2014
DOI: 10.1212/wnl.0000000000000280
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rTMS in fibromyalgia

Abstract: This study provides Class II evidence that rTMS compared with sham rTMS improves QoL in patients with fibromyalgia.

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Cited by 95 publications
(91 citation statements)
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“…NIBS techniques including repetitive transcranial magnetic stimulation 5,24,30 and tDCS 14,37,42 over M1 have been shown to have significant analgesic effects in FM, possibly through modification of the sensory components of pain by thalamic inhibitory networks.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…NIBS techniques including repetitive transcranial magnetic stimulation 5,24,30 and tDCS 14,37,42 over M1 have been shown to have significant analgesic effects in FM, possibly through modification of the sensory components of pain by thalamic inhibitory networks.…”
Section: Discussionmentioning
confidence: 99%
“…9 Several studies 5,14,24,30,37,42 have shown that stimulation of this brain area can induce significant analgesic effects in FM, mainly through modification in sensory processing of pain by thalamic inhibitory networks. Nonetheless, the results are inconsistent and some studies have achieved only marginal benefits.…”
mentioning
confidence: 99%
“…Another problem with rTMS studies in the PD population is the lack of HRQoL measurements. While several rTMS studies on depression [34], schizophrenia [35], or chronic pain [36] also evaluated the changes in HRQoL, the authors of the present study were able to identify only one paper utilizing HRQoL in a PD population [37] (PubMed keywords: PDQ-39 and rTMS and PD; SF-36 and rTMS and PD, and EQ-5D and rTMS and PD, assessed on December 28, 2014). That open-label and noncontrolled study investigated the efficacy of rTMS of the dorsolateral prefrontal cortex combined with the application of acetylcholinesterase inhibitor (galantamine) therapy in 30 PD patients with cognitive impairment and a higher level of gait disorders.…”
Section: Discussionmentioning
confidence: 99%
“…rTMS is able to modulate cortical and deep brain areas through its electromagnetic field generated over the scalp, either decreasing (when using low‐frequency protocols) or increasing (via high frequency stimulation) cortical excitability . Clinical and experimental evidence indicates that in patients with FM, rTMS may exert its effect through modulatory pain pathways such as the descending inhibitory pathways and modulating social‐affective regions of the brain such as the right temporal lobe . Although there are randomized clinical trials of good quality suggesting favorable results, there is no consensus regarding the efficacy of rTMS on FM, neither on the optimal parameters of stimulation.…”
Section: Introductionmentioning
confidence: 99%