Running enhances spatial pattern separation in mice

Creer, David J.; Romberg, Carola; Saksida, Lisa M.; Praag, Henriette van; Bussey, Timothy J.

doi:10.1073/pnas.0911725107

Cited by 449 publications

(484 citation statements)

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“…We used low-resistance spinning disks, which resulted in increased compliance with only 1 mouse not using the spinning disk out of 48 mice in our study compared to 13 non-exercisers out of 54 mice in Richter and colleagues' study [22]. The low-resistance spinning disks that we used also allowed mice to run longer distances compared to standard metal wheels (9 km/day versus 1.4 km/day) [65]. These experimental differences may be of significance in the search of sufficient levels of physical activity translating into improved cognitive performance.…”

Section: Discussionmentioning

confidence: 99%

A Comparative Study Evaluating the Impact of Physical Exercise on Disease Progression in a Mouse Model of Alzheimer’s Disease

Maliszewska-Cyna

Xhima

Aubert

2016

JAD

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Abstract. Evidence suggests that physical exercise can serve as a preventive strategy against Alzheimer's disease (AD). In contrast, much less is known about the impact of exercise when it is introduced after cognitive deficits are established. Using the TgCRND8 mouse model of amyloidosis, we compared the effects of exercise as an intervention strategy aimed at altering disease progression. Voluntary running for 1 month or 2 months was introduced in 3-month-old TgCRND8 mice, which exhibit amyloid-beta (A␤) plaque pathology and cognitive deficits at this age. Specifically, we examined A␤ plaque load, spatial memory, and neurogenesis in the dentate gyrus in the hippocampus. After 1 month of running, TgCRND8 mice spent more time in the novel arm of the Y-maze compared to the familiar arms, indicating improved memory. The levels of doublecortin (a marker of immature neurons) were increased in TgCRND8 mice running for 1 month, but with no significant difference in the number of new mature neurons or plaque burden. As the disease progressed, running prevented further deficits in the Y-maze performance and hippocampal neurogenesis and it reduced plaque load pathology in TgCRND8 mice running for 2 months, compared to non-running transgenics. Therefore, the impact of running on memory, neurogenesis, and amyloid pathology was of greater significance when sustained through later stages of the disease.

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Section: Discussionmentioning

confidence: 99%

A Comparative Study Evaluating the Impact of Physical Exercise on Disease Progression in a Mouse Model of Alzheimer’s Disease

Maliszewska-Cyna

Xhima

Aubert

2016

JAD

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“…* MWM at low temperature are placed in Table 3. included, among other things, a shift in day-night cycle and various hippocampus-dependent paradigms that could, in theory, have interfered with the present anatomical and neurogenesis 'end-stage' data. Changes in proliferation and DG structure may further affect downstream processing within the hippocampus and alterations in neurogenesis have indeed been linked to cognitive changes (Clelland et al, 2009;Creer et al, 2010;Aimone et al, 2011;Sahay et al, 2011a,b;Oomen et al, 2014). Neurogenesis may be relevant for some, but not all forms of hippocampal-dependent learning and memory (Saxe et al, 2006;Zhang et al, 2008;Clelland et al, 2009;Kitamura et al, 2009;Oomen et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

Effects of early-life stress on cognitive function and hippocampal structure in female rodents

