Royal jelly increases peripheral circulation by inducing vasorelaxation through nitric oxide production under healthy conditions

Liang, Yaoyue; Kagota, Satomi; Maruyama, Kana; Oonishi, Yuri; Miyauchi-Wakuda, Shino; Ito, Yoshihiko; Yamada, Shizuo; Shinozuka, Kazumasa

doi:10.1016/j.biopha.2018.07.047

Cited by 12 publications

(9 citation statements)

References 30 publications

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“…However, the changes in the number of EPCs throughout the intervention were similar between them (Table 4). Several peptides in RJ inhibit ACE activity and RJ induces vasorelaxation through nitric oxide production from the vascular endothelium related to improvement of blood pressure in hypertensive rodents and humans, previously reported [38][39][40][41]. On the other hand, RJ consumption did not alter blood pressure in healthy human subjects, although it improved vascular endothelial function as assessed using RH-PAT [10].…”

Section: Discussionmentioning

confidence: 92%

Royal Jelly Increases Hematopoietic Stem Cells in Peripheral Blood: A Double‐Blind, Placebo‐Controlled, Randomized Trial in Healthy Subjects

Okamoto¹,

Ohkuma²,

Kawaguchi³

et al. 2023

Evidence-Based Complementary and Alternative Medicine

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Objectives. Royal jelly (RJ), produced by honeybees, influences stem cell functions, such as pluripotency maintenance of mouse embryonic stem cells and prevention of aging-related muscle stem cell functional deterioration. Thus, we hypothesized that RJ administration has various health-promoting effects based on stem cells. However, its effects are unknown in humans. In this study, we have attempted for the first time to clarify whether the administration of RJ in humans affects stem cells. Materials and Methods. This randomized, double-blind, placebo-controlled study was performed on healthy subjects (n = 90) who received protease-treated RJ at a dose of 1200 mg/day or placebo daily for four weeks. Also, the participants with a low number of hematopoietic stem cells (HSCs) in peripheral blood were preferentially selected. HSC counts, endothelial progenitor cell (EPC) counts, blood cell counts in peripheral blood, cytokines in serum, and physical conditions were evaluated. Results and Conclusion. Eligible data from 86 subjects (placebo: 42, RJ: 44) who completed the study were analyzed. There were no significant differences between the two groups regarding the changes in peripheral HSC count ( p = 0.103 ), while diastolic blood pressure showed a significant improvement in the RJ group compared to that in the placebo group ( p = 0.032 ). The subgroup analysis excluded 14 subjects who complained of cold symptoms at baseline or within five days of the four-week study. The changes in the HSC populations were significantly higher in the RJ group than those in the placebo group ( p = 0.042 ). No adverse effects were observed in any of the groups. These results suggest that RJ administration affected the peripheral HSC count and may influence stem cell functions. Further research is needed to reveal the various health-promoting benefits of RJ based on stem cells.

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Section: Discussionmentioning

confidence: 92%

Royal Jelly Increases Hematopoietic Stem Cells in Peripheral Blood: A Double‐Blind, Placebo‐Controlled, Randomized Trial in Healthy Subjects

Okamoto¹,

Ohkuma²,

Kawaguchi³

et al. 2023

Evidence-Based Complementary and Alternative Medicine

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“…Oral administration of royal jelly induced the elevation of tail blood flow and vasorelaxation in the isolated aorta and superior mesenteric arteries of rats. Furthermore, the vasorelaxation was canceled by N G -nitro-L-arginine methyl ester (a nitric oxide synthase inhibitor) and atropine (a muscarinic receptor antagonist), indicating that royal jelly acts via muscarinic receptor agonism and nitric oxide (NO) production from the vascular endothelium 30) . Moreover, we speculate that another possible mechanism of the vasorelaxation effects of royal jelly is through insulin signaling.…”

Section: Discussionmentioning

confidence: 99%

A Randomized, Double-Blind Comparison Study of Royal Jelly to Augment Vascular Endothelial Function in Healthy Volunteers

