Ruminococcaceae_UCG-013 Promotes Obesity Resistance in Mice

Feng, Jinlian; Ma, Hongan; Huang, Yi‐Ting; Li, Jiangchao; Li, Weidong

doi:10.3390/biomedicines10123272

Cited by 20 publications

(14 citation statements)

References 56 publications

(62 reference statements)

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“…Mueller et al [40] studied that after metformin treatment, the relative abundance of Ruminococcus torque group increased and improved overweight/obese adults, which means that Ruminococcus torques can alleviate obesity. Feng et al [41] also proved that Ruminococcaceae can alleviate obesity. Studies have shown that Ruminococcaceae_UCG-013 is positively correlated with serum HDL-C levels and negatively correlated with serum TC, TG and LDL-C levels, and can be identi ed as the most important biomarker for reducing obesity.…”

Section: Discussionmentioning

confidence: 97%

Exploring the causality between gut microbiota and esophageal carcinoma: a two-sample Mendelian randomization analysis

Lu,

Zuo,

Deng

et al. 2024

Preprint

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Background Esophageal cancer is a common tumor of upper gastrointestinal tract. However, the increasing evidence indicates that gut microbiota are closely related to the occurrence and development of esophageal cancer, the causal association between gut microbiota and esophageal cancer remains to be determined. As a consequence, in this paper, a two-sample Mendelian randomization analysis was used to evaluate and explore the causal relationship between gut microbiota and the risk of esophageal cancer, and identify specific pathogenic bacterial taxa. Methods Genetic instrumental variables for gut microbiota were identified from a genome-wide association study (GWAS) of 18,340 participants, esophageal cancer as the outcome variable was identified from a GWAS including 1091 cases and 410,350 controls. Using the inverse variance weighted (IVW) method as the primary analysis, and further (using) the weighted median method, MR-Egger regression, MR multi-directional residuals, and outlier tests were further performed to improve the robustness of the results. Results The IVW results showed that genus.DefluviitaleaceaeUCG011 (OR = 3.124, 95%CI 1.388–7.031, P = 0.006), genus.LachnospiraceaeUCG008 (OR = 3.964,95%CI 1.463–10.740, P = 0.007), family.Pasteurellaceae.id.3689(OR = 2.022, 95%CI 1.046 − 3.909, P = 0.036)and order.Pasteurellales.id.3688༈OR = 2.022, 95%CI1.046 − 3.909, P = 0.036༉showing a positive causal relationship between gut microbiota and esophageal cancer.Conversely,genus.Peptococcus(OR = 0.525, 95% CI 0.286–0.961,P = 0.037) ,genus.Ruminiclostridium5(OR = 0.117,95%CI0.0310.442,P = 0.002),genus.RuminococcaceaeUCG009 ༈OR = 0.350, 95%CI 0.157 − 0.777, P = 0.01༉and genus.Ruminococcus1༈OR = 0.341, 95%CI 0.118 − 0.985, P = 0.047༉showed a negative causal relationship with esophageal cancer. No significant heterogeneity was found in the instrumental variable or horizontal pleiotropy. Conclusions Our MR analysis study revealed that the gut microbiota was causally associated with esophageal cancer and the risk of esophageal cancer, and also identified eight bacterial taxa with a causal relationship with the development and progression of esophageal cancer.That may be useful in providing new insights for further mechanistic and clinical studies of microbiota-mediated cancer.

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Section: Discussionmentioning

confidence: 97%

Exploring the causality between gut microbiota and esophageal carcinoma: a two-sample Mendelian randomization analysis

Lu,

Zuo,

Deng

et al. 2024

Preprint

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“…The Genus Ruminococcaceae UCG003 belongs to the Ruminococcaceae family, and many bacteria in this family are known to be general butyrate-producing bacteria [44]. The effect of Ruminococcaceae UCG003 on IVDD may be mediated by butyrate, as shown by Jia et al [45].…”

Section: Discussionmentioning

confidence: 98%

Genetic analysis of the causal relationship between gut microbiota and intervertebral disc degeneration: a two-sample Mendelian randomized study

