“…Yet the frequency of ectopic and heterotopic pregnancies has increased in the last half century due to advancements in reproductive technology and an increasing rate of pelvic inflammatory disease (3)(4)(5)13). The incidence of heterotopic pregnancy in patients assisted by reproductive technology has been reported as between 1:100 and 1:500, and estimates in the general population are between 1:2600 and 1:8000 (5,6,13,14). Other risk factors for ectopic (and likely heterotopic) pregnancy include previous ectopic pregnancy, fallopian tube surgery, treatment with superovulation medication (such as clomiphene citrate), Deithylstilbestrol exposure before birth, and possibly endometriosis and cigarette smoking (14).…”