RSNA/QIBA: Shear wave speed as a biomarker for liver fibrosis staging

Hall, Timothy J.; Milkowski, Andy; Garra, Brian S.; Carson, Paul L.; Palmeri, Mark L.; Nightingale, Kathryn R.; Lynch, Ted; Alturki, Abdullah; André, Michael P.; Audière, Stéphane; Bamber, Jeffrey C.; Barr, Richard G.; Bercoff, Jérémy; Bercoff, Jessica; Bernal, Miguel; Brum, Javier; Chan, Huan Wee; Chen, Shigao; Cohen‐Bacrie, Claude; Couade, Mathieu; Daniels, Allison; DeWall, Ryan J.; Dillman, Jonathan R.; Ehman, Richard L.; Franchi‐Abella, Stéphanie; Fromageau, J.; Gennisson, Jean‐Luc; Henry, J.; Ivancevich, Nikolas M.; Kalin, Jan; Kohn, Sarah; Kugel, Jennifer L.; Lee, Ken; Liu, N. I.; Loupas, T.; Mazernik, Joan; McAleavey, Stephen A.; Miette, Véronique; Metz, Steve; Morel, Baptiste; Nelson, Thomas R.; Nordberg, Eric P; Oudry, Jennifer; Padwal, Monali; Rouze, Ned C.; Samir, Anthony E.; Sandrin, Laurent; Schaccitti, Janet; Schmitt, Cédric; Shamdasani, Vijay; Song, Pengfei; Switalski, Pamela; Wang, Michael; Wear, Keith A.; Xie, Hua; Zhao, Heng

doi:10.1109/ultsym.2013.0103

Cited by 91 publications

(118 citation statements)

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“…A marker of disease activity, proteinuria, has been mentioned in the literature as an influencing factor for kidney SWV [27], but we found no significant correlation between proteinuria and kidney SWV in our patients.…”

Section: Discussioncontrasting

confidence: 94%

“…Another factor that influenced kidney SWV in our subjects was the depth of measurement; the decrease of the measured SWV was previously related to an increase in depthin studies performed on phantoms [26,27] or liver [28,29]. A marker of disease activity, proteinuria, has been mentioned in the literature as an influencing factor for kidney SWV [27], but we found no significant correlation between proteinuria and kidney SWV in our patients.…”

Section: Discussionmentioning

confidence: 47%

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Is there a correlation between kidney shear wave velocity measured with VTQ and histological parameters in patients with chronic glomerulonephritis? A pilot study

Bob¹,

Grosu²,

Sporea³

et al. 2018

Med Ultrason

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Aim: To analyze the relationship between shear wave velocity in the kidney measured by point shear wave elastography using Virtual Touch Quantification (VTQ) (Siemens Acuson S2000) and histological parameters obtained from renal biopsies, in patients with chronic glomerulonephritis (CGN).Material and methods: The study group included 20 patients (mean age 47.95±13.59 years) with different types of CGN, that had underwent renal biopsy and 57 normal controls (mean age 38.07±17.32 years). In all patients, five valid stiffness measurements were obtained in each kidney, with the patient in lateral decubitus. Regarding the histological results, we assessed the presence or absence of glomerulosclerosis, interstitial fibrosis, and arteriolo-hyalinosis.Results: In patients with CGN we obtained the following mean values of VTQ values: right kidney: 2.12±0.81 m/s, left kidney 1.65±0.54 m/s, while in the normal controls significantly higher VTQ values were obtained: right kidney 2.69±0.72 m/s (p=0.004), left kidney 2.48±0.73 m/s (p<0.0001). In patients with CGN no statistically significant correlations between VTQ values and eGFR (r=0.37, p=0.12) or proteinuria (r=0.2, p=0.37) were found. We found significantly lower VTQ values in patients with interstitial fibrosis (1.46 vs. 1.99 m/s, p<0.05) and also in patients with arteriolo-hyalinosis (1.55 vs. 2.47 m/s, p<0.05).Conclusion: Our pilot study shows that shear wave velocity values in patients with CGN are significantly lower compared to normal controls, and there is a tendency to decrease with the decrease of eGFR, with the presence of interstitial fibrosis and of arteriolo-hyalinosis.