Zheng,

Wu,

et al. 2023

Eur Spine J

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Purpose Several recent studies have reported a possible association between gut microbiota and intervertebral disc degeneration; however, no studies have shown a causal relationship between gut microbiota and disc degeneration. This study was dedicated to investigate the causal relationship between the gut microbiota and intervertebral disc degeneration and the presence of potentially bacterial traits using two-sample Mendelian randomization. Methods A two-sample Mendelian randomization study was performed using the summary statistics of the gut microbiota from the largest available genome-wide association study meta-analysis conducted by the MiBioGen consortium. Summary statistics of intervertebral disc degeneration were obtained from the FinnGen consortium R8 release data. Five basic methods and MR-PRESSO were used to examine causal associations. The results of the study were used to examine the causal association between gut microbiota and intervertebral disc degeneration. Cochran's Q statistics were used to quantify the heterogeneity of instrumental variables. Results By using Mendelian randomization analysis, 10 bacterial traits potentially associated with intervertebral disc degeneration were identified: genus Eubacterium coprostanoligenes group, genus Lachnoclostridium, unknown genus id.2755, genus Marvinbryantia, genus Ruminococcaceae UCG003, family Rhodospirillaceae, unknown genus id.959, order Rhodospirillales, genus Lachnospiraceae NK4A136 grou, genus Eubacterium brachy group. Conclusion This Mendelian Randomization study found a causal effect between 10 gut microbiota and intervertebral disc degeneration, and we summarize the possible mechanisms of action in the context of existing studies. However, additional research is essential to fully understand the contribution of genetic factors to the dynamics of gut microbiota and its impact on disc degeneration.

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“…These bacteria are able to utilize cellulose and other components of plant cell walls to produce organic acids and gases through fermentation, providing energy and nutrients to the host. These bacteria in the human gut are associated with intestinal health and metabolism ( 31 ).…”

Section: Discussionmentioning

confidence: 99%

Causal associations between gut microbiota and Cholestatic liver diseases: a Mendelian randomization study

Yang,

Ma,

Wang

et al. 2024

Front. Med.

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BackgroundThe etiological factors of Cholestatic Liver Diseases especially primary sclerosing cholangitis (PSC) and primary biliary cholangitis (PBC) are not fully illustrated. It has been reported in previous observational studies that gut microbiota are associated with cholestatic liver diseases. However, there is uncertainty regarding the causality of this association. By using Mendelian randomization, this study aimed to examine the causal impact of gut microbiota on cholestatic liver diseases.MethodsFrom large-scale genome-wide association studies, genetic instruments for each gut microbiota taxa as well as primary biliary cholangitis and primary sclerosing cholangitis were developed. Subsequently, we conducted a two-sample Mendelian randomization analysis, supplemented by multiple post hoc sensitivity analyses. Additionally, we performed reverse MR analyses to investigate the possibility of the reverse causal association.ResultThis two-sample MR study indicated that the order Bacillales, family Peptostreptococcaceae, family Ruminococcaceae, genus Anaerotruncu was associated with a decreased risk of developing PBC, and that order Selenomonadales, family Bifidobacteriaceae may be factors that increase the risk of PBC. On the other hand, we also identified order Selenomonadales, family Rhodospirillaceae, and genus RuminococcaceaeUCG013 were positively associated with PSC. The order Actinomycetales, family Actinomycetaceae, genus Actinomyces, genus Alloprevotella, genus Barnesiella, and genus Peptococcus were found negative associations with the risk of PSC. The reverse MR analysis demonstrated no statistically significant relationship between PBC, PSC and these specific gut microbial taxa.ConclusionOur findings offered novel evidence that the abundance of particular bacteria contributes to the risk of PBC and PSC, which may contribute to more effective approaches to PBC and PSC therapy and prevention.

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Ruminococcaceae_UCG-013 Promotes Obesity Resistance in Mice

Cited by 20 publications

References 56 publications

Exploring the causality between gut microbiota and esophageal carcinoma: a two-sample Mendelian randomization analysis

Exploring the causality between gut microbiota and esophageal carcinoma: a two-sample Mendelian randomization analysis

Genetic analysis of the causal relationship between gut microbiota and intervertebral disc degeneration: a two-sample Mendelian randomized study

Causal associations between gut microbiota and Cholestatic liver diseases: a Mendelian randomization study

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