Royal jelly reduce DNA damage induced by alkylating agent in mice

Damiani, Adriani Paganini; Magenis, Marina Lummertz; Dagostin, Ligia Salvan; Beretta, Ângela; Sarter, Rovena Jacobsen; Longaretti, Luiza Martins; Monteiro, Isadora de Oliveira; Andrade, Vanessa Moraes de

doi:10.1016/j.mrfmmm.2022.111796

Cited by 4 publications

(4 citation statements)

References 43 publications

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“…In rats, the administration of Egyptian royal jelly at 100 and 250 mg/kg body weight for 5 days did not induce DNA damage in liver cells [ 45 ]. In addition, the peripheral blood cells of mice treated for 24 and 48 h with commercial royal jelly at 150, 300, and 1000 mg/kg did not show significant differences in DNA damage when compared to the control with untreated mice [ 24 ].…”

Section: Resultsmentioning

confidence: 99%

“…Recent studies have shown the protective effect of honey and other bee products on induced DNA damage [ 22 , 23 , 24 ]. Stingless bee honey has been used by traditional medicine practitioners for many years and has recently shown protective effects against hydrogen peroxide (H 2 O 2 )-induced cell death and DNA damage in human lymphoblastoid cells [ 23 ].…”

Section: Introductionmentioning

confidence: 99%

“…Propolis is also able to protect induced oxidative DNA damage in human liver cells through reactive oxygen species (ROS) scavenging [ 22 ]. In addition, royal jelly has presented antigenotoxic and antimutagenic properties in vivo in mice treated with methyl methanesulfonate [ 24 ]. However, there is limited information regarding the effect of monofloral honey samples and their combination with propolis and royal jelly on DNA damage.…”

Section: Introductionmentioning

confidence: 99%

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Protective Effect of Thyme and Chestnut Honeys Enriched with Bee Products against Benzo(a)pyrene-Induced DNA Damage

Sánchez-Martín

Haza

Iriondo‐DeHond

et al. 2022

IJERPH

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The aim of the present study was to validate the cytotoxicity, genotoxicity, and preventive potential against benzo(a)pyrene (BaP)-induced DNA damage of nine samples of thyme and chestnut honeys enriched with bee products (royal jelly and propolis, 2–10%). Cell viability was determined by the MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] assay (0–250 mg/mL) to select nontoxic concentrations, and DNA damage (0.1–10 μg/mL) was evaluated by the alkaline single-cell gel electrophoresis or comet assay. Treatment with honey samples or royal jelly and propolis did not affect the viability of HepG2 cells up to 100 and 50 mg/mL, respectively. Treatment with 100 μM BaP significantly increased (p ≤ 0.001) the levels of the DNA strand breaks. None of the tested concentrations (0.1–10 μg/mL) of the honey samples (thyme and chestnut), royal jelly, and propolis caused DNA damage per se. All tested samples at all the concentrations used decreased the genotoxic effect of BaP. In addition, all mixtures of thyme or chestnut honeys with royal jelly or propolis showed a greater protective effect against BaP than the samples alone, being the thyme and chestnut honey samples enriched with 10% royal jelly and 10% propolis the most effective (70.4% and 69.4%, respectively). The observed protective effect may be associated with the phenolic content and antioxidant capacity of the studied samples. In conclusion, the thyme and chestnut honey samples enriched with bee products present potential as natural chemoprotective agents against the chemical carcinogen BaP.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Protective Effect of Thyme and Chestnut Honeys Enriched with Bee Products against Benzo(a)pyrene-Induced DNA Damage

Sánchez-Martín

Haza

Iriondo‐DeHond

et al. 2022

IJERPH

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“…In the adult male Sprague–Dawley rats, exposure of the whole body to irradiation induced prominent liver failure, characterized by a marked increase in serum AST, ALT, cholesterol, and triglyceride levels, and with the increased production of MDA and reduced levels of GPx, CAT and SOD in the lung and liver tissue. Pre- and post-treatment with RJ markedly decreased the oxidative stress parameters and ameliorated changes of biochemical parameters, increasing the antioxidant activities [ 249 , 278 ]. The authors suggested that the protective effect of RJ in irradiated animals may be due to the improved activity of endogenous antioxidants, the free radical scavenging activity of RJ, and decreased lipid peroxidation.…”

Section: Biological Function Of Royal Jellymentioning

confidence: 99%

Royal Jelly: Biological Action and Health Benefits

Oršolić,

Jazvinšćak Jembrek

2024

IJMS

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Royal jelly (RJ) is a highly nutritious natural product with great potential for use in medicine, cosmetics, and as a health-promoting food. This bee product is a mixture of important compounds, such as proteins, vitamins, lipids, minerals, hormones, neurotransmitters, flavonoids, and polyphenols, that underlie the remarkable biological and therapeutic activities of RJ. Various bioactive molecules like 10-hydroxy-2-decenoic acid (10-HDA), antibacterial protein, apisin, the major royal jelly proteins, and specific peptides such as apisimin, royalisin, royalactin, apidaecin, defensin-1, and jelleins are characteristic ingredients of RJ. RJ shows numerous physiological and pharmacological properties, including vasodilatory, hypotensive, antihypercholesterolaemic, antidiabetic, immunomodulatory, anti-inflammatory, antioxidant, anti-aging, neuroprotective, antimicrobial, estrogenic, anti-allergic, anti-osteoporotic, and anti-tumor effects. Moreover, RJ may reduce menopause symptoms and improve the health of the reproductive system, liver, and kidneys, and promote wound healing. This article provides an overview of the molecular mechanisms underlying the beneficial effects of RJ in various diseases, aging, and aging-related complications, with special emphasis on the bioactive components of RJ and their health-promoting properties. The data presented should be an incentive for future clinical studies that hopefully will advance our knowledge about the therapeutic potential of RJ and facilitate the development of novel RJ-based therapeutic opportunities for improving human health and well-being.

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