RUNX3 inhibits the proliferation and metastasis of gastric cancer through regulating miR-182/HOXA9

Yu, Junyan; Tian, Xiangyang; Chang, Jianlan; Liu, Ping; Zhang, Rong

doi:10.1016/j.biopha.2017.08.144

Cited by 30 publications

(24 citation statements)

References 41 publications

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“…HOXB7 mediates GC cell malignancy by activating AKT/MAPK signalling, Src-FAK pathway, PIK3R3/AKT pathway, and epithelial mesenchymal transition (EMT) [26,49,50]. The miR-182/HOXA9 axis is implicated in RUNX3-mediated GC development [51]. In addition, HOXC9 contributes to GC progression by inducing EMT, MMP2 expression, and stem cell-like properties [29].…”

Section: Mechanisms By Which Hox Proteins Regulate Gcmentioning

confidence: 99%

Homeobox proteins are potential biomarkers and therapeutic targets in gastric cancer: a systematic review and meta-analysis

Jin

Dai

et al. 2020

BMC Cancer

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Background An increasing number of studies have described the aberrant expression of homeobox (HOX) proteins in gastric cancer (GC), which is critically associated with the prognosis and clinicopathological characteristics of GC. This study was conducted to investigate the clinical value and action mechanisms of HOX proteins in GC. Methods A comprehensive search of PubMed, Embase, Web of Science and Cochrane Library was performed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) statement. The pooled hazard ratio (HR) with its 95% confidence interval (95% CI) and the pooled odds ratio (OR) with its 95% CI were used to assess the effect of HOX protein expression on the prognosis and clinicopathological features of GC, respectively. Results Nineteen studies containing 3775 patients were selected for this study. Heterogeneity among HRs of overall survival (OS) was markedly high (I2 = 90.5%, p = 0.000). According to the subgroup analysis, increased expression of HOX protein in the downregulated subgroup was associated with a good prognosis for patients with GC (pooled HR: 0.46, 95% CI: 0.36–0.59, I2 = 3.1%, p = 0.377), while overexpression of HOX protein in the upregulated subgroup was correlated with a reduced OS (pooled HR: 2.59, 95% CI: 1.79–3.74, I2 = 73.5%, p = 0.000). The aberrant expression of HOX protein was crucially related to the TNM stage, depth of tumour invasion, tumour size, lymph node metastasis, distant metastasis, vascular invasion, histological differentiation and Lauren classification in patients with GC. In addition, the molecular mechanisms by which HOX proteins regulate tumorigenesis and development of GC were also explored. Conclusions HOX proteins play vital roles in GC progression, which might serve as prognostic markers and therapeutic targets for GC.

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Section: Mechanisms By Which Hox Proteins Regulate Gcmentioning

confidence: 99%

Homeobox proteins are potential biomarkers and therapeutic targets in gastric cancer: a systematic review and meta-analysis

Jin

Dai

et al. 2020

BMC Cancer

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“…miR-182 has been reported in various cancers, such as lung cancer, 24 CRC, 25 , 26 gastric cancer, 27 and breast cancer. 28 Li et al demonstrated miR-182 could inhibit the epithelial-to-mesenchymal transition (EMT) and the metastasis of lung cancer cells by targeting the Met gene.…”

Section: Discussionmentioning

confidence: 99%

Elevated circulating miR-182 acts as a diagnostic biomarker for early colorectal cancer

