Running decreases knee intra-articular cytokine and cartilage oligomeric matrix concentrations: a pilot study

Hyldahl, Robert D.; Evans, Alyssa; Kwon, Sunku; Ridge, Sarah T.; Robinson, Eric R.; Hopkins, J. Ty; Seeley, Matthew K.

doi:10.1007/s00421-016-3474-z

Cited by 49 publications

(41 citation statements)

References 38 publications

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“…They found no differences between groups in acute serum COMP concentrations in response to exercise or over time, after the aerobic and RE sessions . In contrast, Hyldahl et al . found an increase in COMP concentration in six healthy individuals after 30 min of running and also provided additional information suggesting that serum COMP following lower body exercise may largely be from the knee joint, since they found a significant inverse relation between synovial fluid and serum COMP concentrations after the exercise session .…”

Section: Discussionmentioning

confidence: 94%

“…In contrast, Hyldahl et al . found an increase in COMP concentration in six healthy individuals after 30 min of running and also provided additional information suggesting that serum COMP following lower body exercise may largely be from the knee joint, since they found a significant inverse relation between synovial fluid and serum COMP concentrations after the exercise session . In a study involving 45 male runners, Mündermann et al .…”

Section: Discussionmentioning

confidence: 96%

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Acute effect of a resistance exercise session on markers of cartilage breakdown and inflammation in women with rheumatoid arthritis

et al. 2017

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Women with and without RA have similar changes in response to a RE session in levels of inflammation biomarkers, but not of cartilage breakdown. IL-10 and IL-1ra increased after the RE session, indicating that RE may have an acute anti-inflammatory effect. Additional studies are necessary to clarify if repeated RE sessions can have long-term anti-inflammatory effects and the possible clinical repercussions of this cartilage breakdown characteristic in response to exercise in RA patients.

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Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 96%

Acute effect of a resistance exercise session on markers of cartilage breakdown and inflammation in women with rheumatoid arthritis

et al. 2017

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“…These results indicate that participants followed the instructions on maintaining consistent daily routines, and hence boundary conditions were comparable between test days (time of day, food intake, previous physical activity level, etc.). Comparisons of baseline concentrations to those reported in other studies are difficult because different assays were used 19,20,33 or results were reported in other units (e.g., units/liter 25e27,36 ) that cannot be converted because some assays target different components or fragments of COMP. Baseline sCOMP levels in our study were similar in men and in women.…”

Section: Discussionmentioning

confidence: 99%

Dose-response relationship between ambulatory load magnitude and load-induced changes in COMP in young healthy adults

Herger

Vach

Liphardt

et al. 2019

Osteoarthritis and Cartilage

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The results of this study provide important evidence of a dose-response relationship between ambulatory load magnitude and load-induced changes in sCOMP. Our data suggests that in normal weight persons sCOMP levels are more sensitive to increased than to reduced load. The experimental framework presented here may form the basis for studying the relevance of the dose-response relationship between ambulatory load magnitude and load-induced changes in biomarkers involved in metabolism of healthy articular cartilage and after injury.

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“…The net flow across the synovial interstitium can be enhanced during joint flexion due to an increased intra‐articular fluid pressure . Beyond that, Hyldahl et al showed that the decrease of COMP in synovial fluid measured in recreational runners 15 min after a running intervention correlated with the increase of serum COMP observed immediately after running and thus give first indications that elevated serum COMP levels after physical activity are in part the result of a better transport of COMP from the synovial fluid into the lymphatic system and bloodstream. Other possible sources of COMP should be also kept in mind.…”

Section: Discussionmentioning

confidence: 99%

Effect of increased mechanical knee joint loading during running on the serum concentration of cartilage oligomeric matrix protein (COMP)

Firner

Willwacher

Marées

et al. 2018

Journal Orthopaedic Research

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The purpose of the study was to investigate the effect of an increase in mechanical knee joint loading during running on the serum COMP level. On two different test days, 20 healthy men ran with knee orthoses for 30 min on a treadmill (v = 2.2 m/s). On day 1, the orthoses were passive, whereas on day 2 they were pneumatically driven (active) and thus increased the external knee flexion moments (+30.9 Nm) during stance phase. Lower-limb mechanics and serum COMP levels (baseline; 0, 0.5, 1, 2 h post running) were analyzed. COMP levels increased immediately after running with passive (+35%; pre: 7.5 U/l, 95%CI: 6.4, 8.7, post: 9.8 U/l, 95%CI: 8.8, 10.8, p < 0.001) and active orthoses (+45%; pre: 7.6 U/l; 95%CI: 6.4, 8.8, post: 10.3 U/l, 95%CI: 9.2, 11.5, p < 0.001), but they did not differ between interventions. While running with active orthoses, greater ankle dorsiflexion angles, knee flexion angles, and moments occurred (p < 0.05). Comparing both interventions, the Δ COMP pre-post, meaning the difference (Δ) between running with active and passive orthoses in pre to post COMP level change (=level after (post) running minus level before (pre) running), correlated negatively with Δ COMP baseline (difference between the baseline COMP level before running with active and passive orthoses, r = -0.616; p = 0.004), and with a positive tendence with the Δ maximum knee flexion (r = 0.388; p = 0.091). Therefore, changes in COMP concentration after physical activity seem to be highly influenced by the COMP baseline level. In addition, correlation analysis indicates that modifications in knee joint kinematics have a greater effect on cartilage metabolism than an increase in joint moments. © 2018 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 36:1937-1946, 2018.

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Running decreases knee intra-articular cytokine and cartilage oligomeric matrix concentrations: a pilot study

Abstract: Running appears to decrease knee intra-articular pro-inflammatory cytokine concentration and facilitates the movement of COMP from the joint space to the serum.

Cited by 49 publications

References 38 publications

Acute effect of a resistance exercise session on markers of cartilage breakdown and inflammation in women with rheumatoid arthritis

Acute effect of a resistance exercise session on markers of cartilage breakdown and inflammation in women with rheumatoid arthritis

Dose-response relationship between ambulatory load magnitude and load-induced changes in COMP in young healthy adults

Effect of increased mechanical knee joint loading during running on the serum concentration of cartilage oligomeric matrix protein (COMP)

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