Royal jelly may improve the metabolism of glucose and redox state of ovine oocytes matured in vitro and embryonic development following in vitro fertilization

Eshtiyaghi, Mahbobeh; Deldar, Hamid; Pirsaraei, Zarbakht Ansari; Shohreh, Bahram

doi:10.1016/j.theriogenology.2016.07.019

Cited by 25 publications

(29 citation statements)

References 56 publications

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“…The investigation of protective effect of royal jelly in the redox state of ovine oocytes matured in vitro , and embryonic development following in vitro fertilization was performed by Eshtiyaghi et al [ 132 ]. The authors explained that the improvement of oocyte maturation in the case of cells supplemented with royal jelly might be associated with the improvement of redox status.…”

Section: Royal Jellymentioning

confidence: 99%

Antioxidant Potential of Propolis, Bee Pollen, and Royal Jelly: Possible Medical Application

Kocot

Kiełczykowska

Luchowska-Kocot

et al. 2018

Oxidative Medicine and Cellular Longevity

347

358

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Honeybees products comprise of numerous substances, including propolis, bee pollen, and royal jelly, which have long been known for their medicinal and health-promoting properties. Their wide biological effects have been known and used since antiquity. Bee products are considered to be a potential source of natural antioxidants such as flavonoids, phenolic acids, or terpenoids. Nowadays, the still growing concern in natural substances capable of counteracting the effects of oxidative stress underlying the pathogenesis of numerous diseases, such as neurodegenerative disorders, cancer, diabetes, and atherosclerosis, as well as negative effects of different harmful factors and drugs, is being observed. Having regarded the importance of acquiring drugs from natural sources, this review is aimed at updating the current state of knowledge of antioxidant capacity of selected bee products, namely, propolis, bee pollen, and royal jelly, and of their potential antioxidant-related therapeutic applications. Moreover, the particular attention has been attributed to the understanding of the mechanisms underlying antioxidant properties of bee products. The influence of bee species, plant origin, geographic location, and seasonality as well as type of extraction solutions on the composition of bee products extracts were also discussed.

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Section: Royal Jellymentioning

confidence: 99%

Antioxidant Potential of Propolis, Bee Pollen, and Royal Jelly: Possible Medical Application

Kocot

Kiełczykowska

Luchowska-Kocot

et al. 2018

Oxidative Medicine and Cellular Longevity

347

358

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“…In this study, 10.0 mg/mL of royal jelly showed better rates of development of oocytes (85.6%) and embryos (39.6%), increased expression of antioxidant enzyme genes (superoxide dismutase, catalase and glutathione peroxidase) in cumulus cells and increased intracellular GSH levels (ESHTIYAGHI et al, 2016).…”

Section: Essential Oils and Extractsmentioning

confidence: 53%

“…Another employed technique is the analysis of gene expression, especially of enzymes involved in the cellular antioxidant system such as catalase, superoxide dismutase, and glutathione peroxidase, and genes related to apoptotic pathways (ESHTIYAGHI et al, 2016;MESALAM et al, 2017). Moreover, quantification of ROS levels using a fluorescent marker (2′, 7′-dichlorodihydrofluorescein diacetate) allows specific evaluation of the antioxidant ability to reduce intracellular ROS (AMBROGI et al, 2017).…”

Section: Methods For Evaluation Of Antioxidants In Ivepmentioning

confidence: 99%

“…In general, extracts and essential oils are rich in phenolic compounds, carotenoids, terpenes, and other organic substances that have varied therapeutic properties (PEREIRA et al, 2012b) such as antioxidant activity (ESHTIYAGHI et al, 2016). Some of these compounds have also been studied in IVEP as antioxidants though they were not purified and of variable composition.…”

Section: Essential Oils and Extractsmentioning

confidence: 99%

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Use of natural antioxidants in in vitro mammalian embryo production

