Różne oblicza mitochondrialnego koenzymu Q

Dominiak, Karolina; Jarmuszkiewicz, Wiesława

doi:10.18388/pb.2019_289

Cited by 4 publications

(3 citation statements)

References 34 publications

(43 reference statements)

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“…В литературе имеются достаточно неоднозначные данные о влиянии статинов на энергетический обмен в органах-мишенях. В обзоре, представленном Broniarek I., Jarmuszkiewicz W. (2016), приводятся данные, что токсическое действие на митохондрии оказывают симвастатин и ловастатин (гидрофобные статины), тогда как аторвастатин и правастатин (гидрофильные статины) такими эффектами не обладают [17]. В тоже время Лакомкин В.Л.…”

Section: Discussionunclassified

Comparative analysis of metabolic and structural changes in the skeletal muscles and myocardium of rats on the background of long-term administration of simvastatin

Белоусова

Микашинович

Vinogradova

et al. 2023

jour

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Objective: to conduct a comparative analysis of the dynamics of changes in the end products of glycolysis and the isoform composition of the giant protein - titin and nebulin in the skeletal and cardiac muscles of animals with HC during long-term administration of simvastatin. Materials and methods: the study was conducted on rats that were kept on a high-fat and high-carbohydrate diet for three months. After GC confirmation, the animals were divided into groups: group 1 received only the experimental diet; group 2 received simvastatin in the form of an aqueous suspension for two months at the rate of 0.012 g/kg of animal weight once a day. The control group of animals was kept on the general diet of the vivarium. Results: The formation of HCh was accompanied by the accumulation of pyruvate and lactic acid both in the myocardium and in muscle tissue. The revealed metabolic changes reflect structural disorders and indicate the formation of hypoxia. Against the background of the introduction of simvastatin, both in the myocardium and in the skeletal muscles, a decrease in the level of pyruvate and lactic acid was noted and these indicators approached the values of the control group. Such changes reflect a tendency to restore the integration of intracellular metabolic processes. However, in the study of titin and nebulin proteins against the background of the use of simvastatin, both in the myocardium and in skeletal muscles, structural changes were noted: accumulation of the proteolytic T-fragment, a decrease in the content of intact titin isoforms. Also, statin-induced structural abnormalities have been identified in earlier studies of rat muscle biopsies. Conclusion: The conducted comparative study clearly demonstrates that the myocardium, along with skeletal muscles, is the target organ of the toxic effect of statins. Based on this, the data obtained as a result of the study, it is important to take into account the pharmacotherapy with statins.

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Section: Discussionunclassified

Comparative analysis of metabolic and structural changes in the skeletal muscles and myocardium of rats on the background of long-term administration of simvastatin

Белоусова

Микашинович

Vinogradova

et al. 2023

jour

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“…Statins, also known as HMG-CoA reductase inhibitors, work by inhibiting the mevalonate pathway by blocking the conversion of HMG-CoA to mevalonic acid, which is a rate-limiting step in cholesterol synthesis [ 118 ]. The final metabolites of the mevalonate pathway, farnesyl and geranyl, are substrates for the isoprenylation of Ras proteins [ 119 ].…”

Section: Isoprenylationmentioning

confidence: 99%

Role of non-canonical post-translational modifications in gastrointestinal tumors

Liu,

Peng

et al. 2023

Cancer Cell Int

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Post-translational modifications (PTMs) of proteins contribute to the occurrence and development of tumors. Previous studies have suggested that canonical PTMs such as ubiquitination, glycosylation, and phosphorylation are closely implicated in different aspects of gastrointestinal tumors. Recently, emerging evidence showed that non-canonical PTMs play an essential role in the carcinogenesis, metastasis and treatment of gastrointestinal tumors. Therefore, we summarized recent advances in sumoylation, neddylation, isoprenylation, succinylation and other non-canonical PTMs in gastrointestinal tumors, which comprehensively describe the mechanisms and functions of non-classical PTMs in gastrointestinal tumors. It is anticipated that targeting specific PTMs could benefit the treatment as well as improve the prognosis of gastrointestinal tumors.

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“…βcarotene shows the ability to remove singlet oxygen and lipid peroxides [1,22]; • flavonoids and anthocyanins occur in plants such as: mountain arnica, chamomile, liquorice, ginkgo, hops, green and black tea, they have the ability to scavenge free radicals, protect against lipid oxidation and have antiin flammatory and antimutagenic properties [23]; • coenzyme Q10 -is a fat-soluble antioxidant, binds free radicals and inhibits lipid peroxidation processes and prevents oxidative modifications of DNA and proteins. Moreover, it has the ability to regenerate vitamin E [24]; • glutathione -a water-soluble cysteine-containing tripep tide commonly found in all plant and animal eukaryotic cells. It is highly concentrated in the liver.…”

Section: Non-enzymatic Antioxidantsmentioning

confidence: 99%

Antioxidants as a defence against reactive oxygen species

Marwicka¹,

Zięba²

2021

Aesth Cosmetol Med

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Reactive oxygen species are formed as a natural product of metabolic processes occurring in the organism or under the influence of external factors. Under homeostasis, they play an important role as a cellular signaling device. During oxidative stress, when they are produced in excess, they can cause damages to proteins, lipids, carbohydrates or nucleic acids. Exposure of cells and extracellular structures to free radicals activate natural mechanisms to eliminate free radicals and their derivatives. The aim of the article was to present what antioxidants are, and how they protect cells against the free radicals. The protective system against the free radicals consists of antioxidant enzymes: superoxide dismutase, catalase, glutathione peroxidases, and reductase. Low-molecular antioxidants such as vitamin C, E, carotenoids, coenzyme Q10, flavonoids, glutathione and melatonin also play an important role.

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Różne oblicza mitochondrialnego koenzymu Q

Cited by 4 publications

References 34 publications

Comparative analysis of metabolic and structural changes in the skeletal muscles and myocardium of rats on the background of long-term administration of simvastatin

Comparative analysis of metabolic and structural changes in the skeletal muscles and myocardium of rats on the background of long-term administration of simvastatin

Role of non-canonical post-translational modifications in gastrointestinal tumors

Antioxidants as a defence against reactive oxygen species

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