Rubella

Plotkin, Stanley А.; Reef, Susan E.; Cooper, Louis Z.; Alford, Charles A.

doi:10.1016/b978-1-4160-6400-8.00028-6

Cited by 26 publications

(50 citation statements)

References 484 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…16,17 In addition, the antibody titer of rubella-specific IgG in patients with CRS tends to be higher several months after birth than in neonates. 18 In the current case, rubella-specific IgG decreased until 3 months of age and increased at 4 months of age.…”

Section: Discussionmentioning

confidence: 99%

Congenital Rubella Syndrome: A Case Report on Changes in Viral Load and Rubella Antibody Titers

et al. 2016

View full text Add to dashboard Cite

To our knowledge, this is the first report of the use of real-time reverse transcription–polymerase chain reaction to assess changes in viral load in a patient with congenital rubella syndrome (CRS). Rubella-specific antibody titers were also determined. The patient was a male neonate born to a primipara with rubella infection at 10 weeks of gestation. He had no symptoms at birth, but rubella virus was detected in his pharynx, blood, and urine. His mental and physical development was normal for 1 year; however, he was diagnosed with deafness at 13 months of age. Thus, the patient was diagnosed with CRS. Rubella infection in the pharynx was almost constant until 5 months of age; however, it increased dramatically at 6 months of age. No infection was detected at 13 months. Rubella-specific immunoglobulin M titer was consistently low until 9 months of age and then decreased gradually until it became negative at 20 months of age. Rubella-specific immunoglobulin G titer was high at birth. However, it decreased at 3 months and increased again at 4 months. This titer peaked at ∼9 months and then decreased again at 13 months. This case shows that the period after the decline in maternal antibody titers, not the neonatal period, may be the most contagious period in patients with CRS.

show abstract

Section: Discussionmentioning

confidence: 99%

Congenital Rubella Syndrome: A Case Report on Changes in Viral Load and Rubella Antibody Titers

et al. 2016

View full text Add to dashboard Cite

show abstract

“…2,4,11 For instance, an 11 year-old boy with mumps traveling from the United Kingdom in 2009 transmitted the disease to people susceptible to exposure in New York, eventually spreading across the East Coast and into Canada. 1,11 Over half (53%) of the reported cases from this multi-state outbreak involved school-aged children (ages [5][6][7][8][9][10][11][12][13][14][15][16][17]. This is likely due to their close and consistent contact at school.…”

Section: Epidemiologymentioning

confidence: 99%

“…3 Transmission occurs via contact with droplets from infected individuals during the last week of the two-to three-week incubation period, until a week post-development of the stereotypic rubella rash. 3,6 Individuals with asymptomatic or subclinical infections may also transmit the disease. Additionally, infants with CRS shed large quantities of the rubella virus from their bodily secretions for more than a year post-parturition and are highly contagious.…”

Section: Populations Susceptible To Exposurementioning

confidence: 99%

“…16 While the current recommended schedule is to receive the first dose at 12-15 months followed by the second dose at 4-6 years (before elementary school enrollment), vaccine status should be assessed at every medical encounter and individuals due for a dose of MMR vaccine should receive the vaccine at that time. [1][2][3][4][5][6]14,17 Receipt of the two-dose MMR series is strongly advised for eligible, non-pregnant women at least 28 days apart with completion no less than one month before conception. [1][2][3][4][5][6][7]18 Counseling is recommended to discuss both the importance of not becoming pregnant for at least 28 days following the MMR vaccine series because of the theoretical risk posed by the live albeit attenuated vaccine viruses.…”

Section: Dosage and Schedulementioning

confidence: 99%

“…[1][2][3][4][5][6][7][8][9] The most concerning of these is rubella as it can cause congenital rubella syndrome (CRS) with devastating effects. 3,4,6,7 In this review, we consider each of the diseases in turn and address the role of vaccination in preventing these diseases and their complications.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Measles, Mumps and Rubella

Preedy¹,

Watson²

2010

Handbook of Disease Burdens and Quality of Life Measures

View full text Add to dashboard Cite

Measles, mumps, and rubella are viral diseases that may adversely affect non-immune pregnant women and their fetuses/neonates. Prevention of these diseases and their complications can be achieved through measles-mumps-rubella (MMR) vaccination prior to pregnancy. The vaccine is contraindicated during pregnancy because it contains live, attenuated viruses that pose a theoretical risk to the fetus. However, accidental receipt of MMR vaccination is not known to cause maternal/fetal complications. MMR immunization is recommended to non-immune obstetric patients upon completion or termination of pregnancy.

show abstract