Rubidium doped nano-hydroxyapatite with cytocompatibility and antibacterial

Liu, Yanjun; Tan, Yan; Wu, Jiangsong

doi:10.1080/21870764.2020.1865861

Cited by 15 publications

(9 citation statements)

References 41 publications

(43 reference statements)

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“…For both cases, our material meets the mechanical properties of the implant. Hence, Rb-doped HAp nanomaterials can be employed as a reliable antibacterial implant or replace the defective teeth and bone structures as reported in the literature [1,11,12,15].…”

Section: Resultsmentioning

confidence: 99%

“…With the rise in skeletal injuries and teeth implantation due to the increasing number of accidents and trauma cases, there is a dire need to develop biocompatible, bioactive, safe, and osteoconductive biomaterial that can fill the bone defects or replace the broken skeletal part within the body [1]. With the rapid advancement in nanoscience and nanobiotechnology, synthetic polymeric materials (e.g., polyethylene, polyurethane foam & polylactic acid) are commonly used as medical implants instead of expensive metal-based implant materials their biological stability.…”

Section: Introductionmentioning

confidence: 99%

“…Their results also showed enhanced bioactivity and biocompatibility of Rb-doped HAp (Rb-HAp), thus making it a suitable candidate for biomedical applications. In-vitro studies of Rb-HAp showed a better proliferation and differentiation of MG-63 cells and showed bacterial inhibition towards E.Coli and S. Aureus (ATCC 8739, ATCC 6538) [18].…”

Section: Introductionmentioning

confidence: 99%

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Synthesis of Rubidium-doped Calcium Hydroxyapatite Nanoparticles for Biomedical Applications

et al. 2021

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Due to high biocompatibility, bioactivity, and natural occurrence in bones and teeth, synthetic calcium hydroxyapatite (CaHAp) is a widely applied biomaterial in tissue engineering, including orthopedic surgery and dentistry. However, the brittle nature and low strength reduce its durability, which can be improved by doping metal ions. Rubidium (Rb) is an essential trace element that works as an antibacterial agent in the human body; therefore, it can be doped in synthetic Ca-HAp to promote its durability. In this work, Rb-doped calcium hydroxyapatite (Rb-HAp) nanoparticles are synthesized by the coprecipitation method at low temperatures. Phase purity, crystallinity, doping level, and mechanical properties are investigated by X-ray diffraction (XRD), inductively coupled plasma optical emission spectroscopy (ICP-OES), and micro-hardness tester. It is observed that a minute quantity (≈ 0.02%) of Rb remained in the apatite structure when 5% of Rb+ is doped via in situ method. Moreover, small dopant concentration did not affect the crystal structure and the tensile strength of HAp.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Synthesis of Rubidium-doped Calcium Hydroxyapatite Nanoparticles for Biomedical Applications

et al. 2021

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“…We considered the surgery day as day zero and the day after the operation (the rst day) based on the grouping of nanohydroxy gel and no additional dressing was used. (32,33) Seven and 14 days after wound induction and the treatment, we killed the animals and prepared a biopsy of their wound.…”

Section: Animal Studymentioning

confidence: 99%

“…(31). Also, in some new studies hydroxyapatite doped with ions for example, porous copper-and lithium-doped nanohydroxyapatite (32), Rubidium (33), magnesium and Nickle (34), and all these was used for evaluating cytocompatibility and its antibacterial effect. They show that by using this combination in animal and human wounds rehabilitation was signi cantly accelerated.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the effectiveness of nano-hydroxyapatite particles in wound healing in an animal study

