Rp3: Ribosome profiling-assisted proteogenomics improves coverage and confidence during microprotein discovery
Eduardo Vieira de Souza,
Angie L. Bookout,
Christopher A. Barnes
et al.
Abstract:There has been a dramatic increase in the identification of non-canonical translation and a significant expansion of the protein-coding genome. Among the strategies used to identify unannotated small Open Reading Frames (smORFs) that encode microproteins, Ribosome profiling (Ribo-Seq) is the gold standard for the annotation of novel coding sequences by reporting on smORF translation. In Ribo-Seq, ribosome-protected footprints (RPFs) that map to multiple genomic sites are removed since they cannot be unambiguou… Show more
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