Rubella Virus Is Associated With Fuchs Heterochromic Iridocyclitis

Groot-Mijnes, Jolanda D.F. de; Visser, Lenneke de; Rothová, Aniki; Schuller, Margje; Loon, Anton M. van; Weersink, A. J. L.

doi:10.1016/j.ajo.2005.07.078

Cited by 167 publications

(103 citation statements)

References 7 publications

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“…In Europe, Rubella virus infection was frequently linked to FHUS, whereas in Asia CMV has been reported as a frequent causal agent of FHUS. [5][6][7] In our report, one of the six FHUS patients was CMV positive by both real-time PCR and GWC analysis, whereas three FHUS patients were Rubella virus positive by GWC analysis. Our study shows that not only CMV but also rubella virus-associated AU may occur in Asia and cause the clinical features typical of FHUS.…”

Section: Discussionmentioning

confidence: 42%

“…With regard to the latter, it has been demonstrated, that PCR is usually positive in the early stage of viral disease, whereas the GWC becomes positive at later stages, but remains so for a longer period of time. 5 For Rubella virus, it has been reported consistently that the GWC is positive in virtually 100% of FHUS cases and that this virus is also strongly associated with incomplete cases of FHUS; PCR is of little value for the diagnosis of Rubella virus associated uveitis. 4,5,26,28,29 It has been shown that the sensitivity of diagnostic tests was influenced by the time interval between the onset of symptoms and sample collection.…”

Section: Discussionmentioning

confidence: 99%

“…5 For Rubella virus, it has been reported consistently that the GWC is positive in virtually 100% of FHUS cases and that this virus is also strongly associated with incomplete cases of FHUS; PCR is of little value for the diagnosis of Rubella virus associated uveitis. 4,5,26,28,29 It has been shown that the sensitivity of diagnostic tests was influenced by the time interval between the onset of symptoms and sample collection. 9 Our study included an insufficient number of patients to investigate these associations.…”

Section: Discussionmentioning

confidence: 99%

“…9,10 The Rubella virus ELISA were performed at the Virology Department of the University Medical Center Utrecht (Utrecht, The Netherlands) as described previously. 5 Total IgG concentrations were determined by an in-house ELISA using commercially available reagents. To calculate the total IgG concentration, seven serial twofold dilutions of a nephelometer N Protein standard SL (Dade Behring) were included.…”

Section: Methodsmentioning

confidence: 99%

“…Infectious causes of AU are increasingly being recognized; specifically cytomegalovirus (CMV) and Rubella virus have been reported as infectious causes of AU in immunocompetent patients. [3][4][5][6] Herpetic AU is considered the most common cause of infectious AU in the Western countries. 1 Recent study from Asia revealed that HIV-negative patients with hypertensive AU regularly had intraocular CMV infection.…”

Section: Introductionmentioning

confidence: 99%

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Viral causes of unexplained anterior uveitis in Thailand

Kongyai

Sirirungsi

Pathanapitoon

et al. 2012

Eye

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Aims To assess the possible role of virus infection in patients with unexplained anterior uveitis (AU). Methods Intraocular fluid and plasma samples of 30 HIV-negative AU patients who were unresponsive or poorly responsive to topical steroid therapy were analyzed for nucleic acid of cytomegalovirus (CMV), herpes simplex virus (HSV), and varicella zoster virus (VZV) by realtime polymerase chain reaction (PCR) and for intraocular antibodies against these viruses by Goldmann-Witmer coefficient (GWC) analysis. Of these 30 cases, 21 were tested for rubella virus by GWC analysis, 16 of which also had PCR assessment of aqueous for rubella virus. Results Viral uveitis determined by either real-time PCR and/or GWC was documented in 20 out of 30 patients (67%). Of 30 paired samples tested by both methods for HSV, CMV, and VZV, 15 showed positive results (CMV (10), HSV (4), and VZV (1)). Real-time PCR was positive in 8/15 (53%), whereas GWC was positive in 10/15 (67%). Out of 10 CMV-positive patients, four had endotheliitis, two had Posner-Schlossman syndrome, and one Fuchs heterochromic uveitis syndrome (FHUS). Five out of 21 (24%) samples tested by GWC for Rubella virus were positive, three of which exhibited clinical features of FHUS. Conclusions Our results indicate that CMV is a major cause of AU in Thailand and show that FHUS can be caused by both CMV and Rubella virus.

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Section: Discussionmentioning

confidence: 42%