“…Recently, Bresciani and colleagues reported that RUNX1 can drive the emergence of nascent hematopoietic stem cells without its heterodimeric partner CBFb (24), suggesting parts of RUNX1's biologic functions are independent of CBFb. In addition, lots of cellular proteins, Myb, Ets, ALY, TLE/Groucho, p300, CBP, YAP, SIN3A, MOZ, PML, PRMT1, TAL1, MLL, Shp2, SWI/SNF, etc., have been described to interact with RUNX1 (25). Of note, RUNX1 interacted with several transcriptional factors through a dynamic combinatorial mechanism to orchestrate hematopoietic differentiation (26,27).…”