[RuII(hedta)]− complexes of 2,2′-dipyridylamine (dpaH) and a bifunctional tethered analog, N,N,N′,N′-tetrakis(2-pyridyl)adipamide (tpada)

Bridging ligands comprising two or more di-2-pyridylmethyl or amine arms: Alternatives to 2,2′-bipyridyl-containing bridging ligands

“…Potential ligands possessing two di-2-pyridylamine subunits separated by aliphatic spacers have been reported (Table 5 Tertiary amide derivatives containing two di-2-pyridylamino chelating groups have also been studied in respect of their coordination chemistry [89] and for preparing delivery agents which can carry the {Ru(NO)} chromophore ("caged NO") as potential therapeutics for vasodilation and photodynamic therapy of tumours. (where hfa is hexafluoroacetoacetate), was prepared in good 70% yield (Scheme 11).…”

Interaction studies between a 1,10-phenanthroline adduct of palladium(II) dithiocarbamate anti-tumor complex and calf thymus DNA. A synthesis spectral and in-vitro study

“…Many studies focus on the transition metal complexes with heterocyclic ligands such as 2, 2 -bipyridine (bpy), 2,2 -bipyridylamine (bpa) and 1,10-phenanthroline (phen) [5][6][7]. As a result of rotational flexibility around carbon-carbon single bond bridging the two pyridine rings of bpy, as well as central amine bridging the two pyridine rings of bpa, the two pyridine planes adopt either coplanar or tilted conformation in the coordination to the metal centers [8,9]. However, such a rotational flexibility is not possible in phen and it remains coplanar even after coordination.…”

Non-covalent DNA binding and cytotoxicity of certain mixed-ligand ruthenium(ii) complexes of 2,2′-dipyridylamine and diimines

“…The rationale behind the design of the complexes is that the bidentate primary ligand Hdpa offers flexibility around the secondary amine nitrogen bridging the two pyridine rings, the two pyridine planes adopting either coplanar or tilted conformation upon coordination to metal centers. 20 Also, Hdpa possesses the potential to form hydrogen bond with suitable DNA functionalities, which would be expected to enhance the DNA binding affinity significantly. The co-ligands phen and extended 1,10-phenanthrolines with different numbers of aromatic rings to vary the surface area for intercalation would be expected to act as affinity ligands, and dictate the extent of DNA binding interaction of the complexes.…”