Running Elevates Plasma  -Endorphin Immunoreactivity and ACTH in Untrained Human Subjects

Gambert, Steven; Garthwaite, Thomas L.; Pontzer, Carol H.; Cook, Elizabeth E.; Tristani, Felix E.; Duthie, Edmund H.; Martinson, Donald R.; Hagen, Thad C.; McCarty, Daniel J.

doi:10.3181/00379727-168-41225

Cited by 81 publications

(27 citation statements)

References 3 publications

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“…Previous reports have shown that naloxone increases plasma ACTH at rest in man (VOLAVKA et al, 1979), and that sufficiently intense exercise enhances ACTH release (FRAIOLI et a!.,1980;GAMBERT et al,1981). The seemingly discordant result of the lack of naloxone effect on resting plasma ACTH might depend on the naloxone dosage.…”

Section: Discussionmentioning

confidence: 81%

“…The endogeneous opiate /3-endorphin (BEP) is released from the pituitary during acute dynamic exercise (FRAIOLI et al, 1980;GAMBERT et al, 1981). The physiological role of exercise-induced elevation of BEP plasma concentration remains unresolved.…”

mentioning

confidence: 99%

“…Naloxone enhances pulmonary ventilation at high work intensities (GROSSMAN et al, 1984), which conforms to the inhibitory effects of endogeneous opiates on ventilatory regulation demonstrated by POKORSKI and LAHIRI (1981) and by . Naloxone also enhances, by an as yet undetermined mechanism, exercise-induced release of a number of hormones and neuromodulators (FRAIOLI et al, 1980;GAMBERT et al, 1981;GROSSMAN et al, 1984). GROSSMAN et al (1984) and SURBEY el al.…”

mentioning

confidence: 99%

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Opioid involvement in the perception of pain due to endurance exercise in trained man.

Paulev¹,

Thorbøll²,

Nielsen³

et al. 1989

Jpn.J.Physiol

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The purpose of this study was to evaluate the role of endogenous opiates in modulating physical performance during dynamic exercise in conscious man. The plasma concentration of fl-endorphin (BEP) and of adrenocorticotropic hormone (ACTH) along with muscle pain (McGuill Pain Questionnaire) were assessed in 17 trained, male runners before and after running the longest possible distance within 12 min (i.e., the Cooper test). Each runner participated twice in the test (double-blind cross-over design), with a 1-week interval-with or without an injection of the opiate antagonist naloxone (0.8 mg i.v.). The average (SEM) distance reached was 3,198 (45) m in the naloxone test and 3,240 (38) m in the placebo test. The BEP increased significantly during the tests by a factor of 4.1 on naloxone and by 2.8 on placebo (from the normal resting averages of 1.7 and 2.1 pmol/l, respectively). The ACTH also increased significantly by a factor of 2.0 on naloxone and 2.5 on placebo (from the normal resting averages of l 9.3 and 16.8 pmol/l, respectively). There were no significant differences between the naloxone and the placebo test with respect to the increments of BEP or ACTH by exercise. However, the perception of muscle pain was enhanced with naloxone. The increased perception of pain did not decrease the athletes ability to perform in terms of the distance run. We conclude that endogenous opiates are involved in the perception of pain associated with exhaustive exercise and may subserve psychological rather than physiological functions during exercise.

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Section: Discussionmentioning

confidence: 81%

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confidence: 99%

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confidence: 99%

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Opioid involvement in the perception of pain due to endurance exercise in trained man.

Paulev¹,

Thorbøll²,

Nielsen³

et al. 1989

Jpn.J.Physiol

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“…In addition, exercise previously has been demonstrated to increase various EOP levels such as Methionine-enkephalin (Metenkephalin), Peptide F and -endorphin [4,5,9,11,12,15,19]. It has been suggested that training may also effect exercise responses of f-endorphin and Peptide F 3 --61 [4,19].…”

mentioning

confidence: 99%

“…Endogenous opioid peptides (EOP) appear to be involved with thermoregulation an adaptation to extremes in the thermal environment 12,14].…”

mentioning

confidence: 99%

Plasma opioid peptide responses during heat acclimation in humans

et al. 1987

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The hemorphins: A new class of opioid peptides derived from the blood protein hemoglobin

1997

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Running Elevates Plasma -Endorphin Immunoreactivity and ACTH in Untrained Human Subjects

Cited by 81 publications

References 3 publications

Opioid involvement in the perception of pain due to endurance exercise in trained man.

Opioid involvement in the perception of pain due to endurance exercise in trained man.

Plasma opioid peptide responses during heat acclimation in humans

The hemorphins: A new class of opioid peptides derived from the blood protein hemoglobin

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