Liu

et al. 2018

CMAR

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PurposeGlobally, colorectal cancer (CRC) is one of the most common cancers with high mortality. Although CRC patients in stages I–II are curable after surgical resection, due to the lack of sensitive and specific biomarkers, many patients are in the advanced stages when diagnosed. This study aimed to investigate whether circulating miRNAs in plasma could act as biomarkers for early CRC diagnosis.Patients and methodsAll healthy subjects and patients were from Nanjing First Hospital. We first selected 2 differential miRNAs by integrated analysis of 4 Gene Expression Omnibus (GEO) data sets and The Cancer Genome Atlas (TCGA) database. Next, the expression of these 2 miRNAs in tissue and plasma samples were examined through quantitative real-time polymerase chain reaction. Training phase and validation phase were designed to investigate the diagnostic utility of these differential miRNAs using receiver operating characteristic (ROC) curve analysis.ResultsAfter integrated analysis of 4 GEO and TCGA databases, upregulated miR-182 and miR-20a were selected to further investigate their diagnostic potential for CRC. We discovered that miR-182 and miR-20a were upregulated in CRC tissue and plasma and that circulating miR-182 and miR-20a in the plasma of CRC patients were tumor derived. The area under the ROC curve (AUC) of circulating miR-182 was 0.929 (95% CI 0.875–0.983) in the training phase and 0.891 (95% CI 0.821–0.961) in the validation phase. The AUC of circulating miR-20a expression was 0.801 (95% CI 0.695–0.906) in the training phase and 0.736 (95% CI 0.631–0.842) in the validation phase.ConclusionCirculating miR-182 is a novel potential biomarker for early CRC diagnosis.

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“…HOXB7 mediates GC cell malignancy by activating AKT/MAPK signalling, Src-FAK pathway, PIK3R3/AKT pathway, and epithelial mesenchymal transition (EMT) (26,49,50). The miR-182/HOXA9 axis is implicated in RUNX3-mediated GC development (51). In addition, HOXC9 contributes to GC progression by inducing EMT, MMP2 expression, and stem cell-like properties (29).…”

Section: Hoxc6 Enhances Invasive and Metastatic Abilities Of Gc Cellsmentioning

confidence: 99%

Homeobox proteins are potential biomarkers and therapeutic targets in gastric cancer: a systematic review and meta-analysis

Jin

Dai

et al. 2020

Preprint

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Background: An increasing number of studies have described the aberrant expression of homeobox (HOX) proteins in gastric cancer (GC), which is critically associated with the prognosis and clinicopathological characteristics of GC. This study was conducted to investigate the clinical value and action mechanisms of HOX proteins in GC. Methods: A comprehensive search of PubMed, Embase, Web of Science and Cochrane Library was performed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) statement. The pooled hazard ratio (HR) with its 95% confidence interval (95% CI) and the pooled odds ratio (OR) with its 95% CI were used to assess the effect of HOX protein expression on the prognosis and clinicopathological features of GC, respectively. Results: Nineteen studies containing 3775 patients were selected for this study. Heterogeneity among HRs of overall survival (OS) was markedly high (I2=90.5%, p=0.000). According to the subgroup analysis, increased expression of HOX protein in the downregulated subgroup was associated with a good prognosis for patients with GC (pooled HR: 0.46, 95% CI: 0.36-0.59, I2=3.1%, p=0.377), while overexpression of HOX protein in the upregulated subgroup was correlated with a reduced OS (pooled HR: 2.59, 95% CI: 1.79-3.74, I2=73.5%, p=0.000). The aberrant expression of HOX protein was crucially related to the TNM stage, depth of tumour invasion, tumour size, lymph node metastasis, distant metastasis, vascular invasion, histological differentiation and Lauren classification in patients with GC. In addition, the molecular mechanisms by which HOX proteins regulate tumorigenesis and development of GC were also explored. Conclusions: HOX proteins play vital roles in GC progression, which might serve as prognostic markers and therapeutic targets for GC.

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RUNX3 inhibits the proliferation and metastasis of gastric cancer through regulating miR-182/HOXA9

Cited by 30 publications

References 41 publications

Homeobox proteins are potential biomarkers and therapeutic targets in gastric cancer: a systematic review and meta-analysis

Homeobox proteins are potential biomarkers and therapeutic targets in gastric cancer: a systematic review and meta-analysis

Elevated circulating miR-182 acts as a diagnostic biomarker for early colorectal cancer

Homeobox proteins are potential biomarkers and therapeutic targets in gastric cancer: a systematic review and meta-analysis

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