RSC: Gel dosimetry as a tool for clinical implementation of image-guided radiotherapy

Elter, A.; Dorsch, S.; Marot, M; Gillmann, Clarissa; Johnen, W.; Runz, A.; Spindeldreier, C.K.; Klüter, Sebastian; Karger, Christian P.; Mann, P.

doi:10.1088/1742-6596/2167/1/012020

Cited by 4 publications

(3 citation statements)

References 7 publications

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“…In another study, Elter et al (2022) used (i) a cylindrical motion phantom and (ii) a porcine lung phantom equipped with PG dosimeters to test IFMM by an MR-Linac system. Dose was delivered while the phantoms were simulating a breathing pattern and the PG container was tracked by the MR Imaging system.…”

Section: Moving Targetsmentioning

confidence: 99%

Validation of complex radiotherapy techniques using polymer gel dosimetry

Karger,

Elter,

Dorsch

et al. 2024

Phys. Med. Biol.

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Modern radiotherapy delivers highly conformal dose distributions to irregularly shaped target volumes while sparing the surrounding normal tissue. Due to the complex planning and delivery techniques, dose verification and validation of the whole treatment workflow by end-to-end tests became much more important and polymer gel dosimeters are one of the few possibilities to capture the delivered dose distribution in 3D. The basic principles and formulations of gel dosimetry and its evaluation methods are described and the available studies validating device-specific geometrical parameters as well as the dose delivery by advanced radiotherapy techniques, such as 3D-CRT/IMRT and SRS treatments, the treatment of moving targets, online-adaptive MRgRT as well as proton and ion beam treatments, are reviewed. The present status and limitations as well as future challenges of polymer gel dosimetry for the validation of complex radiotherapy techniques are discussed.

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Section: Moving Targetsmentioning

confidence: 99%

Validation of complex radiotherapy techniques using polymer gel dosimetry

Karger,

Elter,

Dorsch

et al. 2024

Phys. Med. Biol.

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“…[98]). Some specific developments and applications for E2E QA to evaluate specific clinical treatment protocols are referenced in Table 1 below (which presents a list of vendors that supply various commercial tools and services to aid in-house E2E testing) and in the most recent IC3Ddose proceedings from the virtual meeting in 2021 [99][100][101][102][103]. These and other [21,53,96,[104][105][106][107][108][109][110][111][112] clinical reports span a range of investigations into the feasibility of RT E2E testing, nonetheless they do make some common observations.…”

Section: Lessons Learned From Past Radiation Therapy E2e Testingmentioning

confidence: 99%

End-to-End QA in Radiation Therapy Quality Management

Schreiner

2023

J. Phys.: Conf. Ser.

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End-to-End (E2E) testing is a method originating from computer science that is designed to determine whether an application communicates as required with hardware, networks, databases, and other applications. This paper is to advocate that the quality management (QM) of modern radiation therapy (RT) would benefit from more regular use of E2E based quality assurance (QA) in the local clinic. The argument is that modern RT delivery is performed through some process linked by a chain of interdependent stages and actions mediated by complex interchanges during the patient’s treatment. These actions along the chain are often modified due to decisions by clinical staff who are interpreting information acquired along the process. While physics QA can validate that each of these steps are technically achievable (e.g., through machine QA) such conventional QA does not guarantee that the overall process is being carried out as planned even when it has been described by a well-defined protocol and delivered by well-trained staff. The paper briefly reviews the changes in programmatic design as RT has become more complex, the associated changes in RT QM, and some past examples of E2E testing in RT clinics, usually performed during the implementation of some new RT technique or during external audits of the clinic’s practice. The paper then makes the case for increased E2E QA based on the lessons learned from this experience and ends with some suggestions for implementing effective and sustainable E2E testing in a clinic’s QM program.

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“…Irradiation-induced polymerization of BANG gels affects the mobility of surrounding water molecules and, hence, the spin-spin relaxation (R2) rate of NMR. Polymer dosimeters are suitable for quality assurance in radiotherapy [37][38][39]. Recently, Kudrevicius et al used modified PAG dosimeters for quality assurance in stereotactic radiosurgery treatments.…”

Section: Polymer Dosimetersmentioning

confidence: 99%

Recent Advances in Hydrogel-Based Sensors Responding to Ionizing Radiation

Zhang

Jiang

Chen

et al. 2022

Gels

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Ionizing radiation and its applications are widely spread throughout life. Similar to many other things, both the positive and negative aspects of ionizing radiation should always be kept in mind. For example, a proper radiation dose can be delivered to tumor tissue to kill malignant cells in radiotherapy. On the other hand, exceeding this dose can damage the normal tissues of a human organism. Therefore, the application of sensors for measuring ionizing radiation doses is of utmost importance in many fields, especially in cancer therapy. Traditional dosimeters, such as ionization chambers, silicon diodes and thermoluminescence dosimeters, are widely used. However, they have limitations in certain aspects. Hydrogel-based sensors (or dosimeters) for measuring ionizing radiation doses attract extensive attention for decades due to their equivalence to living tissue and biocompatibility. In this review, we catalog hydrogel-based dosimeters such as polymer, Fricke, radio-chromic, radio-fluorescence and NPs-embedded dosimeters. Most of them demonstrate desirable linear response and sensitivity regardless of energy and dose rate of ionizing radiation. We aim to review these dosimeters and their potential applications in radiotherapy as well as to stimulate a joint work of the experts from different fields such as materials science, chemistry, cancer therapy, radiobiology and nuclear science.

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RSC: Gel dosimetry as a tool for clinical implementation of image-guided radiotherapy

Cited by 4 publications

References 7 publications

Validation of complex radiotherapy techniques using polymer gel dosimetry

Validation of complex radiotherapy techniques using polymer gel dosimetry

End-to-End QA in Radiation Therapy Quality Management

Recent Advances in Hydrogel-Based Sensors Responding to Ionizing Radiation

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