Rubomycin Loaded Erythrocytes in the Treatment of Mouse Tumor P388

Ataullakhanov, Fazoil I.; Vitvitsky, Victor; Kovaleva, V. L.; Mironova, Svetlana B.

doi:10.1007/978-1-4615-3030-5_26

Cited by 5 publications

(1 citation statement)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Intact RBCs can naturally bind anthracycline antibiotics in isotonic media ( Kravtzoff et al, 1990 ; Ataullakhanov et al, 1992 ). Despite that, this binding is weak, so anthracycline antibiotics need to be immobilized by the use of glutaraldehyde ( Ataullakhanov et al, 1994 ; Skorokhod et al, 2004 ).…”

Section: How We Can Take Advantage In Converting Rbcs Into a Drug Car...mentioning

confidence: 99%

Drug transport by red blood cells

Biagiotti,

Perla,

Magnani

2023

Front. Physiol.

View full text Add to dashboard Cite

This review focuses on the role of human red blood cells (RBCs) as drug carriers. First, a general introduction about RBC physiology is provided, followed by the presentation of several cases in which RBCs act as natural carriers of drugs. This is due to the presence of several binding sites within the same RBCs and is regulated by the diffusion of selected compounds through the RBC membrane and by the presence of influx and efflux transporters. The balance between the influx/efflux and the affinity for these binding sites will finally affect drug partitioning. Thereafter, a brief mention of the pharmacokinetic profile of drugs with such a partitioning is given. Finally, some examples in which these natural features of human RBCs can be further exploited to engineer RBCs by the encapsulation of drugs, metabolites, or target proteins are reported. For instance, metabolic pathways can be powered by increasing key metabolites (i.e., 2,3-bisphosphoglycerate) that affect oxygen release potentially useful in transfusion medicine. On the other hand, the RBC pre-loading of recombinant immunophilins permits increasing the binding and transport of immunosuppressive drugs. In conclusion, RBCs are natural carriers for different kinds of metabolites and several drugs. However, they can be opportunely further modified to optimize and improve their ability to perform as drug vehicles.

show abstract

Section: How We Can Take Advantage In Converting Rbcs Into a Drug Car...mentioning

confidence: 99%