Royal jelly is an effective and relatively safe alternative approach to blood lipid modulation: A meta-analysis

Hadi, Amir; Najafgholizadeh, Ameneh; Aydenlu, Elham Smadi; Shafiei, Zahra; Pirivand, Fatemeh; Golpour, Sahar; Pourmasoumi, Makan

doi:10.1016/j.jff.2017.12.005

Cited by 36 publications

(26 citation statements)

References 35 publications

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“…In studies where net changes were not directly reported in the intervention and control groups, the effect size was computed by subtracting the values at the endpoint of the intervention from those at baseline. The standard deviations of mean differences were calculated by using SD = square root ((SD pretreatment)2 + (SD posttreatment)2 − (2R × SD pretreatment × SD posttreatment)), with the correlation coefficient (R) assumed to be 0.5 [49,50]. Effect size (ES) and its 95% confidence interval (CI) were calculated utilizing Cohen's method, reflecting the standardized difference in means (SDM) between measured parameters (i.e., TMT-A, TMT-B, BDNF, Hs-CRP, IL-6, and TNF-α), both in response to (poly)phenol-rich supplementation and to placebo.…”

Section: Discussionmentioning

confidence: 99%

The Effect of (Poly)phenol-Rich Interventions on Cognitive Functions and Neuroprotective Measures in Healthy Aging Adults: A Systematic Review and Meta-Analysis

Ammar

Trabelsi

Müller

et al. 2020

JCM

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Context: As the food industry is continually involved in the development of new attractive alternative therapeutic agents, the evaluation of the beneficial impact of (poly)phenols on cognitive and brain function during aging has gained increasing interest. Objective: This systematic review and meta-analysis aimed to evaluate the acute and chronic effects of (poly)phenol-rich diet supplementation on cognitive function and brain health in aging adults. Data Sources: PubMed and Web of Science databases were searched for relevant randomized placebo-controlled trials (RCTs) published from inception to July 2019. Study Selection: Two researchers independently screened 4303 records, using the PICOS criteria: Participants were aging adults; Intervention was based on acute and/or chronic (poly)phenols-rich supplementation; Comparator was any comparator; Outcomes included cognitive function and neuroprotective measures; and Study design was RCTs. A third researcher was consulted when discrepancies arose. Fifteen high-quality (mean PEDro score = 8.8 ± 0.56) RCTs (total participants: 918 healthy older adults) were included in the final sample. Data Extraction: Information on study design, employed treatment, characteristics of participants, outcomes, and the correspondent assessing methods were extracted. Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed. Data Analysis and Results: A random-effects meta-analysis was used to pool estimates across studies. Effect size (ES) and its 95% confidence interval (CI) was calculated. Pooled results yielded a trivial ES (−0.2 to 0.03) for brain-derived neurotrophic factor and neuroinflammatory parameters and small (0.36) to moderate (0.82) ES for executive functions. Conclusion: This meta-analysis failed to provide evidence regarding the neuroprotective and anti-inflammatory effect of (poly)phenols supplementation in aging adults. However, findings from individual studies, included in this systematic review, suggest polyphenol-rich supplementation may improve some cognitive and brain functions in older adults. The beneficial effect of polyphenols seems to depend on ingested dose and bioavailability. Results suggest at least an intermediate dose (≥500 mg), and intermediate (≈9%) to high (43%) bioavailability rates are needed to cross the brain blood barrier and to exert a significant effect on cognitive health.

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Section: Discussionmentioning

confidence: 99%

The Effect of (Poly)phenol-Rich Interventions on Cognitive Functions and Neuroprotective Measures in Healthy Aging Adults: A Systematic Review and Meta-Analysis

Ammar

Trabelsi

Müller

et al. 2020

JCM

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“…As knowledge about the mechanisms of NAFLD pathogenesis is growing, researchers are aiming to find effective therapeutic agents across pharmacology, nutrition, and complementary fields (Kanai et al, ; Trovato, Catalano, Martines, Pace, & Trovato, ; Zhang et al, ). Although the evidences showed that herbal remedies are generally better tolerated than synthetic medications (Izzo, Hoon‐Kim, Radhakrishnan, & Williamson, ), there is a lack of conclusive information in efficacy and their possible side effect on diseases, and this issue made it one of the important problems faced by doctors (Hadi et al, ). In this case, a comprehensive systematic review of available clinical trials can represent the most reliable evidence of medicinal plant efficacy (Izzo et al, ).…”

