Rubulavirus: Mumps Virus

Knowles, Wendy A.

doi:10.1002/9780470688618.taw0241

Cited by 4 publications

(5 citation statements)

References 222 publications

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“…Greatest heterogeneity was 15.6% with genotype A (Technical Appendix Figure 2). A similar pattern was observed by additional phylogenetic analysis with the HN gene (Figure 1), recommended by the World Health Organization ( 8 ). These analyses confirmed that all viruses had genotype K.…”

Section: The Studysupporting

confidence: 81%

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Importation of Mumps Virus Genotype K to China from Vietnam

Liu¹,

Deng²,

Lin³

et al. 2018

Emerg. Infect. Dis.

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Section: The Studysupporting

confidence: 81%

“…The disease is highly contagious and shows nonspecific symptoms (e.g., headache and fever). However, in some cases complications, such as aseptic meningitis, orchitis, encephalitis, and deafness, might occur ( 1 ). …”

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Importation of Mumps Virus Genotype K to China from Vietnam

Liu¹,

Deng²,

Lin³

et al. 2018

Emerg. Infect. Dis.

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“…The first description of a mild epidemic illness with swelling near the ears, and occasionally with painful swelling of one or both testes, is accredited to Hippocrates in the 5 th century BC. The name mumps may be derived from the old English verb meaning “to sulk” or from the Scottish verb meaning “to speak indistinctly” . In 1934, Johnson and Goodpasture demonstrated that mumps was caused by a virus present in saliva of infected patients .…”

Section: General Introduction Of Mumps and Mumps Virusmentioning

confidence: 99%

Genomic diversity of mumps virus and global distribution of the 12 genotypes

et al. 2014

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The WHO recently proposed an updated nomenclature for mumps virus (MuV). WHO currently recognizes 12 genotypes of MuV, assigned letters from A to N (excluding E and M), which are based on the nucleotide sequences of small hydrophobic (SH) and haemagglutinin-neuraminidase (HN) genes. A total of 66 MuV genomes are available in GenBank, representing eight of the 12 genotypes. To complete this dataset, whole genomes of seven isolates representing six genotypes (D, H, I, J, K and L) and one unclassified strain were sequenced. SH and HN genes of other representative strains were also sequenced. The degree of genetic divergence, predicted amino acid substitutions in the HN and fusion (F) proteins and geographic distributions of MuV strains were analysed based on the updated dataset. Nucleotide heterogeneity between genotypes reached 20% within the SH gene, with a maximum of 9% within the HN gene. The geographic and chronologic distributions of the 12 genotypes were summarised. This review contributes to our understanding of strain diversity for wild type MuV, and the results support the current WHO nomenclature.

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“…Swelling of the parotid gland(s) is the most common clinical presentation in symptomatic cases. Generally, the disease is mild, but complications such as orchitis, encephalitis, and deafness can occur (1). Following the introduction of the measles, mumps, and rubella vaccine (MMR), the reported incidence of mumps declined from Ͼ100 cases per 100,000 population on average before 1967 (prevaccine era) to 10 cases per 100,000 population in 1977 (2).…”

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Comparison of the Sensitivity of Laboratory Diagnostic Methods from a Well-Characterized Outbreak of Mumps in New York City in 2009

Rota

Rosen

Doll

et al. 2013

Clin. Vaccine Immunol.

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A mumps outbreak in upstate New York in 2009 at a summer camp for Orthodox Jewish boys spread into Orthodox Jewish communities in the Northeast, including New York City. The availability of epidemiologic information, including vaccination records and parotitis onset dates, allowed an enhanced analysis of laboratory methods for mumps testing. Serum and buccal swab samples were collected from 296 confirmed cases with onsets from September through December 2009. All samples were tested using the Centers for Disease Control and Prevention (CDC) capture IgM enzyme immunoassay (EIA) and a real-time reverse transcription-PCR (rRT-PCR) that targets the short hydrophobic gene. A subset of the samples (n ‫؍‬ 205) was used to evaluate 3 commercial mumps IgM assays and to assess the sensitivity of using an alternative target gene (nucleoprotein) in the rRT-PCR protocol. Among 115 cases of mumps with 2 documented doses of measles, mumps, and rubella (MMR) vaccine, the CDC capture IgM EIA detected IgM in 51% of serum samples compared to 9% to 24% using three commercial IgM assays. The rRT-PCR that targeted the nucleoprotein gene increased RNA detection by 14% compared to that obtained with the original protocol. The ability to detect IgM improved when serum was collected 3 days or more after symptom onset, whereas sensitivity of RNA detection by rRT-PCR declined when buccal swabs were collected later than 2 days after onset. Selection of testing methods and timing of sample collection are important factors in the ability to confirm infection among vaccinated persons. These results reinforce the need to use virus detection assays in addition to serologic tests.

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Rubulavirus: Mumps Virus

Cited by 4 publications

References 222 publications

Importation of Mumps Virus Genotype K to China from Vietnam

Importation of Mumps Virus Genotype K to China from Vietnam

Genomic diversity of mumps virus and global distribution of the 12 genotypes

Comparison of the Sensitivity of Laboratory Diagnostic Methods from a Well-Characterized Outbreak of Mumps in New York City in 2009

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