[Ru(bpy)3]2+ doped mesoporous carbon nanospheres as enhanced ECL luminophore for ultrasensitive detection of β-hydroxybutyric acid

Li, Jiangwei; Hu, Yue; Yang, Jiao; Li, Yingchun

doi:10.1016/j.snb.2023.134562

Cited by 4 publications

(3 citation statements)

References 29 publications

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“…In recent years, metal–organic frameworks (MOFs) have garnered increased attention in ECL sensors due to their ordered porosity and ultrahigh specific surface area, which greatly enhance the loading amount of chromophores. − The ECL chromophores used in reported MOF-based ECL sensors predominantly consist of luminol, Ru(bpy) 3 2+ (where bpy represents 2,2′-bipyridine) or their derivatives, which are incorporated into the MOF using modification, encapsulation, or doping. − However, two main issues remain. First, the MOF materials synthesized using this method exhibit poor stability in aqueous environments and previously reported MOF-based ECL sensors still face issues with chromophore leakage .…”

Section: Introductionmentioning

confidence: 99%

Aggregation-Induced ECL Immunosensor Using Ligand-Mediated Highly Stable Tetraphenylethene-Based Zinc Metal–Organic Frameworks for the Detection of 5-Fluorouracil

Tan,

Qian,

et al. 2024

ACS Appl. Nano Mater.

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Tetraphenylene (TPE) and its derivatives are highly studied materials in the field of aggregation-induced electrochemiluminescence (AIECL). We successfully synthesized a block-like metal−organic framework by employing Zn 2+ and the TPE-based ligand H 8 ETTB (H 8 ETTB = 4′,4‴,4‴″,4‴‴′-(ethene-1,1,2,2-tetrayl) tetrakis (([1,1′-biphenyl]-3,5dicarboxylic acid))), which demonstrates excellent ECL properties. For simplicity, we refer to this material as the Zinc-based metal−organic framework (Zn-MOF). H 8 ETTB is a ligand and luminophore, increasing the loading of the luminophore. The Zn-MOF exhibits considerable specific surface area and porous structure, which enables efficient reaction between the luminophores and coreactants, resulting in excellent ECL. The ECL emission of Zn-MOF is more intense than that of the H 8 ETTB monomer and aggregates. Due to the distinctive ECL characteristics of Zn-MOF, we employed it as an ECL luminophore in an ECL immunoassay, resulting in the establishment of an ECL system for the extremely sensitive detection of 5-fluorouracil. PdAu nanoflowers (PdAu NFs) were utilized as electrodes, which were modified because of their considerable specific surface area and electrocatalytic efficiency. As a result, they additionally improved the ECL performance. The design of the immunosensor is relatively straightforward, facilitating their manufacture. Furthermore, the immunosensor was successfully tested in human serum samples, demonstrating comparable detection results to those obtained using high-performance liquid chromatography with tandem mass spectrometry (HPLC-MS/MS). This research thus offers a practical method to enhance the performance of ECL and introduces an approach for identifying 5-FU in clinical analysis.

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Section: Introductionmentioning

confidence: 99%

Aggregation-Induced ECL Immunosensor Using Ligand-Mediated Highly Stable Tetraphenylethene-Based Zinc Metal–Organic Frameworks for the Detection of 5-Fluorouracil

Tan,

Qian,

et al. 2024

ACS Appl. Nano Mater.

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“…Recently, various analytical approaches including electrochemistry, , colorimetry, , surface plasmon resonance, fluorescence, , and electrochemiluminescence (ECL) measurents have been designed for monitoring the α-Glu activity. Among them, ECL is considered a powerful analytical technique because of its significant advantages of rapid response, simplicity, high sensitivity, and low background. , …”

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confidence: 99%

“…Among them, ECL is considered a powerful analytical technique because of its significant advantages of rapid response, simplicity, high sensitivity, and low background. 12,13 ECL is an electrochemically induced optical radiation process through energy relaxation of excited species, 14 but the ECL signal is prone to errors resulting from environmental factors. 15 Thus, it is essential to develop an efficient ECL platform with the integration of new mechanisms and modern analytical techniques.…”

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confidence: 99%

Exogenous Co-Reactant-Free Electrochemiluminescent Biosensor for Ratiometric Measurement of α-Glucosidase Based on a ZIF-67-Regulated Hydrogen-Bonded Organic Framework

Cui,

Yang,

Jiang

et al. 2024

ACS Sens.

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The development of highly sensitive and selective analytical approaches for monitoring enzymatic activity is critical for disease diagnosis and biomedical research. Herein, we develop an exogenous co-reactant-free electrochemiluminescence (ECL) biosensor for the ratiometric measurement of α-glucosidase (α-Glu) based on a zeolitic imidazolate framework (ZIF-67)regulated pyrene-based hydrogen-bonded organic framework (HOF-101). Target α-Glu can hydrolyze maltose to α-D-glucose, which can subsequently react with GO x to produce gluconic acid. The resultant gluconic acid can dissolve ZIF-67, leading to the recovery of the HOF-101 cathodic ECL signal and the decrease of the luminol anodic ECL signal. The long-range ordered structure of HOF-101 can speed up charge transfer, resulting in a stable and strong cathodic ECL signal. Moreover, ZIF-67 can not only efficiently quench the ECL signal of HOF-101 due to ECL resonance energy transfer between HOF-101 and ZIF-67 as well as the steric hindrance effect of ZIF-67 but also enhance the anodic ECL emission of luminol in dissolved O 2 system because of its ordered and porous crystalline structure and the atomically dispersed Co 2+ . Notably, HOF-101 possesses a higher ECL efficiency (32.22%) compared with the Ru(bpy) 3 2+ standard. Importantly, this ratiometric ECL biosensor shows high sensitivity (a detection limit of 0.19 U L −1 ) and a broad linear range (0.2−50 U L −1 ). This biosensor can efficiently eliminate systematic errors and enhance detection reliability without the involvement of exogenous co-reactants, and it displays good assay performance in human serum samples, holding great promise in biomedical research studies.

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Combination of core-shell structured NH2-UiO-66@ZIF-8 loaded Ru (bpy)3 2+ and molecularly imprinted copolymer for the sensitive ECL detection of tetracycline

Zhong,

Wang,

Zhao

et al. 2024

Microchim Acta

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[Ru(bpy)3]2+ doped mesoporous carbon nanospheres as enhanced ECL luminophore for ultrasensitive detection of β-hydroxybutyric acid

Cited by 4 publications

References 29 publications

Aggregation-Induced ECL Immunosensor Using Ligand-Mediated Highly Stable Tetraphenylethene-Based Zinc Metal–Organic Frameworks for the Detection of 5-Fluorouracil

Aggregation-Induced ECL Immunosensor Using Ligand-Mediated Highly Stable Tetraphenylethene-Based Zinc Metal–Organic Frameworks for the Detection of 5-Fluorouracil

Exogenous Co-Reactant-Free Electrochemiluminescent Biosensor for Ratiometric Measurement of α-Glucosidase Based on a ZIF-67-Regulated Hydrogen-Bonded Organic Framework

Combination of core-shell structured NH2-UiO-66@ZIF-8 loaded Ru (bpy)3 2+ and molecularly imprinted copolymer for the sensitive ECL detection of tetracycline

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