Fujisue

Yamamoto

Sueta

et al. 2022

JAT

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Royal jelly, a creamy substance secreted by honeybees, has been reported to have beneficial effects against dyslipidemia and metabolic syndrome. However, the effects of royal jelly on atherogenesis remain unknown. Hence, we prospectively evaluated whether royal jelly augments vascular endothelial function, which can reflect early atherogenesis, in healthy volunteers. Methods:This was a single-center, double-blind, 1:1 randomized placebo-controlled study conducted from October 2018 to December 2019. A total of 100 healthy volunteers were randomly assigned to receive either royal jelly 690 mg or placebo daily for 4 weeks. The primary endpoint was augmentation in vascular endothelial function as assessed using the change in the reactive hyperemia peripheral arterial tonometry index (RH-PAT) index, and the secondary endpoints were the changes in liver function and lipid profiles between baseline and 4 weeks after enrollment. Results:The mean age of the participants was 35.0±9.3 years in the placebo group and 36.1±9.1 years in the royal jelly groups; 45% and 50% of the placebo and the royal jelly groups, respectively, were male. The percentage relative change in the RH-PAT index was significantly higher in the royal jelly group than in the placebo group (21.4%±53.1% vs. 0.05%±40.9%, P=0.037). The percentage relative changes in alanine aminotransferase and γ-glutamyl transpeptidase were significantly lower in the royal jelly group than in the placebo group (alanine aminotransferase: −6.06%±22.2% vs. 11.6%±46.5%, P = 0.02; γ-glutamyl transpeptidase: −3.45%±17.8% vs. 4.62%±19.4%, P = 0.045). Lipid profiles were not significantly different between the two groups. Conclusions: Royal jelly might have antiatherogenic property by improving vascular endothelial function. It also augmented liver functions in healthy volunteers.its risk factors, such as diabetes mellitus, hypertension, and dyslipidemia, are often already advanced at the onset of ASCVD, primary prevention is key to mitigating the occurrence of atherosclerosis-related cardiovascular events and death.

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“…It is reported that RJ contains acetylcholine [ 38 ]. Recently, RJ was shown to induce vasorelaxation through an acetylcholine-dependent mechanism in vivo [ 39 ]. These results suggested that RJ directly affect NMJ in an acetylcholine-dependent manner.…”

Section: Discussionmentioning

confidence: 99%

Royal Jelly Delays Motor Functional Impairment During Aging in Genetically Heterogeneous Male Mice

Okumura¹,

Toda

Ozawa

et al. 2018

Nutrients

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Aging is associated with motor disorders that decrease the quality of life (QOL). Royal jelly (RJ), used as a dietary supplement, has shown various health benefits and, therefore, it has the potential to improve the QOL during aging. We have previously developed protease enzyme-treated RJ to avoid the anaphylactic response induced by RJ supplementation. However, the effects of a lifelong treatment with RJ on normal aging have not been fully clarified. In this study, we investigated the effects of enzyme-untreated RJ (NRJ) and enzyme-treated RJ (ERJ) on the aging process focusing on motor functions, by using a genetically heterogeneous (HET) mouse model experimentally endowed with genetic diversity. We performed four different physical performance tests (grip strength, wire hang, horizontal bar, and rotarod). We showed that the age-related impairment of the motor functions was significantly delayed in RJ-treated mice. Both NRJ and ERJ were similarly effective against these types of aging-associated declines. Histological analyses revealed that the RJ treatment affected the muscle fiber size at an advanced age. We also demonstrated that age-related changes in muscle satellite cell markers and catabolic genes were affected in RJ-treated mice. These results suggest that non-protein components of RJ improved the motor function in aging mice. These findings indicate that RJ has the potential to change the QOL during aging by regulating the motor function.

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Royal jelly increases peripheral circulation by inducing vasorelaxation through nitric oxide production under healthy conditions

Cited by 12 publications

References 30 publications

Royal Jelly Increases Hematopoietic Stem Cells in Peripheral Blood: A Double‐Blind, Placebo‐Controlled, Randomized Trial in Healthy Subjects

Royal Jelly Increases Hematopoietic Stem Cells in Peripheral Blood: A Double‐Blind, Placebo‐Controlled, Randomized Trial in Healthy Subjects

A Randomized, Double-Blind Comparison Study of Royal Jelly to Augment Vascular Endothelial Function in Healthy Volunteers

Royal Jelly Delays Motor Functional Impairment During Aging in Genetically Heterogeneous Male Mice

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