Section: Discussionmentioning

confidence: 99%

Green tea as a safe alternative approach for nonalcoholic fatty liver treatment: A systematic review and meta‐analysis of clinical trials

Mansour-Ghanaei

Hadi

Pourmasoumi

et al. 2018

Phytotherapy Research

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This study aimed to evaluate the efficacy of green tea supplementation on nonalcoholic fatty liver disease treatment. Electronic databases, including PubMed, Scopus, Web of Science, and Google Scholar, were systematically searched up to October 30, 2017, to identify eligible trials based on the inclusion criteria. The effect size was presented as mean difference with 95% confidence intervals (CI). The meta-analysis of data from four studies indicated significant effects of green tea supplementation in altering alanine aminotransferases (-12.81 U/L; 95% CI: -18.17 to -7.45) and aspartate aminotransferases (-10.91 U/L; 95% CI: -19.66 to -2.17) blood concentrations. Likewise, a favorable effect of green tea administration was observed on body mass index (-2.08 kg/cm ; 95% CI: -2.81 to -1.36), triacylglycerol (-31.87 mg/dl; 95% CI: -40.62 to -23.12), total cholesterol (-27.57 mg/dl; 95% CI: -36.17 to -18.98), and low-density lipoprotein cholesterol (-14.15 mg/dl; 95% CI: -23.69 to -4.60), whereas no significant effect was detected on high-density lipoprotein cholesterol concentrations (7.41 mg/dl; 95% CI: -1.49 to 16.30) and homeostasis model assessment of insulin resistance (-4.06; 95% CI: -10.22 to 2.09). This systematic review and meta-analysis of available trials suggests that there are potential benefits of green tea supplementation on nonalcoholic fatty liver disease.

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“…Nowadays, complementary and alternative medicine is widely applied alongside the methods mentioned (Pourmasoumi et al, ; Vishnu, Mini, & Thankappan, ). In this context, the complementary use of apitherapy—the medical use of honey bee products (royal jelly, propolis, bee venom, pollen, and honey)—for the treatment of diseases is increasing globally (Farooqui & Farooqui, ; Hadi et al, ). These products are easily available and free from serious adverse effects, making honey bee products a popular choice (Sforcin, Bankova, & Kuropatnicki, ).…”

Section: Introductionmentioning

confidence: 99%

The efficacy of propolis on markers of glycemic control in adults with type 2 diabetes mellitus: A systematic review and meta‐analysis

Karimian

Hadi

Pourmasoumi

et al. 2019

Phytotherapy Research

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Background and Objectives The impetus for the current study was to evaluate the efficacy of propolis supplementation on markers of glycemic status in adults with type 2 diabetes mellitus (T2DM). Methods A comprehensive search was conducted in PubMed, Scopus, Cochrane Library, Web of Science, and Google Scholar up to August 2018, identifying randomized controlled trials investigating the effect of propolis supplementation on glycemic markers in adults with T2DM. Cochrane Collaboration tool was used to evaluate the risk of bias assessment. A random‐effects model was applied in the meta‐analysis to compensate for potential heterogeneity among the included studies. Results Six randomized controlled trials comprising 373 participants were included in the systematic review and meta‐analysis. The results of the meta‐analysis revealed significant reductions in fasting plasma glucose (−13.51 mg/dl; 95% CI [−24.98, −2.04]) and hemoglobin A1C (−0.52%; 95% CI [−0.94, −0.10]) concentrations following propolis supplementation. However, no significant lowering effect was observed in fasting insulin levels (−0.53 pmol/L; 95% CI [−1.69, 0.63]) or homeostasis model assessment of insulin resistance (−0.543; 95% CI [−1.72, 0.64]). Conclusion This systematic review and meta‐analysis suggested that propolis supplementation may be effective in controlling glycemic levels for T2DM patients. Further studies are needed to confirm these results.

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Royal jelly is an effective and relatively safe alternative approach to blood lipid modulation: A meta-analysis

Cited by 36 publications

References 35 publications

The Effect of (Poly)phenol-Rich Interventions on Cognitive Functions and Neuroprotective Measures in Healthy Aging Adults: A Systematic Review and Meta-Analysis

The Effect of (Poly)phenol-Rich Interventions on Cognitive Functions and Neuroprotective Measures in Healthy Aging Adults: A Systematic Review and Meta-Analysis

Green tea as a safe alternative approach for nonalcoholic fatty liver treatment: A systematic review and meta‐analysis of clinical trials

The efficacy of propolis on markers of glycemic control in adults with type 2 diabetes mellitus: A systematic review and meta‐analysis

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