Rumen transfaunation

DePeters, E.J.; George, Lisle W.

doi:10.1016/j.imlet.2014.05.009

Cited by 94 publications

(88 citation statements)

References 49 publications

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“…9 Anecdotal reports of the use of parental feces to treat antibiotic-associated diarrhea in children had existed, but these cases were largely unknown until the publication of the first case series in 1958 of four patients with pseudomembranous enterocolitis by the American surgeon, Ben Eiseman. 10 For years, FMT remained a rarely used, if not forgotten, therapy.…”

Section: History Of Fmtmentioning

confidence: 99%

Update on Fecal Microbiota Transplantation 2015: Indications, Methodologies, Mechanisms, and Outlook

et al. 2015

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The community of microorganisms within the human gut (or microbiota) is critical to health and functions with a level of complexity comparable to an organ system. Alterations of this ecology (or dysbiosis) has been implicated in a number of disease states, the prototypical example being Clostridium difficile infection (CDI). Fecal microbiota transplantation (FMT) has been demonstrated to durably alter the gut microbiota of the recipient and has shown efficacy in the treatment of recurrent CDI. There is hope that FMT may eventually prove beneficial for treatment of other disease associated with alterations in gut microbiota, such as inflammatory bowel disease, irritable bowel syndrome and the metabolic syndrome, to name a few. Although the basic principles that underlie the mechanisms by which FMT demonstrates therapeutic efficacy in CDI are becoming apparent, further research is needed to understand the possible role of FMT in these other conditions. Though relatively simple to perform, questions regarding both short- and long-term safety, as well as the complex and rapidly evolving regulatory landscape has limited widespread utilization. Future work will focus on establishing best practices and more robust safety data than exist currently, as well as refining FMT beyond current “whole stool” transplants to increase safety and tolerability. Encapsulated formulations, full spectrum stool-based products and defined microbial consortia are all in the immediate future.

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Section: History Of Fmtmentioning

confidence: 99%

Update on Fecal Microbiota Transplantation 2015: Indications, Methodologies, Mechanisms, and Outlook

et al. 2015

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“…Transplantation of rumen contents has been successfully used to clinically treat indigestion and return the rumen to its normal function, and to convert toxic compounds found in some plants to harmless or even beneficial compounds 20 . The exchange of ruminal contents from non-fasted to fasted lambs has also been suggested to accelerate repletion of the protozoal population after re-alimentation 21 .…”

Section: Discussionmentioning

confidence: 99%

Repeated inoculation of cattle rumen with bison rumen contents alters the rumen microbiome and improves nitrogen digestibility in cattle

Ribeiro

Oss

et al. 2017

Sci Rep

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Future growth in demand for meat and milk, and the socioeconomic and environmental challenges that farmers face, represent a “grand challenge for humanity”. Improving the digestibility of crop residues such as straw could enhance the sustainability of ruminant production systems. Here, we investigated if transfer of rumen contents from bison to cattle could alter the rumen microbiome and enhance total tract digestibility of a barley straw-based diet. Beef heifers were adapted to the diet for 28 days prior to the experiment. After 46 days, ~70 percent of rumen contents were removed from each heifer and replaced with mixed rumen contents collected immediately after slaughter from 32 bison. This procedure was repeated 14 days later. Intake, chewing activity, total tract digestibility, ruminal passage rate, ruminal fermentation, and the bacterial and protozoal communities were examined before the first and after the second transfer. Overall, inoculation with bison rumen contents successfully altered the cattle rumen microbiome and metabolism, and increased protein digestibility and nitrogen retention, but did not alter fiber digestibility.

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“…The process involves transfer of cud (partially digested food from the first stomach) of a healthy donor animal to treat indigestion in a sick recipient animal. 74 In modern medicine, the first published research on the concept of FMT was by Eiseman et al 75 in 1958 and involved fecal enemas as an adjunctive treatment for antibiotic-induced pseudomembranous colitis. However, between 1958 and 2010, almost no reports have been published on this technique in the medical literature.…”

Section: Fecal Microbiota Transplantmentioning

confidence: 99%

Clostridium difficile Infection and Fecal Microbiota Transplant

Liubakka

Vaughn

2016

AACN Advanced Critical Care

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Clostridium difficile infection (CDI) is a major source of morbidity and mortality for hospitalized patients. Although most patients have a clinical response to existing antimicrobial therapies, recurrent infection develops in up to 30% of patients. Fecal microbiota transplant is a novel approach to this complex problem, with an efficacy rate of nearly 90% in the setting of multiple recurrent CDI. This review covers the current epidemiology of CDI (including toxigenic and nontoxigenic strains, risk factors for infection, and recurrent infection), methods of diagnosis, existing first-line therapies in CDI, the role of fecal microbiota transplant for multiple recurrent CDIs, and the potential use of fecal microbial transplant for patients with severe or refractory infection.

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Rumen transfaunation

Cited by 94 publications

References 49 publications

Update on Fecal Microbiota Transplantation 2015: Indications, Methodologies, Mechanisms, and Outlook

Update on Fecal Microbiota Transplantation 2015: Indications, Methodologies, Mechanisms, and Outlook

Repeated inoculation of cattle rumen with bison rumen contents alters the rumen microbiome and improves nitrogen digestibility in cattle

Clostridium difficile Infection and Fecal Microbiota Transplant

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