Rp-Hplc Method for Simultaneous Determination of Tolperisone Hcl and Diclofenac Sodium in Pharmaceutical Dosage Form

Gandla, Kumaraswamy; Swapna, V.; Kumar, Dhiraj

doi:10.15226/2374-6866/4/3/00162

Cited by 3 publications

(2 citation statements)

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“…The contents in the beaker and the Petri plate were washed using ethanol or water depending on the API solubility. The APIs were analyzed by a suitable HPLC method after minor modifications. − …”

Section: Experimental Methodsmentioning

confidence: 99%

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Sublimation of Drugs from the Site of Application of Topical Products

Murthy¹,

Echanur²,

Matadh³

et al. 2023

Mol. Pharmaceutics

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The objective of the project was to investigate the plausibility of active pharmaceutical ingredients (APIs) to undergo sublimation from topical application following evaporation of solvent. Topical formulations with different APIs were subjected to a sublimation screening test. The APIs in the selected topical products were found to undergo sublimation to a different extent. The salicylic acid topical product was found to undergo a significant loss due to sublimation. The extent of sublimation of salicylic acid was significantly greater at skin temperature compared to room temperature. When the APIs were subjected to the sublimation screening test in their neat form at 32 ± 1 °C, the natural log of the rate of sublimation decreased linearly with the standard enthalpy of sublimation of compound (R 2 = 0.89). The formulation composition was found to have a significant impact on the extent of sublimation of the representative API, salicylic acid. The sublimation of APIs from the topical product was found to affect the mass balance studies in the case of the salicylic acid ointment. Furthermore, the results of the human studies agreed with the in vitro experimental results demonstrating the plausibility of loss of API due to sublimation from the site of application.

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Section: Experimental Methodsmentioning

confidence: 99%

“…The analysis was performed using a Shimadzu SPD-20 A HPLC system (Japan) using UV detection. The method of analysis including the column details, composition of the mobile phase, and pH are described in Table . − …”

Section: Methodsmentioning

confidence: 99%