RP-HPLC Determination of Phenylalkanoids and Terpenoids in Rhodiola rosea and Identification by LC-MSD-TOF

Avula, Bharathi; Wang, Y. H.; Ali, Zulfiqar; Smillie, Troy J.; Filion, Vicky; Cuerrier, Alain; Arnason, J. T.; Khan, I. A.

doi:10.1055/s-2008-1075331

Cited by 3 publications

(3 citation statements)

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“…A simple, rapid and sensitive method was developed to determine salidroside in R. rosea Fuqu and R. rosea soy sauce using high-performance liquid chromatographyelectrospray tandem mass spectrometry (HPLC-ESI-MS/MS). Many analytical methods have been used to determine salidroside in herbs, pharmaceuticals and biological samples, such as highperformance capillary zone electrophoresis (15), thin-layer chromatography (16), HPLC (17), colorimetric methods (18), gas chromatography (19), HPLC-MS (20), and HPLC-MS/MS (21). However, no method has been published for the determination of salidroside in Fuqu and soy sauce.…”

Section: Introductionmentioning

confidence: 99%

Development of theRhodiola rosea FuquandRhodiola roseasoy sauce, and the determination of their functional properties

Gao

Zhang

et al. 2016

J. Inst. Brew.

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A mixed starter, composed of high‐quality Rhodiola rosea Fuqu, was developed. Compared with normal Fuqu, Rhodiola rosea Fuqu demonstrated higher spore numbers, spore germination rates, protease activity, liquefying amylase activity and total acid and amino acid nitrogen. Specifically, the spore number was 1.36 times that of regular Fuqu. Protease activity, liquefying amylase activity, total acid and amino acid nitrogen were 0.475 g/100 mL, 104.16 U/g dry Qu, 35.67 mmol/L and 26.08 g/100 mL, respectively. These values were 21.48, 7.41, 6.07 and 67.82% higher than the regular Fuqu. The Rhodiola rosea soy sauce indices were also better than those for the control. The DPPH scavenging abilities of R. rosea soy sauce, control soy sauce, market soy sauce 1 and market soy sauce 2 were 74.25, 44.01, 34.73 and 11.38%, respectively. The total phenolic content in these four samples was 387.38, 309.23, 212.85 and 202.60 mg GAE/g, respectively. As observed with the DPPH and total phenolic assay, the R. rosea soy sauce showed the highest antioxidant capacity. A simple, rapid, and sensitive determination method of salidroside in R. rosea Fuqu and R. rosea soy sauce using HPLC‐ESI‐MS/MS was developed and validated with multiple reaction monitoring in the negative mode.

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Section: Introductionmentioning

confidence: 99%

Development of theRhodiola rosea FuquandRhodiola roseasoy sauce, and the determination of their functional properties

Gao

Zhang

et al. 2016

J. Inst. Brew.

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“…The components that have been reported as pharmacologically active are salidroside and the rosavins (rosavin, rosarin and rosin), which are exclusive to R. rosea roots, whereas salidroside is not. Rhodiola rosea products are standardised according to salidroside and rosavins contents, although there is increasing interest to monitor other components present in these extracts for quality and authenticity control (Ganzera et al, 2001;Avula et al, 2009;Ma et al, 2011). At present, the rosavins and salidroside can be purchased commercially, but they are relatively expensive for low milligram quantities and may not be readily available when purchased.…”

Section: Introductionmentioning

confidence: 99%

Purification of Phenylalkanoids and Monoterpene Glycosides from Rhodiola rosea L. Roots by High‐speed Counter‐current Chromatography

Mudge

Lopes‐Lutz

Brown

et al. 2012

Phytochemical Analysis

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“…Adaptogens are natural substances that are used to achieve optimal mental, physical, and work performance by increasing nonspecific resistance to physical, chemical, and biological stress [Brekhman and Dardymov, 1969;Carlini, 2003;Panossian and Wagner, 2005;Wiegant et al, 2009]. Phytochemical constituents from the Rhodiola gender are speciesdependent [Kurkin and Zapesochnaya, 1986;Yousef et al, 2006;Avula et al, 2009]. Approximately 140 compounds have been isolated from the root and rhizome of R. rosea.…”

Section: Introductionmentioning

confidence: 99%

Neuropharmacological and Toxicity Evaluations of Ethanol Extract from RhodiolaRosea

Montiel-Ruiz

Roa-Coria

Patiño-Camacho

et al. 2012

Drug Development Research

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Strategy, Management and Health PolicyEnabling Technology, Genomics, ProteomicsPreclinical ResearchPreclinical Development Toxicology, Formulation Drug Delivery, PharmacokineticsClinical Development Phases I‐III Regulatory, Quality, ManufacturingPostmarketing Phase IV Rhodiola rosea is a popular medicinal plant that is commonly used as an adaptogen in folklore medicine in Europe and Asia due to its ability to increase an organism's resistance to physical, chemical and biological stress. The aim of this study was to determine the central nervous system activity and toxicity parameters of R. rosea. An ethanol extract from the roots of R. rosea was orally (p.o.) administered to mice (10–316 mg/kg); exploratory activity, anti‐anxiety, behavior, sodium pentobarbital‐induced hypnosis, antinociceptive effects, and pentylenetetrazole‐induced seizures were tested. The results from the experimental models tested showed a significant reduction in exploratory behavior and in the number of rearings and head dippings, but no change in the sedative‐hypnotic and anticonvulsant response with respect to vehicle. Moreover, R. rosea reduced the licking time in the formalin test. R. rosea was not toxic in Artemia salina and in mice. The present results confirm some preclinical and clinical studies that indicate stimulating, anxiolytic‐like effects and present new evidence of the antinociceptive effect of and very low risk of toxicity from R. rosea.

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RP-HPLC Determination of Phenylalkanoids and Terpenoids in Rhodiola rosea and Identification by LC-MSD-TOF

Cited by 3 publications

References 0 publications

Development of theRhodiola rosea FuquandRhodiola roseasoy sauce, and the determination of their functional properties

Development of theRhodiola rosea FuquandRhodiola roseasoy sauce, and the determination of their functional properties

Purification of Phenylalkanoids and Monoterpene Glycosides from Rhodiola rosea L. Roots by High‐speed Counter‐current Chromatography

Neuropharmacological and Toxicity Evaluations of Ethanol Extract from RhodiolaRosea

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