Rumination and the default mode network: Meta-analysis of brain imaging studies and implications for depression

Zhou, Huixia; Chen, Xiao; Shen, Yangqian; Li, Le; Chen, Ning-Xuan; Zhu, Zhili; Castellanos, F. Xavier; Chen, Yan

doi:10.1016/j.neuroimage.2019.116287

Cited by 360 publications

(276 citation statements)

References 76 publications

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“…Our finding that FCs within DMN were decreased during rumination may seem counter-intuitive, but finer subsystem level analysis indicates this decrease may be driven by a dissociated FC pattern among 9 different subsystems. Task based studies on rumination convergently found increased activity in the core subsystem as compared to distraction, but evidence regarding the other two subsystems has been less consistent (38). Previous rumination state studies indicated FCs between core subsystem region (PCC) and rest DMN regions may best differentiate rumination state and resting state (28).…”

Section: Discussionmentioning

confidence: 93%

“…Indeed, convergent lines of evidence suggest the DMN may be the key brain network supporting rumination (6). Using typical task-based designs, researchers found DMN region activities were higher in rumination compared to distraction, which is a control condition requiring participants to focus on externally oriented thoughts that are unrelated to themselves (7)(8)(9)(10)(11).…”

Section: Introductionmentioning

confidence: 99%

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The Subsystem Mechanism of Default Mode Network Underlying Rumination: a Reproducible Neuroimaging Study

Chen

Shen

et al. 2019

Preprint

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Rumination is a specific form of self-generated thoughts and posited to be the psychological expression of abnormalities in the default mode network (DMN) in patients with major depressive disorder (MDD). Although converging lines of evidence link the neural basis of MDD and the DMN, the mechanisms through which DMN regions cooperatively underlie rumination remain largely unclear. Here, with a modified continuous state-like paradigm, we induce healthy participants to ruminate or imagine objective scenarios (as a distraction control condition) on 3 different MRI scanners. We compared functional connectivities (FC) and inter-subject correlations (ISC) of the DMN and its 3 functionally-defined subsystems between rumination and distraction states. Results yielded a highly reproducible and dissociated pattern. During rumination, within-DMN FC was generally decreased compared to the distraction state. At the subsystem level, we found increased FC between the core and medial temporal lobe (MTL) subsystem and decreased FC between the core and dorsal medial prefrontal cortex (DMPFC) subsystem and within the MTL subsystem. Furthermore, we found decreased ISC within the MTL subsystem. These results suggest that DMN regions interacted with each other differently and are activated less synchronously across subjects during rumination and shed new light on the association between rumination and MDD patients' DMN abnormalities. KEYWORDS: functional MRI, major depressive disorder, self-generated thought 3 SIGNIFICANCE STATEMENTRumination is widely accepted as the psychological expression of default mode network (DMN) alterations in patients with major depressive disorder (MDD), but our understanding of the DMN's mechanistic involvement remains rudimentary. Here, with a repeated measure continuous paradigm, we systematically examined how DMN subsystems underlie rumination. We found distinct patterns of functional connectivity within subject and less synchronized neural activities across subjects in DMN during rumination. These findings can help illuminate the association between rumination and DMN alterations in MDD. Confidence in our hypothesis-driven results is enhanced by their high reproducibility across three different scanners.

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Section: Discussionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

The Subsystem Mechanism of Default Mode Network Underlying Rumination: a Reproducible Neuroimaging Study

Chen

Shen

et al. 2019

Preprint

Self Cite

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“…Dysfunction of this region is known to play a role in depression and is related to amygdalar hyperactivation in response to negative stimuli in humans [66][67][68]. Besides its inhibitory tone on the amygdala, it also works as a hub within the default mode network (DMN), which is also found to be deregulated in depression [69,70] (see the section on human studies below).…”

