RPE Histopathology and Morphometry

Szalai, Eszter; Nickerson, John M.; Grossniklaus, Hans E.

doi:10.1007/978-3-030-28384-1_1

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2023

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“…The retinal pigment epithelium (RPE), a highly specialized polarized monolayer between the neuroretina and the nourishing underlying choroid, has a major impact on retinal health and diseases [ 1 – 3 ]. It’s apical membrane faces the photoreceptor outer segments and interphotoreceptor matrix [ 4 ], whereas the RPE’s basal lamina is part of Bruch’s membrane [ 1 ]. Furthermore, tight junctions between neighboring RPE cells complete the outer blood-retinal barrier.…”

Section: Introductionmentioning

confidence: 99%

Real-time OCT feedback-controlled RPE photodisruption in ex vivo porcine eyes using 8 microsecond laser pulses

Burri,

Salzmann,

Wandel

et al. 2023

Biomed. Opt. Express

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Selective retinal pigment epithelium (RPE) photodisruption requires reliable real-time feedback dosimetry (RFD) to prevent unwanted overexposure. In this study, optical coherence tomography (OCT) based RFD was investigated in ex vivo porcine eyes exposed to laser pulses of 8 µs duration (wavelength: 532 nm, exposure area: 90 × 90 µm2, radiant exposure: 247 to 1975 mJ/µm2). For RFD, fringe washouts in time-resolved OCT M-scans (central wavelength: 870 nm, scan rate: 85 kHz) were compared to an RPE cell viability assay. Statistical analysis revealed a moderate correlation between RPE lesion size and applied treatment energy, suggesting RFD adaptation to inter- and intraindividual RPE pigmentation and ocular transmission.

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