Rubus Occidentalis and its bioactive compounds against cancer: From molecular mechanisms to translational advances

Wang, Guanru; Su, Hengpei; Guo, Zijian; Li, Honglin; Jiang, Zhishen; Cao, Yubin; Li, Chunjie

doi:10.1016/j.phymed.2023.155029

Cited by 3 publications

(1 citation statement)

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“…Angiogenesis mainly encompasses degrading the vascular basement membrane, proliferating and migrating vascular endothelial cells, and forming new vessels [ 46 ], which involves multiple regulatory molecules, for instance, fibroblast growth factor (FGF), VEGF, and interleukin‐8 (IL‐8) [ 47 ]. Numerous studies found that the upgraded glycolysis of tumor cells activated the expression of angiogenesis‐associated proteins, which in turn transported more nutrients for tumor cells to promote cell growth and tumor metastasis [ 48 , 49 , 50 ].…”

Section: The Regulatory Role Of Glycolysis In Tumor Developmentmentioning

confidence: 99%

The regulatory roles and clinical significance of glycolysis in tumor

Qiao,

Hu,

Wang

2024

Cancer Communications

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Metabolic reprogramming has been demonstrated to have a significant impact on the biological behaviors of tumor cells, among which glycolysis is an important form. Recent research has revealed that the heightened glycolysis levels, the abnormal expression of glycolytic enzymes, and the accumulation of glycolytic products could regulate the growth, proliferation, invasion, and metastasis of tumor cells and provide a favorable microenvironment for tumor development and progression. Based on the distinctive glycolytic characteristics of tumor cells, novel imaging tests have been developed to evaluate tumor proliferation and metastasis. In addition, glycolytic enzymes have been found to serve as promising biomarkers in tumor, which could provide assistance in the early diagnosis and prognostic assessment of tumor patients. Numerous glycolytic enzymes have been identified as potential therapeutic targets for tumor treatment, and various small molecule inhibitors targeting glycolytic enzymes have been developed to inhibit tumor development and some of them are already applied in the clinic. In this review, we systematically summarized recent advances of the regulatory roles of glycolysis in tumor progression and highlighted the potential clinical significance of glycolytic enzymes and products as novel biomarkers and therapeutic targets in tumor treatment.

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Section: The Regulatory Role Of Glycolysis In Tumor Developmentmentioning

confidence: 99%

The regulatory roles and clinical significance of glycolysis in tumor

Qiao,

Hu,

Wang

2024

Cancer Communications

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Updated evidence on raspberries as functional foods: Anticancer bioactivity and therapeutic implications

Azzini,

Barnaba,

Mattera

et al. 2024

Food Frontiers

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Raspberries (RBs) (Rubus idaeus) are rich in bioactive compounds with promising anticancer properties. This review provides a comprehensive analysis of the anticancer effects of RBs, highlighting their potential as natural agents in cancer prevention and therapy. Bioactive compounds in RBs induce apoptosis, arrest the cell cycle, inhibit angiogenesis, and suppress metastasis. Preclinical studies demonstrate significant anticancer effects against colon, breast, lung, prostate, and cervical cancers, with clinical studies also supporting their therapeutic potential. Although preclinical findings are encouraging, further large‐scale clinical trials are needed to confirm their efficacy and safety in humans. Optimizing formulations to enhance bioavailability and therapeutic effectiveness is crucial. This review emphasizes the potential of dietary interventions involving RBs as a complementary approach to conventional cancer therapies, paving the way for future research and clinical innovations.

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