RSK2 inactivation cooperates with AXIN1 inactivation or β-catenin activation to promote hepatocarcinogenesis

Schaeffer, Samantha; Gupta, Bhavana; Calatayud, Anna-Line; Caldéraro, Julien; Caruso, Stefano; Hirsch, Théo Z.; Pelletier, Laura; Zucman‐Rossi, Jessica; Rebouissou, Sandra

doi:10.1016/j.jhep.2023.05.004

Cited by 2 publications

(1 citation statement)

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“…Recent studies have demonstrated that adenovirus-mediated transfer of wild-type AXIN1 gene can elicit apoptosis in HCC and CRC cells that have accumulated β-catenin due to APC, CTNNB1 or AXIN1 mutation [89]. RSK2-inactivating mutations frequently co-occur with AXIN1-inactivating or β-cateninactivating mutations, which play a synergistic role in promoting HCC development [92]. RNF43, as a E3 ubiquitin-protein ligase, exerts inhibitory effect on Wnt/β-catenin by mediating FZD ubiquitination followed by lysosomal degradation.…”

Section: Mechanisms Of Activation Of the Wnt/β-catenin Signaling Path...mentioning

confidence: 99%

Wnt/β-catenin signaling pathway in carcinogenesis and cancer therapy

Song,

Gao,

Bao

et al. 2024

J Hematol Oncol

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The Wnt/β-catenin signaling pathway plays a crucial role in various physiological processes, encompassing development, tissue homeostasis, and cell proliferation. Under normal physiological conditions, the Wnt/β-catenin signaling pathway is meticulously regulated. However, aberrant activation of this pathway and downstream target genes can occur due to mutations in key components of the Wnt/β-catenin pathway, epigenetic modifications, and crosstalk with other signaling pathways. Consequently, these dysregulations contribute significantly to tumor initiation and progression. Therapies targeting the Wnt/β-catenin signaling transduction have exhibited promising prospects and potential for tumor treatment. An increasing number of medications targeting this pathway are continuously being developed and validated. This comprehensive review aims to summarize the latest advances in our understanding of the role played by the Wnt/β-catenin signaling pathway in carcinogenesis and targeted therapy, providing valuable insights into acknowledging current opportunities and challenges associated with targeting this signaling pathway in cancer research and treatment.

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Section: Mechanisms Of Activation Of the Wnt/β-catenin Signaling Path...mentioning

confidence: 99%