Runx3 Induces a Cell Shape Change and Suppresses Migration and Metastasis of Melanoma Cells by Altering a Transcriptional Profile

Wang, Ning; Zhang, Haiying; Cui, Xiulin; Ma, Chao; Wang, Linghui; Liu, Wenguang

doi:10.3390/ijms22042219

Cited by 3 publications

(1 citation statement)

References 69 publications

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“…Contrary to other RUNX family members predominantly implicated in the enhancement of metastasis, RUNX3 manifests an opposing role. Research conducted by Wang et al corroborated RUNX3's tumor-suppressive role in melanoma, particularly in inhibiting cell migration and metastasis [ 169 ]. In renal cell carcinoma, Zheng et al demonstrated that the downregulation of both RUNX3 and TGF-β in metastatic tissues, attributed to hypermethylation of CpG islands, is significantly associated with metastatic propensity and can be reversed by the application of a methylation inhibitor [ 85 ].…”

Section: Runx Family and The Intricate Landscape Of Tumor Metastasismentioning

confidence: 99%

RUNX transcription factors: biological functions and implications in cancer

Chen,

Wang,

Yang

et al. 2024

Clin Exp Med

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Runt-related transcription factors (RUNX) are a family of transcription factors that are essential for normal and malignant hematopoietic processes. Their most widely recognized role in malignancy is to promote the occurrence and development of acute myeloid leukemia. However, it is worth noting that during the last decade, studies of RUNX proteins in solid tumors have made considerable progress, suggesting that these proteins are directly involved in different stages of tumor development, including tumor initiation, progression, and invasion. RUNX proteins also play a role in tumor angiogenesis, the maintenance of tumor cell stemness, and resistance to antitumor drugs. These findings have led to the consideration of RUNX as a tumor biomarker. All RUNX proteins are involved in the occurrence and development of solid tumors, but the role of each RUNX protein in different tumors and the major signaling pathways involved are complicated by tumor heterogeneity and the interacting tumor microenvironment. Understanding how the dysregulation of RUNX in tumors affects normal biological processes is important to elucidate the molecular mechanisms by which RUNX affects malignant tumors.

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Section: Runx Family and The Intricate Landscape Of Tumor Metastasismentioning

confidence: 99%

RUNX transcription factors: biological functions and implications in cancer

Chen,

Wang,

Yang

et al. 2024

Clin Exp Med

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Immune escape and metastasis mechanisms in melanoma: breaking down the dichotomy

Shirley,

Chhabra,

Amiri

et al. 2024

Front. Immunol.

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Melanoma is one of the most lethal neoplasms of the skin. Despite the revolutionary introduction of immune checkpoint inhibitors, metastatic spread, and recurrence remain critical problems in resistant cases. Melanoma employs a multitude of mechanisms to subvert the immune system and successfully metastasize to distant organs. Concerningly, recent research also shows that tumor cells can disseminate early during melanoma progression and enter dormant states, eventually leading to metastases at a future time. Immune escape and metastasis have previously been viewed as separate phenomena; however, accumulating evidence is breaking down this dichotomy. Recent research into the progressive mechanisms of melanoma provides evidence that dedifferentiation similar to classical epithelial to mesenchymal transition (EMT), genes involved in neural crest stem cell maintenance, and hypoxia/acidosis, are important factors simultaneously involved in immune escape and metastasis. The likeness between EMT and early dissemination, and differences, also become apparent in these contexts. Detailed knowledge of the mechanisms behind “dual drivers” simultaneously promoting metastatically inclined and immunosuppressive environments can yield novel strategies effective in disabling multiple facets of melanoma progression. Furthermore, understanding progression through these drivers may provide insight towards novel treatments capable of preventing recurrence arising from dormant dissemination or improving immunotherapy outcomes.

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The role and mechanism of compressive stress in tumor

Tan,

Song,

Zhao

et al. 2024

Front. Oncol.

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Recent research has revealed the important role of mechanical forces in the initiation and progression of tumors. The interplay between mechanical and biochemical cues affects the function and behavior of tumor cells during the development of solid tumors, especially their metastatic potential. The compression force generated by excessive cell proliferation and the tumor microenvironment widely regulates the progression of solid tumor disease. Tumor cells can sense alterations in compressive stress through diverse mechanosensitive components and adapt their mechanical characteristics accordingly to adapt to environmental changes. Here, we summarize the current role of compressive stress in regulating tumor behavior and its biophysical mechanism from the mechanobiological direction.

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Runx3 Induces a Cell Shape Change and Suppresses Migration and Metastasis of Melanoma Cells by Altering a Transcriptional Profile

Cited by 3 publications

References 69 publications

RUNX transcription factors: biological functions and implications in cancer

RUNX transcription factors: biological functions and implications in cancer

Immune escape and metastasis mechanisms in melanoma: breaking down the dichotomy

The role and mechanism of compressive stress in tumor

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