Lalehzar

Meamar

Talebi

et al. 2022

Preprint

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Background The main activity of the skin is to create a protective barrier against damage. Loss of the skin due to injury or disease and failure to regenerate the affected area may result in disability, infection, or even death. We conducted the animal study to Evaluation of the effectiveness of nano-hydroxyapatite particles in wound healing. Method This animal study performed in Isfahan university of medical science animal lab. Experiments were performed on 30 Wistar in 5 groups. Biopsies 5×5mm were obtain of abdominal, and were transferred to the cell culture laboratory into the phosphate buffer saline (PBS). The cell proliferation was determined using the colorimetric MTS assay. The type and approach of this animal study is to create a deep skin wound and try to treat the wound with drug (nano_ hydroxyapatite 10%, nano_hydroxyapatite40%, combination of Nickle ion with nanohydroxyapatite 10%, and 40%) intervention on an animal model of rat. Macroscopic evaluation and pathological examination were done. For pathological and histological examination of the wound, sampling was done on the seventh and fourteenth days after ulcer induction. All continuous and categorical data are presented as mean ± standard deviation (SD) and frequency (percentage), respectively. Paired sample T-test and repeated measure analysis of variance (ANOVA), Chi-squared test was used. Results During this study, MTS assay was carried out to evaluate the proliferation of mice fibroblast on the gelatin without hydroxyapatite, and with 10, 40% hydroxyapatite after1, 2 and 3 days of culture. significant enhancement of cell proliferation was observed in nano HA 10, 40% and nano HA 10% with nickel in comparison when the cells seeded on gelatin and HA 10%. The best result was shown in 24 hours after seeding the cells in gelatin in comparison with 48, and 72 hours. Indeed, after 48 and 72 hours, the cell proliferation on gelatin decreased. In evaluation of Wound area with image j soft ward, the wound area between day 3,7 and 14 of treatment after wound induction there were no significant difference between groups. In microscopic study and analysis for evaluation and comparing wound length with the Michrome camera and Mosaic soft ward, there were no significant relation in time (p1 = 0.77). There is a difference is close to significant between the groups(p2 = 0.065). There was no significant difference between time and group(p3 = 0.323). In day 14 the wound length between groups had significant difference(p4 = 0.049). Conclusion In conclusion, hydroxyapatites and its combination with Nickle ion have significant effect on wound healing and cell proliferation.

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Rb‐Promoted Au/CeO₂ Nanocatalyst for Remarkably‐Enhanced Aniline Conversion to Azoxybenzene with Ultrahigh Selectivity

Khan,

Ju,

Han

et al. 2024

ChemCatChem

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Aromatic azo compounds have proven to be a relevant class of building blocks in chemical synthesis. However, uncontrollable selectivity towards azo compounds and low reactant conversion in traditional synthetic methods seriously impede their applications. Herein, Rb‐doped Au/CeO2 nanocatalyst (Rb‐Au/CeO2) was prepared and utilized as a highly efficient supported metal catalyst for the selective oxidation of anilines to azocompounds using hydrogen peroxide as an oxidant, which reached ultrahigh selectivity (92%) towards azoxybenzene and complete aniline conversion (100%). The addition of Rb+ accelerates the electron transformation of Au to produce Au+, which is ready for catalysis. This research presents a promising Rb‐doped strategy for achieving complete aniline conversion and high selectivity towards azoxybenzene, opening up new possibilities for the application of aromatic azo compounds in chemical synthesis.

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Rubidium doped nano-hydroxyapatite with cytocompatibility and antibacterial

Cited by 15 publications

References 41 publications

Synthesis of Rubidium-doped Calcium Hydroxyapatite Nanoparticles for Biomedical Applications

Synthesis of Rubidium-doped Calcium Hydroxyapatite Nanoparticles for Biomedical Applications

Evaluation of the effectiveness of nano-hydroxyapatite particles in wound healing in an animal study

Rb‐Promoted Au/CeO₂ Nanocatalyst for Remarkably‐Enhanced Aniline Conversion to Azoxybenzene with Ultrahigh Selectivity

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Rubidium doped nano-hydroxyapatite with cytocompatibility and antibacterial

Cited by 15 publications

References 41 publications

Synthesis of Rubidium-doped Calcium Hydroxyapatite Nanoparticles for Biomedical Applications

Synthesis of Rubidium-doped Calcium Hydroxyapatite Nanoparticles for Biomedical Applications

Evaluation of the effectiveness of nano-hydroxyapatite particles in wound healing in an animal study

Rb‐Promoted Au/CeO2 Nanocatalyst for Remarkably‐Enhanced Aniline Conversion to Azoxybenzene with Ultrahigh Selectivity

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Rb‐Promoted Au/CeO₂ Nanocatalyst for Remarkably‐Enhanced Aniline Conversion to Azoxybenzene with Ultrahigh Selectivity