Abstract:Background: Effective targeted therapy is an unmet clinical need for core binding factor-acute myeloid leukemia (CBF-AML) characterized by RUNX1-ETO and CBFb-MYH11 fusions. However, therapeutically targeting oncogenic fusions involving transcription factors remains challenging. Recent studies point to aberrant amino acid metabolisms as actionable therapeutic targets.
Methods: We analyzed the expression of BCAT1in a large cohort of AML patients and a series of AML cell lines. Altered BCAA metabolism was assesse… Show more
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