Section: Animal Studiesmentioning

confidence: 99%

“…In contrast, psilocybin promotes the post-acute strengthening of DMN [88]. Functional connectivity within DMN and activity of its constituents have been independently found to be altered in patients with depression and associated with self-centered negative rumination [69,70]. Carhart-Harris et al [88] hypothesized that disruption of DMN by psychedelics facilitates remodeling of the connections responsible for negative rumination.…”

Section: Human Studiesmentioning

confidence: 99%

Natural Psychoplastogens As Antidepressant Agents

Vrankova

2020

Molecules

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Increasing prevalence and burden of major depressive disorder presents an unavoidable problem for psychiatry. Existing antidepressants exert their effect only after several weeks of continuous treatment. In addition, their serious side effects and ineffectiveness in one-third of patients call for urgent action. Recent advances have given rise to the concept of psychoplastogens. These compounds are capable of fast structural and functional rearrangement of neural networks by targeting mechanisms previously implicated in the development of depression. Furthermore, evidence shows that they exert a potent acute and long-term positive effects, reaching beyond the treatment of psychiatric diseases. Several of them are naturally occurring compounds, such as psilocybin, N,N-dimethyltryptamine, and 7,8-dihydroxyflavone. Their pharmacology and effects in animal and human studies were discussed in this article.

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“…Rumination, though not a defining symptom of depression, is commonly associated with major depression and is indicative of depression onset, its severity, and duration of symptoms [42]. The DMN is the primary neural facilitator of the ruminating process, specifically in the dorsomedial PFC [43]. Early-onset cannabinoid use has been associated with hyperconnectivity within the DMN [44].…”

Section: Ruminationmentioning

confidence: 99%

Depression Onset in Long-term Adolescent Cannabinoid Use: A Neurobiological Review

Forrester

Jahan

2020

Cureus

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Escalating cannabis use may be linked to decreased motivation and anhedonia, which are symptoms of depression. Adolescent cannabis users with subthreshold depressive symptoms such as reduced motivation may be susceptible to the development of significant anhedonia in addition to impaired emotional development. The main issue regarding depression within the context of cannabis use is whether or not there is a neurobiological basis linking the two variables.A Medical Subject Headings (MeSH) function PubMed search using the keywords "cannabis, depression, adolescence, endocannabinoid, and temperament" returned 1,109 articles. Data were included from studies that satisfied the following criteria: (i) published within the last 10 years (older studies were included based on relevance), (ii) on adolescent subjects (animal or human), (iii) published in English, (iv) journal articles, systematic reviews, meta-analyses, clinical trials, observational studies (animal or human), (v) on subjects who had unipolar depression with no comorbidities, and (vi) on subjects who used cannabis [with no confounding variables such as the use of ethanol, nicotine, cocaine, lysergic acid diethylamide (LSD), and heroin; and no medical conditions such as comorbid psychosis, mania, or autism].Depressive symptoms in cannabinoid users were a common co-occurrence partly explained by pleiotropic linkage of genetic locus identified on chromosome 11q23.1-q23.2 and comprises the gene sequence nuclear cell adhesion molecule 1-tetratricopeptide repeat domain 12ankyrin repeat and kinase domain containing 1-dopamine receptor D2 (NCAM1-TTC12-ANKK1-DRD2). The relationship between the two is not invariant and is influenced by polymorphic DRD, endocannabinoid receptor (CNR), and 5-HT genes. Anhedonia seemed to be the most important symptom. Cannabinoid-induced long-term neuroplastic changes, particularly in the dorsal striatum, is a possible mechanism resulting in anhedonia and longterm effects on motivation.

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Rumination and the default mode network: Meta-analysis of brain imaging studies and implications for depression

Cited by 360 publications

References 76 publications

The Subsystem Mechanism of Default Mode Network Underlying Rumination: a Reproducible Neuroimaging Study

The Subsystem Mechanism of Default Mode Network Underlying Rumination: a Reproducible Neuroimaging Study

Natural Psychoplastogens As Antidepressant Agents

Depression Onset in Long-term Adolescent Cannabinoid Use: A Neurobiological Review

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