et al. 2017

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Effects of early-life stress on cognitive function and hippocampal structure in female rodents Loi, M.; Mossink, J.C.L.; Meerhoff, G.F.; den Blaauwen, J.L.; Lucassen, P.J.; Joëls, M. General rightsIt is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), other than for strictly personal, individual use, unless the work is under an open content license (like Creative Commons). Disclaimer/Complaints regulationsIf you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the Library know, stating your reasons. In case of a legitimate complaint, the Library will make the material inaccessible and/or remove it from the website. Please Ask the Library: http://uba.uva.nl/en/contact, or a letter to: Library of the University of Amsterdam, Secretariat, Singel 425, 1012 WP Amsterdam, The Netherlands. You will be contacted as soon as possible. Abstract-We tested the effect of early-life stress (ELS) -24 h maternal deprivation (MD) at postnatal day (PND) 3 -on cognitive performance and hippocampal structure in 12-17-week-old female rats. Behavioral performance was examined in: the Elevated Plus Maze, as an index for general anxiety; the rodent Iowa gambling test, probing reward-based decision making; and the object recognition and object-in-location task, to assess non-stressful contextual memory performance. We further determined hippocampal dentate gyrus (DG) volume and cell density as well as adult proliferation and neurogenesis rates. Half of the rats was treated with the glucocorticoid receptor antagonist mifepristone during a critical pre-pubertal developmental window , in an attempt to ameliorate the potentially adverse behavioral consequences of ELS. Neither MD nor treatment with the glucocorticoid antagonist affected behavioral performance of the females in any of the tasks. Also, DG structure, proliferation and neurogenesis were not different between the groups. Lack of structural differences and a behavioral phenotype in non-stressful hippocampus dependent learning tasks fits with the lack of phenotype generally reported after ELS in female but less so in male rodents. As evident from an extensive literature review, female and male animals appear to respond more similarly to early-life adversity when tested in anxiety-related tasks. This agrees with recent findings in humans suggesting that females may be relatively resilient to the structural/hippocampal effects of childhood maltreatment, but not to the anxiety and mood-related psychopathology for which childhood maltreatment is considered a risk factor.

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“…Although adult neurogenesis appears to be necessary for the beneficial effects of some antidepressants, suppression of neurogenesis alone does not result in a depressive phenotype, suggesting that a reduction in newborn neurons is not sufficient to cause depression (Airan et al 2007;David et al 2009). Conversely, physical exercise can increase performance in many cognitive tasks and may also restore some degree of hippocampal function in psychiatric patients or in healthy but aging individuals by promoting adult neurogenesis (van Praag et al 1999a(van Praag et al ,b, 2005Creer et al 2010;Lugert et al 2010). …”

Section: Role Of Adult Neurogenesis In Mediating Antidepressant Actionmentioning

confidence: 99%

Adult Neurogenesis and Psychiatric Disorders

Kang

Wen

Song

et al. 2016

Cold Spring Harb Perspect Biol

148

114

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Psychiatric disorders continue to be among the most challenging disorders to diagnose and treat because there is no single genetic or anatomical locus that is causative for the disease. Current treatments are often blunt tools used to ameliorate the most severe symptoms, at the risk of disrupting functional neural systems. There is a critical need to develop new therapeutic strategies that can target circumscribed functional or anatomical domains of pathology. Adult hippocampal neurogenesis may be one such domain. Here, we review the evidence suggesting that adult hippocampal neurogenesis plays a role in emotional regulation and forms of learning and memory that include temporal and spatial memory encoding and context discrimination, and that its dysregulation is associated with psychiatric disorders, such as affective disorders, schizophrenia, and drug addiction. Further, adult neurogenesis has proven to be an effective model to investigate basic processes of neuronal development and converging evidence suggests that aberrant neural development may be an etiological factor, even in late-onset diseases. Constitutive neurogenesis in the hippocampus of the mature brain reflects large-scale plasticity unique to this region and could be a potential hub for modulation of a subset of cognitive and affective behaviors that are affected by multiple psychiatric disorders.

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Running enhances spatial pattern separation in mice

Cited by 449 publications

References 50 publications

A Comparative Study Evaluating the Impact of Physical Exercise on Disease Progression in a Mouse Model of Alzheimer’s Disease

A Comparative Study Evaluating the Impact of Physical Exercise on Disease Progression in a Mouse Model of Alzheimer’s Disease

Effects of early-life stress on cognitive function and hippocampal structure in female rodents

Adult Neurogenesis and Psychiatric Disorders

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