Running throughout middle‐age improves memory function, hippocampal neurogenesis, and BDNF levels in female C57BL/6J mice

Marlatt, Michael W.; Potter, Michelle C.; Lucassen, Paul J.; Praag, Henriette van

doi:10.1002/dneu.22009

Cited by 269 publications

(237 citation statements)

References 55 publications

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“…Intravenous BDNF delivery enhances post-stroke sensorimotor recovery and stimulates neurogenesis [62]. It has also been demonstrated that BDNF up-regulation following exercise is associated with a robust activation of survival pathways that enhance adult neurogenesis in experimental animals [63,64]. Currently, it is unknown whether WBV leads to increases in hippocampal BDNF and whether this response promotes neurogenesis associated with improved cognitive outcome after stroke, but we suspect that this may be the missing link between WBV and exercise.…”

Section: Discussionmentioning

confidence: 99%

Whole Body Vibration Therapy after Ischemia Reduces Brain Damage in Reproductively Senescent Female Rats

Raval¹,

Schatz²,

Bhattacharya³

et al. 2018

Preprint

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A risk of ischemic stroke increases exponentially after menopause. Even a mild-ischemic stroke can result in increased frailty. Frailty is a state of increased vulnerability to adverse outcomes, which subsequently increases risk of cerebrovascular events and severe cognitive decline, particularly after menopause.Several interventions to reduce frailty and subsequent risk of stroke and cognitive decline have been proposed in laboratory animals and patients. One of them is whole body vibration (WBV). WBV improves brain hemodynamics and lessens frailty-related functional and cognitive deterioration. The goal of current study is to test the efficacy of WBV in reducing post-ischemic stroke frailty and brain damage in reproductively senescent female rats. Reproductively senescent Sprague-Dawley female rats were exposed to transient middle cerebral artery occlusion (tMCAO) and randomly assigned to either WBV or control groups. Animals placed in the WBV group underwent 30 days of WBV (40 Hz) treatment performed twice daily for 15 min each session for 5 days each week. The motor functions of animals belonging to both groups were tested intermittently and at the end of treatment period. Brains were then harvested for inflammatory markers and histopathological analysis. The results demonstrate a significant reduction in inflammatory markers, infarct volume, and significant increases in brain-derived neurotrophic factor and improvement in functional activity after tMCAO in middle-aged female rats that were treated with WBV as compared to the control group. Our results may help faster translation of the WBV intervention for improved outcome after stroke, particularly among frail women.

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Section: Discussionmentioning

confidence: 99%

Whole Body Vibration Therapy after Ischemia Reduces Brain Damage in Reproductively Senescent Female Rats

Raval¹,

Schatz²,

Bhattacharya³

et al. 2018

Preprint

View full text Add to dashboard Cite

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“…As expected, this increase in neurogenesis in old exercised animals was associated with an improvement in their abilities in acquiring reference memory in the working memory (WM) compared with sedentary ones (van Praag et al 2005). In addition, exercise starting at the onset and continued throughout middle age also improves spatial memory and enhances neurogenesis (Marlatt et al 2012). Further, exposure of rats to an enriched environment during the prenatal period, the early postnatal period (Koo et al 2003), and adulthood (Nilsson et al 1999) also increased both neurogenesis and spatial learning abilities in the water maze.…”

Section: Correlationsmentioning

confidence: 93%

Interaction between Neurogenesis and Hippocampal Memory System: New Vistas

Abrous

Wojtowicz

2015

Cold Spring Harb Perspect Biol

101

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During the last decade, the questions on the functionality of adult neurogenesis have changed their emphasis from if to how the adult-born neurons participate in a variety of memory processes. The emerging answers are complex because we are overwhelmed by a variety of behavioral tasks that apparently require new neurons to be performed optimally. With few exceptions, the hippocampal memory system seems to use the newly generated neurons for multiple roles. Adult neurogenesis has given the dentate gyrus new capabilities not previously thought possible within the scope of traditional synaptic plasticity. Looking at these new developments from the perspective of past discoveries, the science of adult neurogenesis has emerged from its initial phase of being, first, a surprising oddity and, later, exciting possibility, to the present state of being an integral part of mainstream neuroscience. The answers to many remaining questions regarding adult neurogenesis will come along only with our growing understanding of the functionality of the brain as a whole. This, in turn, will require integration of multiple levels of organization from molecules and cells to circuits and systems, ultimately resulting in comprehension of behavioral outcomes.

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“…While there is still much focus on the signalling mechanisms by which exercise effects are mediated, upregulation of the neurotrophin brain-derived neurotrophic factor (BDNF) has been consistently reported following exercise interventions. Increased expression of hippocampal BDNF and its receptor TrkB has been observed following voluntary wheel running (Gibbons et al, 2014;Kobilo et al, 2011;Marlatt et al, 2012) and forced treadmill exercise Griffin et al, 2009;Wu et al, 1985). At a behavioural level, improvements in spatial learning and memory, associative learning and recognition memory have all been observed in animals following exercise training.…”

Section: Adult Hippocampal Neurogenesis and Exercisementioning

confidence: 99%

Exercise as a pro-cognitive, pro-neurogenic and anti-inflammatory intervention in transgenic mouse models of Alzheimer’s disease

Ryan

Kelly

2016

Ageing Research Reviews

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a b s t r a c tIt is now well established, at least in animal models, that exercise elicits potent pro-cognitive and proneurogenic effects. Alzheimer's disease (AD) is one of the leading causes of dementia and represents one of the greatest burdens on healthcare systems worldwide, with no effective treatment for the disease to date. Exercise presents a promising non-pharmacological option to potentially delay the onset of or slow down the progression of AD. Exercise interventions in mouse models of AD have been explored and have been found to reduce amyloid pathology and improve cognitive function. More recent studies have expanded the research question by investigating potential pro-neurogenic and anti-inflammatory effects of exercise. In this review we summarise studies that have examined exercise-mediated effects on AD pathology, cognitive function, hippocampal neurogenesis and neuroinflammation in transgenic mouse models of AD. Furthermore, we attempt to identify the optimum exercise conditions required to elicit the greatest benefits, taking into account age and pathology of the model, as well as type and duration of exercise.© 2016 Elsevier B.V. All rights reserved. Please cite this article in press as: Ryan, S.M., Kelly, Á.M., Exercise as a pro-cognitive, pro-neurogenic and anti-inflammatory intervention in transgenic mouse models of Alzheimer's disease. Ageing Res. Rev. (2016), http://dx

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Running throughout middle‐age improves memory function, hippocampal neurogenesis, and BDNF levels in female C57BL/6J mice

Cited by 269 publications

References 55 publications

Whole Body Vibration Therapy after Ischemia Reduces Brain Damage in Reproductively Senescent Female Rats

Whole Body Vibration Therapy after Ischemia Reduces Brain Damage in Reproductively Senescent Female Rats

Interaction between Neurogenesis and Hippocampal Memory System: New Vistas

Exercise as a pro-cognitive, pro-neurogenic and anti-inflammatory intervention in transgenic mouse models of Alzheimer’s disease

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