Rücktitelbild: Novel Strategy to Drive the Intracellular Uptake of Lipid Nanoparticles for Photodynamic Therapy (Angew. Chem. 16/2023)

Abstract

The superiore fficacy … …ofaminopolycarboxylic acid conjugated lipid nanoparticles over standard liposomal nanoparticles is described by Juan Chen, Gang Zheng et al. in their Research Article (e202218218). EDTA-lipid based nanoparticles fluidize the cell membrane in a detergent-like manner and improve delivery to the cell by 25-fold. This novel nanoparticle design feature can be deployed across lipid nanoparticles to accelerate cancer nanomedicine drug delivery.