Runx1 is upregulated by STAT3 and promotes proliferation of neonatal rat cardiomyocytes
Shota Suzuki,
Shota Tanaka,
Yusuke Kametani
et al.
Abstract:Though it is well known that mammalian cardiomyocytes exit cell cycle soon after birth, the mechanisms that regulate proliferation remain to be fully elucidated. Recent studies reported that cardiomyocytes undergo dedifferentiation before proliferation, indicating the importance of dedifferentiation in cardiomyocyte proliferation. Since Runx1 is expressed in dedifferentiated cardiomyocytes, Runx1 is widely used as a dedifferentiation marker of cardiomyocytes; however, little is known about the role of Runx1 in… Show more
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