postradiation nasopharyngeal necrosis

Postradiation nasopharyngeal necrosis in the patients with nasopharyngeal carcinoma

Pseudoaneurysm of Internal Carotid Artery following Mandibular Reconstruction Treated by Covered Stent

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