Background: Ectopic pregnancy can be life-threatening. Most of ectopic pregnancy located in the fallopian tube. But retroperitoneal ectopic pregnancies are extremely rare.Results: We report a 29-year-old Chinese woman with amenorrhea for 50 days presented to emergency department for abdominal pain. Her serum β-hCG level was 1675mIU/ml. Transvaginal sonography showed irregular anechoic area in uterine cavity without pregnancy sac echo. And nothing wrong was found in bilateral adnexa. Abdominal ultrasound showed a mixed echo region behind the pancreas. The clinical diagnosis was retroperitoneal ectopic pregnancy. The patient's vital signs remained stable with the mass size continue decreased . Because of the huge surgery risk, the mass was followed up by ultrasound closely.Conclusions: 5 months after bleeding, the fourth ultrasound follow-up examination showed the mass disappeared completely and serum β-hCG level was normal .