Rubella Immunity in a Cohort of Pregnant Women

McElhaney, Robert D.; Ringer, Marilyn; DeHart, Del J.; Vasilenko, Peter

doi:10.1086/501558

Cited by 10 publications

(3 citation statements)

References 2 publications

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“…The prevalence rate of NRI demonstrated in this study appeared lower compared to previous studies in 1988 (7.5%–17.4%) [1], 1999 (15.4%) [2], and 2004 (9.1%) [3]. …”

Section: Discussioncontrasting

confidence: 93%

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Evaluation of Rubella Immunity in a Community Prenatal Clinic

Nwanegbo

Swanson²,

Vanderpuye

et al. 2013

ISRN Family Medicine

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Since the introduction of the Rubella vaccine in 1969, prevalence of congenital Rubella syndrome (CRS) has greatly declined in the United States. However, reports of sporadic adult cases of the disease and frequent identification of non-Rubella immune (NRI) women in prenatal units may result in outbreak of CRS in susceptible communities. Identifying populations with high rates of NRI will assist in evidence-based public health intervention that may prevent epidemic of CRS in the United States. Method. This is a retrospective, cross-sectional study involving chart audit of Rubella screening results of 642 women who attended a high-risk prenatal care at a northwestern Iowa clinic between January 1 and December 31, 2007. Results. NRI was found in 6.9% of the study population. The highest prevalence rate of 10.2% was found among adolescents. NRI was highest among Native American women at 17.3%, compared to Whites 7.3%, African Americans 5.9%, and Hispanics 4.6%. Multivariate analysis demonstrated that Native Americans were 2.5 times more likely to be NRI compared to Whites (OR 2.7; 95% CI: 1.1, 6.6). Conclusion. This study demonstrated higher rate of non-Rubella immunity among adolescent pregnant women and supports Rubella booster immunization for all non-pregnant teenage women. The observed high rate of NRI among Native Americans may require further studies and evaluation of Rubella vaccination programs in tribal communities.

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“…The prevalence rate of NRI demonstrated in this study appeared lower compared to previous studies in 1988 (7.5%–17.4%) [1], 1999 (15.4%) [2], and 2004 (9.1%) [3]. …”

Section: Discussioncontrasting

confidence: 93%

“…A study in 1988 suggested that between 7.5 and 17.4% of pregnant women in the United States lack immunity to Rubella [1]. Similarly, a prevalence rate of 15.1% among pregnant women was reported in 1999 by investigators in Michigan [2]. In addition, a rate of 9.1% was found among women who attended prenatal care at Lejeune NC in 2004 [3].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Rubella Immunity in a Community Prenatal Clinic

Nwanegbo

Swanson²,

Vanderpuye

et al. 2013

ISRN Family Medicine

View full text Add to dashboard Cite

show abstract

“…A rubella-specific antibody titer of <10 IU/ml usually equates susceptibility, predisposing to fetal congenital rubella syndrome (CRS) if infection occurs in pregnancy. Rubella susceptibility is influenced by age, immunization compliance, gravidity and parity, and country of origin/birth [11][12][13][14][15][16][17][18], the last factor probably being the most important as Asians and Chinese have either accounted for the majority of rubella seronegative women, or an overall lower rate of seropositivity or antibody titer, compared with Caucasians in multiethnic communities [11,13,14,18,19]. Country of origin/birth could also impact through epidemiological factors, such as chronic hepatitis B virus (HBV) infection, which was associated with increased antenatal rubella seronegative status in Hong Kong [20].…”

Section: Introductionmentioning

confidence: 99%