RTOG quality assurance guidelines for clinical trials using hyperthermia administered by ultrasound

Waterman, Frank M.; Dewhirst, Mark W.; Fessenden, Peter; Samulski, Thaddeus V.; Stauffer, Paul R.; Emami, Bahman; Corry, Peter M.; Prionas, Stavros D.; Sapozink, Michael D.; Herman, TS; Kapp, Daniel S.; Myerson, Robert J.; Ryan, Thomas P.; Sapareto, Stephen A.; Shrivastava, Prakash N.

doi:10.1016/0360-3016(91)90211-l

Cited by 37 publications

(6 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These were based largely on the idea of using multi-sensor probes or single sensor probes that can be moved inside a pre-placed catheter that is placed inside a tumour during treatment [47]. Guidelines for acquisition of multi-point thermometry data were published several years ago [48][49][50][51][52][53] and are in the process of being updated, under sponsorship of the thermal therapy societies in the US and Europe.…”

Section: Redefining Thermal Goals For Hyperthermia Treatmentmentioning

confidence: 99%

Re-setting the biologic rationale for thermal therapy

Dewhirst

Vujašković

Jones

et al. 2005

International Journal of Hyperthermia

282

199

View full text Add to dashboard Cite

This review takes a retrospective look at how hyperthermia biology, as defined from studies emerging from the late 1970s and into the 1980s, mis-directed the clinical field of hyperthermia, by placing too much emphasis on the necessity of killing cells with hyperthermia in order to define success. The requirement that cell killing be achieved led to sub-optimal hyperthermia fractionation goals for combinations with radiotherapy, inappropriate sequencing between radiation and hyperthermia and goals for hyperthermia equipment performance that were neither achievable nor necessary. The review then considers the importance of the biologic effects of hyperthermia that occur in the temperature range that lies between that necessary to kill substantial proportions of cells and normothermia (e.g. 39-42 degrees C for 1 h). The effects that occur in this temperature range are compelling-including inhibition of radiation-induced damage repair, changes in perfusion, re-oxygenation, effects on macromolecular and nanoparticle delivery, induction of the heat shock response and immunological stimulation, all of which can be exploited to improve tumour response to radiation and chemotherapy. This new knowledge about the biology of hyperthermia compels one to continue to move the field forward, but with thermal goals that are eminently achievable and tolerable by patients. The fact that lower temperatures are incorporated into thermal goals does not lessen the need for non-invasive thermometry or more sophisticated hyperthermia delivery systems, however. If anything, it further compels one to move the field forward on an integrated biological, engineering and clinical level.

show abstract

Section: Redefining Thermal Goals For Hyperthermia Treatmentmentioning

confidence: 99%

Re-setting the biologic rationale for thermal therapy

Dewhirst

Vujašković

Jones

et al. 2005

International Journal of Hyperthermia

282

199

View full text Add to dashboard Cite

show abstract

“…(115) RTOG quality assurance guidelines for interstitial hyperthermia (116) and ultrasound. (117) Recently, leading experts in the United States published a review of the competencies and tasks used in a hyperthermia clinic. Guidelines were provided for what the competencies specialist involved in delivery of care including physicians, physicists and technologists need to perform multiple tasks to ensure properly functioning equipment, appropriate patient selection, and to plan and administer hyperthermia treatment.…”

Section: Challenges To Clinical Implementationmentioning

confidence: 99%

Hyperthermia, Radiation and Chemotherapy: The Role of Heat in Multidisciplinary Cancer Care

Hurwitz

Stauffer

2014

Seminars in Oncology

119

104

View full text Add to dashboard Cite

“…Although the experimental conditions were not explicitly simulated, the temperatures and fluctuations measured may have been smaller mainly because of thermal conduction along the hypodermic needles (Waterman et al 1991) and lower output power. Absorption heating artifacts are obviously precluded and those caused by viscous heating and acoustic scattering are small due to thermal smearing by both conduction and convection.…”

Section: Discussionmentioning

confidence: 97%

“…The needles were also necessary to protect the fibreoptic probes from direct ultrasound exposure. Thermal conduction artifacts can be considered equivalent to positioning errors usually on the order of 1 mm for thermocouples (Waterman et al 1991). Even if the equivalent positioning error is larger than 1 mm for hypodermic needles, for the purpose of this investigation-namely the quantification of the temperature fluctuations, thermal conduction artifacts are not critical.…”

Section: Discussionmentioning

confidence: 99%

Numerical andin vitroevaluation of temperature fluctuations during reflected-scanned planar ultrasound hyperthermia

Moros

Fan

Straube

et al. 1998

International Journal of Hyperthermia

View full text Add to dashboard Cite

Temperature fluctuations inside a target volume during reflected-scanned planar ultrasound hyperthermia were investigated numerically and in vitro. The numerical approach consisted of integrating an ultrasonic power deposition model for a scanning ultrasound reflector linear array system (SURLAS) designed for simultaneous thermoradiotherapy, and a three-dimensional transient version of Pennes' bioheat transfer equation. The in vitro approach consisted of delivering hyperthermia to a fixed-perfused canine kidney phantom using a SURLAS prototype. Both approaches allowed the study of temperature fluctuations for several important clinically relevant parameters: scan time, scan distance, perfusion rate and skin cooling. The simulation results showed that the largest temperature fluctuations were located at the opposite ends of the scan window where the scanning reflector comes to a sudden and complete stop and reverses direction. The smallest fluctuations were located at the centre of the scan window. For a given scan distance, the magnitude of the temperature fluctuations increased linearly with increasing scan time, and increased almost linearly as a function of blood perfusion rate. For a scan window of 10 cm x 10 cm and a blood perfusion rate of 5 kg/m3 s, the simulated temperature fluctuations were within +/- 0.5 degree C from the average temperature for scan times less than or equal to 20 s. The in vitro results agreed well with the numerical findings. The measured temperature fluctuations were less than 1.0 degree C for flow rates into the renal artery of less than 200 ml/min and scan times less than 20 s.

show abstract

RTOG quality assurance guidelines for clinical trials using hyperthermia administered by ultrasound

Cited by 37 publications

References 29 publications

Re-setting the biologic rationale for thermal therapy

Re-setting the biologic rationale for thermal therapy

Hyperthermia, Radiation and Chemotherapy: The Role of Heat in Multidisciplinary Cancer Care

Numerical andin vitroevaluation of temperature fluctuations during reflected-scanned planar ultrasound hyperthermia

Contact Info

Product

Resources

About