Santos

Borges

Neta

et al. 2018

SCA

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In vitro embryo production (IVEP) contributes to the quantitative and qualitative aspects of animal reproduction. Nevertheless, inherent technical factors such as oxidative stress can negatively influence the result and this can impair cell metabolism, thus decreasing the rates of in vitro development, and necessitating the supplementation of culture medium with antioxidants. In this context, compounds of natural origin with this property have been highlighted because of the positive results obtained at different stages of IVEP. Thus, this review aims to present the results obtained by using natural antioxidants to minimize the effects of oxidative stress on gametes and embryos. A variety of natural isolated substances and mixtures (essential oils and extracts) have been studied for supplementation of IVEP media, at stages of in vitro maturation, sperm capacitation, in vitro fertilization, and in vitro development of embryos in different mammalian species. Generally, beneficial effects are observed according to the concentration used, thus demonstrating the potential of several natural antioxidants. Therefore, the main challenges in using these compounds as antioxidants during IVEP include proving their efficiency against free radicals and determining the best concentration at each stage. In addition, understanding the mechanisms of action of such antioxidants is crucial to establishing their use in IVEP biotechnology. Key words: Culture medium. Natural bioactive. Oxidative stress. Reproduction. ResumoA produção in vitro de embriões (PIVE) contribui para os aspectos quantitativos e qualitativos da reprodução animal. Contudo, fatores inerentes da técnica, como o estresse oxidativo, podem influenciar negativamente o resultado e isso pode prejudicar o metabolismo celular, diminuindo assim as taxas de desenvolvimento in vitro, e exigindo a suplementação do meio de cultivo com antioxidantes. Neste contexto, os compostos de origem natural com essa propriedade têm se destacado devido aos resultados positivos obtidos em diferentes estágios da PIVE. Assim, esta revisão pretende apresentar os resultados obtidos usando antioxidantes naturais para minimizar os efeitos do estresse oxidativo em gametas e embriões. Uma variedade de substâncias isoladas e de misturas naturais (óleos essenciais e extratos) tem sido estudada para a suplementação de meios de PIVE, nas etapas de maturação in vitro, capacitação espermática, fecundação in vitro e desenvolvimento in vitro de embriões em diferentes espécies de mamíferos. Geralmente, os efeitos benéficos são observados de acordo com a concentração utilizada,

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“…RJ administration could improve the in vitro fertilization capacity of Nili-Ravi buffalo bull sperm and post-thaw quality [179]. RJ treatment may induce higher levels of oocyte maturation, fertilization, and blastocyst formation by enhancing the activity of glycolysis, pentose phosphate pathway, and antioxidant enzyme activity in oocyte and cumulus cell [180]. The administration of RJ endorses follicular growth and ovarian hormones in immature female rats through its estrogenic effects on the reproductive system to improve the fertility parameters [181].…”

Section: Estrogenic Effectmentioning

confidence: 99%

New Insights into the Biological and Pharmaceutical Properties of Royal Jelly

Ahmad

Campos

Fratini

et al. 2020

IJMS

157

134

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Royal jelly (RJ) is a yellowish-white and acidic secretion of hypopharyngeal and mandibular glands of nurse bees used to feed young worker larvae during the first three days and the entire life of queen bees. RJ is one of the most appreciated and valued natural product which has been mainly used in traditional medicines, health foods, and cosmetics for a long time in different parts of the world. It is also the most studied bee product, aimed at unravelling its bioactivities, such as antimicrobial, antioxidant, anti-aging, immunomodulatory, and general tonic action against laboratory animals, microbial organisms, farm animals, and clinical trials. It is commonly used to supplement various diseases, including cancer, diabetes, cardiovascular, and Alzheimer’s disease. Here, we highlight the recent research advances on the main bioactive compounds of RJ, such as proteins, peptides, fatty acids, and phenolics, for a comprehensive understanding of the biochemistry, biological, and pharmaceutical responses to human health promotion and life benefits. This is potentially important to gain novel insight into the biological and pharmaceutical properties of RJ.

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Royal jelly may improve the metabolism of glucose and redox state of ovine oocytes matured in vitro and embryonic development following in vitro fertilization

Cited by 25 publications

References 56 publications

Antioxidant Potential of Propolis, Bee Pollen, and Royal Jelly: Possible Medical Application

Antioxidant Potential of Propolis, Bee Pollen, and Royal Jelly: Possible Medical Application

Use of natural antioxidants in in vitro mammalian embryo production

New Insights into the Biological and Pharmaceutical Properties of Royal Jelly

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