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Section: Discussioncontrasting

confidence: 94%

Section: Discussionmentioning

confidence: 47%

Is there a correlation between kidney shear wave velocity measured with VTQ and histological parameters in patients with chronic glomerulonephritis? A pilot study

Bob¹,

Grosu²,

Sporea³

et al. 2018

Med Ultrason

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“…As shown by the studies on phantoms [129], the influence of depth on the estimation of elastic properties is not negligible. Furthermore, with curved transducers used in liver imaging, the angle affects the readings, with the best results being achieved when the ROI is straight ahead.…”

Section: Measurement Depthmentioning

confidence: 92%

“…An inter-laboratory study comparing shear wave velocities obtained with four different machines (Fibroscan, Philips iU22, ACUSON S2000 and Aixplorer) was conducted [129]. Working on elastic phantoms, a statistically significant difference in the SWS estimates among systems and depth of measurement in the phantom was shown, whereas no statistically significant differences were found among operators using the same or equivalent systems under the same conditions [129]. Similar results were obtained using phantoms with viscoelastic properties similar to those observed in normal and fibrotic liver [130].…”

Section: Studies On Phantomsmentioning

confidence: 99%

Untitled

2017

Ultraschall in Med

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“…The first moment x m of the WSRx speckle signal at axial position z was calculated as (2) where x n is the lateral position of the n th A-line. The lateral peak x p (z) was determined from the maximum of the WSRx at a given axial position z.…”

Section: A Simulationsmentioning

confidence: 99%

Shear wave arrival time estimates correlate with local speckle pattern

McAleavey

Langdon

Osapoetra

2014

2014 IEEE International Ultrasonics Symposium

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We present simulation and phantom studies demonstrating a strong correlation between errors in shear wave arrival time estimates and the lateral position of the local speckle pattern in targets with fully developed speckle. We hypothesize that the observed arrival time variations are largely due to the underlying speckle pattern, and call the effect speckle bias. Arrival time estimation is a key step in quantitative shear wave elastography, performed by tracking tissue motion via cross correlation of RF ultrasound echoes or similar methods. Variations in scatterer strength and interference of echoes from scatterers within the tracking beam result in an echo that does not necessarily describe the average motion within the beam, but one favoring areas of constructive interference and strong scattering. A swept-receive image, formed by fixing the transmit beam and sweeping the receive aperture over the region of interest, is used to estimate the local speckle pattern. Metrics for the lateral position of the speckle are found to correlate strongly (r>0.7) with the estimated shear wave arrival times both in simulations and in phantoms. Lateral weighting of the swept-receive pattern improved the correlation between arrival time estimates and speckle position. The simulations indicate that high RF echo correlation does not equate to an accurate shear wave arrival time estimate -a high correlation coefficient indicates that motion is being tracked with high precision, but the location tracked is uncertain within the tracking beam width. The presence of a strong on-axis speckle is seen to imply high RF correlation and low bias. The converse does not appear to be true -highly correlated RF echoes can still produce biased arrival time estimates. The shear wave arrival time bias is relatively stable with variations in shear wave amplitude and sign (−20 μm to 20 μm simulated) compared to the variation with different speckle realizations obtained along a given tracking vector. We show that the arrival time bias is weakly dependent on shear wave amplitude compared to the variation with axial position/local speckle pattern. Apertures of f/3 to f/8 on transmit and f/2 and f/4 on receive were simulated. Arrival time error and correlation with speckle pattern are most strongly determined by the receive aperture.

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RSNA/QIBA: Shear wave speed as a biomarker for liver fibrosis staging

Cited by 91 publications

References 1 publication

Is there a correlation between kidney shear wave velocity measured with VTQ and histological parameters in patients with chronic glomerulonephritis? A pilot study

Is there a correlation between kidney shear wave velocity measured with VTQ and histological parameters in patients with chronic glomerulonephritis? A pilot study

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Shear wave arrival time estimates correlate with local speckle pattern

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